Parenteral nutrition in preterm neonates with and without carnitine supplementation.

Abstract:

:The effects of carnitine supplementation on fat and glucose metabolism and carnitine balance were studied in 12 preterm neonates receiving full or partial parenteral nutrition (PN) for 5 to 21 days. The gestational age ranged from 27 to 32 weeks and the birth weight from 790 to 2090 g. The neonates were assigned at random to receive either L-carnitine 10 mg/kg (n = 6) or saline (n = 6). In the carnitine group, increased concentrations in plasma of total and free carnitine were observed. Less than 50% of the given dose was recovered in urine. In the placebo group no changes in the total plasma carnitine concentration were seen. In all neonates plasma triglycerides, free fatty acids, glycerol, alanine, 3-hydroxybutyrate (BOB), glucose and lactate were measured at predetermined intervals. The only significant difference between the groups was higher BOB-concentrations in the carnitine group 2 days after the start of parenteral nutrition. Elevated BOB concentrations are an indicator of improved fatty acid oxidation in the carnitine group. In this study, only a temporary effect of the carnitine supplementation was found.

authors

Larsson LE,Olegård R,Ljung BM,Niklasson A,Rubensson A,Cederblad G

doi

10.1111/j.1399-6576.1990.tb03132.x

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

501-5

issue

6

eissn

0001-5172

issn

1399-6576

journal_volume

34

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章

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    pub_type: 杂志文章,随机对照试验

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