The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk. Epidemiological and biomarker data from a UK prospective cohort study (EPIC-Norfolk).

Abstract:

OBJECTIVE:The development of gallstones is influenced by obesity and alcohol. This study aimed to precisely quantify these risks and investigate whether the aetiological mechanism may involve serum lipids, for the first time using a European prospective cohort study. METHODS:The European Prospective Investigation into Cancer-Norfolk, recruited 25 639 men and women, aged 40 to 74 years, between 1993 and 1997. At enrolment weight, height and alcohol intake were recorded and nonfasting blood samples taken to measure serum triglycerides, cholesterol, high-density lipoproteins and low-density lipoproteins. The cohort was monitored for 14 years for symptomatic gallstones. Cox regression estimated sex-specific hazard ratios (HRs) for symptomatic gallstones adjusted for covariates. RESULTS:Symptomatic gallstones developed in 296 people (67.9% women). For each additional unit of BMI, the HR in men was 1.08 [95% confidence interval (CI)=1.02-1.14]; in women the HR was 1.08 (95% CI=1.06-1.11). Every unit of alcohol consumed per week decreased risk in men by 3% (HR=0.97, 95% CI=0.95-0.99) with no effect in women. Serum triglycerides increased risk in men (highest vs. lowest quarter HR=2.02, 95% CI=1.03-3.98) and women (HR=2.43, 95% CI=1.52-3.90). Increased high-density lipoprotein was associated with a decreased risk in men (highest vs. lowest quarter HR=0.22, 95% CI=0.09-0.52) and women (HR=0.55, 95% CI=0.36-0.85). No effects were found for serum cholesterol and low-density lipoprotein. CONCLUSION:Obesity and alcohol influence gallstone formation, possibly in part through their effects on serum lipids. Reducing obesity may prevent gallstones in the population, as 38% of incident cases of gallstones were associated with a BMI of more than 25.

authors

Banim PJ,Luben RN,Bulluck H,Sharp SJ,Wareham NJ,Khaw KT,Hart AR

doi

10.1097/MEG.0b013e3283477cc9

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

733-40

issue

8

eissn

0954-691X

issn

1473-5687

journal_volume

23

pub_type

杂志文章,多中心研究
  • Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhoea due to Helicobacterpylori eradication.

    abstract:BACKGROUND AND AIM:Antibiotic-associated diarrhoea may develop during or following Helicobacter pylori eradication. We aimed to evaluate the efficacy and safety of Saccharomyces boulardii in preventing antibiotic-associated diarrhoea in patients receiving antibiotics for H. pylori eradication. METHODS:In a multicentre...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/00042737-200512000-00015

    authors: Duman DG,Bor S,Ozütemiz O,Sahin T,Oğuz D,Iştan F,Vural T,Sandkci M,Işksal F,Simşek I,Soytürk M,Arslan S,Sivri B,Soykan I,Temizkan A,Beşşk F,Kaymakoğlu S,Kalayc C

    更新日期:2005-12-01 00:00:00

  • The Glasgow Dyspepsia Severity Score--a tool for the global measurement of dyspepsia.

    abstract:OBJECTIVE:There is currently no reliable tool for providing a global measurement of the severity of dyspepsia in patients with a variety of upper gastrointestinal disorders. We have designed a questionnaire which records frequency of symptoms, effect on routine activities, time off work, frequency of medical consultati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199610000-00006

    authors: el-Omar EM,Banerjee S,Wirz A,McColl KE

    更新日期:1996-10-01 00:00:00

  • Acute inflammatory intestinal vascular lesions and in situ abnormalities of the plasminogen activation system in Crohn's disease.

    abstract:OBJECTIVES:The distribution of the intestinal vascular lesions and their relation with the fibrinolysis process are poorly known in Crohn's disease (CD). The mediators of the plasminogen activator system, namely urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA) and plasminogen activa...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199910000-00007

    authors: Desreumaux P,Huet G,Zerimech F,Gambiez L,Balduyck M,Baron P,Degand P,Cortot A,Colombel JF,Janin A

