Abstract:
PURPOSE:To evaluate changes in blood pressure during adrenal radiofrequency ablation (RFA) and analyze histopathologic outcomes in swine adrenal glands. MATERIALS AND METHODS:Animal Care Committee approval was obtained for this study. After laparotomy, a single adrenal gland was ablated from each of six animals (six RF sessions total). An internally cooled-tip RF electrode was placed along the long axis of the adrenal gland, and RF energy was applied for 10 min in each adrenal gland. Blood pressure and heart rate were monitored, and serum epinephrine, norepinephrine, and cortisol levels were measured before, during, and after RFA. Histological study was performed using hematoxylin-eosin staining. RESULTS:RFA was completed according to a planned protocol in all adrenal glands. Blood pressure increased to >200 mm Hg after an increase in heart rate during all six RF sessions. Mean serum epinephrine and norepinephrine levels increased significantly during RFA. However, mean cortisol levels showed no significant increase during or after RFA. Histological studies showed adrenal cell necrosis throughout the adrenal glands in all but one pig, with the mean necrosis rate being 99.1 ± 2.3% (range 94.3-100%). CONCLUSION:Adrenal RFA causes extensive adrenal cell damage and causes catecholamine-induced hypertension.
journal_name
Cardiovasc Intervent Radioljournal_title
Cardiovascular and interventional radiologyauthors
Yamakado K,Takaki H,Uchida K,Nakatsuka A,Shiraishi T,Takeda Kdoi
10.1007/s00270-010-0078-6subject
Has Abstractpub_date
2011-08-01 00:00:00pages
839-44issue
4eissn
0174-1551issn
1432-086Xjournal_volume
34pub_type
杂志文章abstract::Congenital anomalies of the inferior vena cava (IVC) are increasingly recognized with CT and venography techniques. Although many patients with IVC anomalies are asymptomatic, recent studies have suggested an association with venous thromboembolism. We report the case of a 62-year-old woman with extensive venous clot ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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abstract::A prototype directional atherectomy catheter (Omnicath) was evaluated in four Yucatan microswines. Atherectomy was performed on iliac or aortic target lesions. After control angiography, the animals were sacrificed and the target arteries were examined histologically. Atherectomy resulted in arterial ruptures in three...
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journal_title:Cardiovascular and interventional radiology
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更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00270-013-0577-3
更新日期:2013-12-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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doi:
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journal_title:Cardiovascular and interventional radiology
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更新日期:2008-01-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
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更新日期:2017-05-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 临床试验,杂志文章
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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更新日期:2019-04-01 00:00:00
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