Complement activation by surface modified poly(methyl methacrylate) intraocular lenses.

Abstract:

:The complement activation potential of surface modified (passivated) poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) with polypropylene loops was compared to that of standard PMMA IOLs with polypropylene loops. Both lens types were incubated in human sera for six hours and then the C3a and C5a levels were measured by radioimmunoassay. Sera incubated with either IOL type generated significantly higher levels of C3a and C5a than control sera incubated without any IOL. The amount of C3a and C5a generated by the passivated PMMA IOLs was comparable to the levels generated by the standard PMMA IOLs. The results of this study show that surface passivated PMMA IOLs with polypropylene loops activated complement to the same level as standard PMMA IOLs with polypropylene loops.

authors

Kochounian HH,Maxwell WA,Gupta A

doi

10.1016/s0886-3350(13)80243-x

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

139-42

issue

2

eissn

0886-3350

issn

1873-4502

pii

S0886-3350(13)80243-X

journal_volume

17

pub_type

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