    更新日期:1999-10-01 00:00:00

  • Aspartate aminotransferase to platelet ratio index for fibrosis evaluation in chronic viral hepatitis.

    abstract:OBJECTIVE:We assessed the value of the recently developed aspartate aminotransferase to platelet ratio index (APRI) for predicting significant fibrosis or cirrhosis in patients with chronic hepatitis C or HBeAg-negative chronic hepatitis B. METHODS:In total, 489 patients (chronic hepatitis C, 284 patients; HBeAg-negat...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200604000-00012

    authors: Chrysanthos NV,Papatheodoridis GV,Savvas S,Kafiri G,Petraki K,Manesis EK,Archimandritis AJ

    更新日期:2006-04-01 00:00:00

  • Gastric adenocarcinoma with leptomeningeal carcinomatosis as the presenting manifestation: an autopsy case report.

    abstract::Leptomeningeal carcinomatosis is a clinically important and severe complication in patients with cancer. Leptomeningeal involvement as a secondary event in gastric carcinoma is rarely reported and usually occurs late in advanced disease. Herein, we report a case of leptomeningeal carcinomatosis as the initial manifest...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200505000-00016

    authors: Braeuninger S,Mawrin C,Malfertheiner P,Schildhaus HU,Seiler C,Dietzmann K,Lins H

    更新日期:2005-05-01 00:00:00

  • Two cases of inverted hyperplastic polyps of the colon and association with adenoma.

    abstract::Here we report two cases of inverted hyperplastic polyps of the colon. The first patient showed three inverted hyperplastic polyps in the ascending colon, one of which was associated with adenoma. We immunostained this adenoma-associated polyp using anti-beta-catenin antibody and found accumulation of beta-catenin in ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200401000-00016

    authors: Kuribayashi K,Ishii T,Ishidate T,Ban N,Hirata Y,Hashida H,Saito K,Iwashiro N,Ohara M,Ishizaka M,Azumad M,Hayashi T,Takayama T

    更新日期:2004-01-01 00:00:00

  • Colonic endocrine cells in patients with carcinoma of the colon.

    abstract:OBJECTIVE:To investigate the colonic endocrine cells in patients with colon carcinoma in order to establish a possible abnormality. PATIENTS:Twelve patients with colon adenocarcinoma (eight women and four men; mean age 69 years; range 52-88 years) were studied. As controls, macroscopically and histologically normal ti...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199806000-00015

    authors: El-Salhy M,Mahdavi J,Norrgård O

    更新日期:1998-06-01 00:00:00

  • Retrieval and re-evaluation of previously diagnosed chronic hepatitis C infections lost to medical follow-up in the Netherlands.

    abstract:OBJECTIVES:Many individuals previously diagnosed with chronic hepatitis C virus (HCV) infection are likely to be lost to medical follow-up and, therefore, remain untreated despite new highly effective drug treatment, direct acting antivirals. We aim to identify and retrieve these chronic HCV-infected individuals to re-...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001593

    authors: Heil J,Soufidi K,Stals F,Frantzen H,Robroek-Schaecken A,Bakker CM,van Nunen AB,Dukers-Muijrers NHTM,Hoebe CJPA

    更新日期:2020-07-01 00:00:00

  • Serum anti-Lewis X antibody is associated with VacA seropositivity but not atrophic gastritis in patients with Helicobacter pylori infection.

    abstract:OBJECTIVES:Lipopolysaccharides of Helicobacter pylori have an antigenic structure that mimics Lewis X occurring in gastric mucosa. The pathogenic role of antigenic mimicry in H. pylori-induced gastritis has been of recent interest. The aim of this study was to examine the relevance of anti-Lewis X antibody in the devel...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200103000-00002

    authors: Shimoyama T,Fukuda S,Tanaka M,Sugawara N,Kurimoto F,Munakata A

    更新日期:2001-03-01 00:00:00

  • Individualized surveillance of chronic hepatitis B patients according to hepatocellular carcinoma risk based on PAGE-B scores.

    abstract:BACKGROUND AND AIMS:Current guidelines for chronic hepatitis B (CHB) patients are to undergo surveillance for hepatocellular carcinoma (HCC) with 6-month ultrasonography. We aimed to compare detection rates of very-early-stage HCC in two groups: group A, undergoing 6-month ultrasonography versus group B, undergoing 6-m...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001870

    authors: Kim JH,Kang SH,Lee M,Choi HS,Jun BG,Kim TS,Choi DH,Suk KT,Kim MY,Kim YD,Cheon GJ,Baik SK,Kim DJ

    更新日期:2020-08-14 00:00:00

  • Gallstones in childhood: etiology, clinical features, and prognosis.

    abstract:AIM:The aim of this study was to determine demographic and clinical features in children diagnosed with gallstones, risk factors for gallstone formation, the effectiveness of ursodeoxycholic acid therapy, and the course of the disease. MATERIALS AND METHODS:Patients aged 0-18 years were followed up for at least 6 mont...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000726

    authors: Serdaroglu F,Koca YS,Saltik F,Koca T,Dereci S,Akcam M,Akcam FZ

    更新日期:2016-12-01 00:00:00

  • Serological markers of autoimmunity in children with hepatitis A: relation to acute and fulminant presentation.

    abstract:OBJECTIVES:Hepatitis A virus (HAV) infection tends to be a self-limiting disease without serious sequelae, but fulminant hepatitis, with a high mortality, develops in 0.1-0.2% of the cases. Sometimes, HAV infection precipitates autoimmune hepatitis (AIH). We aimed to assess the frequency and clinical significance of se...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000413

    authors: Abdel-Ghaffar TY,Sira MM,Sira AM,Salem TA,El-Sharawy AA,El Naghi S

    更新日期:2015-10-01 00:00:00

  • Validity of N-terminal propeptide of the brain natriuretic peptide in predicting left ventricular diastolic dysfunction diagnosed by tissue Doppler imaging in patients with chronic liver disease.

    abstract:BACKGROUND AND AIMS:Left ventricular diastolic dysfunction has been reported in patients with liver cirrhosis. Although conventional Doppler echocardiography has been used to assess diastolic filling dynamics, this technique is limited in diagnosing left ventricular diastolic dysfunction. The aim of the study was to va...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282fb7cd0

    authors: Raedle-Hurst TM,Welsch C,Forestier N,Kronenberger B,Hess G,Herrmann E,Zeuzem S,Raedle J

    更新日期:2008-09-01 00:00:00

  • Trimodal imaging endoscopy reduces the risk of synchronous gastric neoplasia.

    abstract:BACKGROUND AND AIM:The accurate detection of synchronous neoplasia is important to reduce the risk of recurrence after endoscopic resection. Trimodal imaging endoscopy (TMIE) was developed for this purpose. Our aim was to compare the effects of TMIE and white-light imaging endoscopy (WLIE) in gastric neoplasia detectio...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000278

    authors: Gweon TG,Park JM,Lim CH,Kim JS,Cho YK,Kim SW,Choi MG

    更新日期:2015-03-01 00:00:00

  • Acute pancreatitis in peritoneal dialysis: a case report with literature review.

    abstract::Abdominal pain with a discoloured dialysate in a patient on peritoneal dialysis (PD) is usually attributed to infective peritonitis. Although acute pancreatitis (AP) is not usually a complication of end-stage renal disease, some studies suggest an increased risk especially in patients on PD. We report a case of idiopa...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0b013e32834d4bcc

    authors: Manga F,Lim CS,Mangena L,Guest M

    更新日期:2012-01-01 00:00:00

  • Pathophysiology of duodenal ulcer disease.

    abstract::Before the discovery of Helicobacter pylori infection some 12 years ago, three major disturbances in gastric physiology had been identified in patients with duodenal ulcer disease. These abnormalities were: impaired acid inhibition of gastrin release from the antral mucosa, increased basal and stimulated acid secretio...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: McColl KE

    更新日期:1997-04-01 00:00:00

  • Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents.

    abstract:OBJECTIVE:To compare the effects of aerobic training (AT) with aerobic plus resistance training (AT+RT) in nonalcoholic fatty liver disease (NAFLD) obese adolescents. DESIGN:Long-term interdisciplinary weight-loss therapy (1 year of clinical, nutritional, psychological, and exercise-related intervention). PARTICIPANT...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0b013e32835793ac

    authors: de Piano A,de Mello MT,Sanches Pde L,da Silva PL,Campos RM,Carnier J,Corgosinho F,Foschini D,Masquio DL,Tock L,Oyama LM,do Nascimento CM,Tufik S,Dâmaso AR

    更新日期:2012-11-01 00:00:00

  • Transjugular intrahepatic portosystemic stent-shunt (TIPSS) insertion as a prelude to orthotopic liver transplantation in patients with severe portal hypertension.

    abstract:OBJECTIVE:To investigate the impact of preoperative transjugular intrahepatic portosystemic stent-shunt (TIPSS) on patients undergoing liver transplantation. DESIGN:A retrospective non-randomized comparative clinical study. SETTING:Tertiary referral institution. PATIENTS, PARTICIPANTS:Twenty-four patients with liver...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199612000-00002

    authors: John TG,Jalan R,Stanley AJ,Redhead DN,Sanfey HA,Hayes PC,Garden OJ

    更新日期:1996-12-01 00:00:00

  • Subclinical spontaneous bacterial peritonitis at the time of liver transplantation does not impact on outcomes.

    abstract:OBJECTIVES:Liver transplant recipients are often screened for spontaneous bacterial peritonitis during the immediate preoperative evaluation to determine medical fitness to proceed. However, it is unknown whether subclinical spontaneous bacterial peritonitis impacts on post-transplant outcomes. Our aim was to determine...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000473

    authors: McDonald DP,Leithead JA,Gunson BK,Ferguson JW

    更新日期:2016-01-01 00:00:00

  • High frequency of gastric cancer precursor lesions in patients with gastric xanthelasma: a prospective case-control study.

    abstract:OBJECTIVE:An association of gastric cancer and precursor lesions with gastric xanthelasma has frequently been reported. However, the incidence of both gastric xanthelasma and gastric cancer precursor lesions increases with age. The aim of this study was to evaluate the frequency and characteristics of atrophic gastriti...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001795

    authors: Sayar S,Ayranci G,Kürbüz K,Ak Ç,Tarikçi Kiliç E,Kahraman R,Atalay R,Öztürk O,Çalişkan Z,Adali G,Doganay L,Özdil K

    更新日期:2020-09-01 00:00:00

  • A new organotypic model to study cell interactions in the intestinal mucosa.

    abstract:BACKGROUND:Recently, we demonstrated that freshly elutriated monocytes differentiate into macrophages with a phenotype similar to that of intestinal macrophages in a three-dimensional model of intestinal epithelial cells. Here we describe a more organotypic model to study cell interactions in the intestinal mucosa. ME...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200608000-00017

    authors: Spottl T,Hausmann M,Gunckel M,Herfarth H,Herlyn M,Schoelmerich J,Rogler G

    更新日期:2006-08-01 00:00:00

  • High incidence of fermentation in the digestive tract in patients with reflux oesophagitis.

    abstract:OBJECTIVES:Because bacteria represent the sole source of gut hydrogen (H2) and methane (CH4), fasting breath H2 and CH4 gases have been used as markers of colonic fermentation. The presence of carbohydrates in the colonic lumen inhibits gastric and pancreatic secretions, and also influences lower oesophageal sphincter ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200605000-00013

    authors: Urita Y,Sugimoto M,Hike K,Torii N,Kikuchi Y,Kurakata H,Kanda E,Sasajima M,Miki K

    更新日期:2006-05-01 00:00:00

  • Association of gastric disease with polymorphisms in the inflammatory-related genes IL-1B, IL-1RN, IL-10, TNF and TLR4.

    abstract:OBJECTIVES:This study aimed to investigate if single nucleotide polymorphisms (SNPs) in a series of inflammatory genes were associated with the development of the most common pathologies thought to precede gastric cancer development namely; Helicobacter pylori (H. pylori)-associated gastritis and intestinal metaplasia....

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283140eea

    authors: Murphy G,Thornton J,McManus R,Swan N,Ryan B,Hughes DJ,O'Morain CA,O'Sullivan M

    更新日期:2009-06-01 00:00:00

  • Enteral nutrition.

    abstract::This review summarizes research studies published in recent years that are useful for clinicians considering the enteral route as a means of nutritional support for their patients. In this period, there has been a move away from emphasis on what nutrients are given to a more considered appraisal of how nutrients are p...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Payne-James JJ

    更新日期:1995-06-01 00:00:00

  • Improving diagnostic yield in obscure gastrointestinal bleeding--how virtual chromoendoscopy may be the answer.

    abstract:BACKGROUND AND AIM:A significant proportion of patients presenting with obscure gastrointestinal bleeding (OGIB) have negative small bowel capsule endoscopy (SBCE) examinations, and yet remain at risk of rebleeding. We aimed to evaluate whether a second-look review of SBCE images using flexible spectral color enhanceme...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000358

    authors: Dias de Castro F,Magalhães J,Boal Carvalho P,Cúrdia Gonçalves T,Rosa B,Moreira MJ,Cotter J

    更新日期:2015-06-01 00:00:00

  • Intracellular cytokine expression in peritoneal monocyte/macrophages obtained from patients with cirrhosis and presence of bacterial DNA.

    abstract:BACKGROUND:The detection of bacterial DNA in serum and ascitic fluid from patients with cirrhosis and ascites is interpreted as molecular evidence of intestinal bacterial translocation and considered sufficient to activate the cellular immune response. In vitro studies on ascitic fluid culture have shown a close relati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200501000-00010

    authors: Francés R,Rodríguez E,Muñoz C,Zapater P,De la ML,Ndongo M,Pérez-Mateo M,Such J

    更新日期:2005-01-01 00:00:00

  • Prevalence and indicators of use of complementary and alternative medicine in Austrian patients with inflammatory bowel disease.

    abstract:OBJECTIVE:Complementary and alternative medicine (CAM) seems to be frequently used among patients with inflammatory bowel disease (IBD). We aimed to determine the prevalence and indicators of CAM use in Austrian IBD patients. METHODS:In a multicentre cross-sectional study, adult patients with IBD attending 18 Austrian...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001533

    authors: Gröchenig HP,Waldhör T,Haas T,Wenzl H,Steiner P,Koch R,Feichtenschlager T,Eckhardt G,Mayer A,Kirchgatterer A,Ludwiczek O,Platzer R,Papay P,Gartner J,Fuchssteiner H,Miehsler W,Peters PG,Reicht G,Kutschera M,Dejaco C

    更新日期:2019-10-01 00:00:00

  • Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease.

    abstract:OBJECTIVE:Recent studies have suggested that endotoxin-induced cytokines play an important role in nonalcoholic fatty liver disease (NAFLD). Rifaximin is a nonabsorbable antibiotic that might act on Gram-negative bacteria, thereby inhibiting endotoxin proinflammatory cytokine production in patients with NAFLD. Our aim ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000348

    authors: Gangarapu V,Ince AT,Baysal B,Kayar Y,Kılıç U,Gök Ö,Uysal Ö,Şenturk H

    更新日期:2015-07-01 00:00:00

  • Report of a collaborative trial to investigate the performance of the R5 enzyme linked immunoassay to determine gliadin in gluten-free food.

    abstract:OBJECTIVE:Analytical methods for measurements of gluten in the low level range of 20-200 ppm of gluten, as required for gluten-free food, have never been endorsed by the Codex Alimentarius. With the aim of investigating standardized and reliable methods for the detection of gliadin in food with detection limits lower t...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00042737-200510000-00008

    authors: Méndez E,Vela C,Immer U,Janssen FW

    更新日期:2005-10-01 00:00:00

  • Infliximab in refractory coeliac disease.

    abstract::Coeliac disease is generally well controlled with gluten-free diet but a small proportion of patients require corticosteroids or immunomodulatory agents. Response to anti-tumour necrosis factor (anti-TNF) agents raises interesting questions about both the pathogenesis of coeliac disease and the mechanism of action of ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200506000-00002

    authors: Chaudhary R,Ghosh S

    更新日期:2005-06-01 00:00:00