Abstract：
AIMS AND OBJECTIVES:To review the use of second-line tyrosine kinase inhibitors in patients with chronic myeloid leukaemia (CML) and provide recommendations for managing adverse events (AEs) to maximise patient benefit. BACKGROUND:Treatment of CML has been revolutionised with the advent of tyrosine kinase inhibitors (TKIs) that target the breakpoint cluster region-Abelson (BCR-ABL) kinase. Imatinib is the only first-line TKI currently available for the treatment of CML; however, intolerance and resistance remain significant clinical challenges. The approved second-line treatment options for CML are dasatinib, nilotinib or escalated-dose imatinib. DESIGN:Review article. METHODS:Searches of PubMed, ASCO and ASH electronic databases for relevant search terms were performed between July 2008-January 2009. FINDINGS:Dasatinib has no cross-intolerance with imatinib, and the most frequent AEs (cytopenias and pleural and pericardial effusions) can generally be managed by dose interruption and reduction. Nilotinib has a high degree of haematologic cross-intolerance with first-line imatinib. As might be expected, high-dose imatinib has the potential for more severe AEs than standard-dose imatinib. CONCLUSIONS:There are known safety issues inherent to each TKI and close monitoring by nursing staff is necessary to identify and effectively manage AEs. RELEVANCE TO CLINICAL PRACTICE:All three TKIs have demonstrated potential for fluid retention and cardiotoxicity. Nurses should be aware of how these AEs manifest and intervene appropriately. The safety profiles of these TKIs clearly differs and it is important to consider factors such as comorbidities when making treatment decisions.
journal_name
J Clin Nursjournal_title
Journal of clinical nursingauthors
Tinsley SMdoi
10.1111/j.1365-2702.2009.03167.xsubject
Has Abstractpub_date
2010-05-01 00:00:00pages
1207-18issue
9-10eissn
0962-1067issn
1365-2702pii
JCN3167journal_volume
19pub_type
杂志文章,评审abstract：AIMS AND OBJECTIVES:We aimed to synthesise evidence from published literature on non-invasive ventilation to inform nurses involved in the clinical management of non-invasive ventilation in the emergency department. BACKGROUND:Non-invasive ventilation is a form of ventilatory support that does not require endotracheal...
journal_title：Journal of clinical nursing
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2702.2008.02766.x
更新日期：2009-12-01 00:00:00
abstract：AIMS AND OBJECTIVES:To analyse the impact of preoperative defecation pattern on postoperative defecation pattern for patients undergoing cardiac surgery. BACKGROUND:Constipation is a neglected problem that occurs frequently after cardiac surgery. DESIGN:Descriptive study. METHOD:The study sample comprised 102 patien...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.13473
更新日期：2017-02-01 00:00:00
abstract：AIM AND OBJECTIVES:To validate the Numeric Rating Scale (NRS) for postoperative nausea assessments, and determine whether a central tendency, median, based on patients' self-rated nausea is a clinically applicable daily measure to describe patients' nausea after major surgery. BACKGROUND:Postoperative nausea causes ma...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.14705
更新日期：2019-03-01 00:00:00
abstract：AIMS AND OBJECTIVES:The purpose of this study was to evaluate the effectiveness of a self-medication programme (SMP) for inpatients of the Nursing Convalescent Unit, a 26-bed unit with medical and surgical patients. BACKGROUND:Self-medication is an important part of self-management of chronic illness. Self-medication ...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/j.1365-2702.2006.01398.x
更新日期：2006-08-01 00:00:00
abstract：AIMS AND OBJECTIVES:Day surgery shifts the responsibility of care from the hospital to patients and their families. This study explored how partners of day surgery patients experienced their role after patient discharge. BACKGROUND:Many surgical procedures formerly requiring inpatient care are now carried out on a day...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/j.1365-2702.2012.04116.x
更新日期：2012-09-01 00:00:00
abstract：AIMS AND OBJECTIVES:This study develops a new instrument, the Spiritual Care Intervention-Provision Scale, and assesses its psychometric properties in an Arab Muslim nurse sample. The Spiritual Care Intervention-Provision Scale was developed to measure the frequency with which nurses provided aspects of spiritual care....
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.13174
更新日期：2016-08-01 00:00:00
abstract：:It has been well documented that newly qualified nurses require support in developing confidence and professional competence. Although preceptorship models have gone some way in addressing this need, innovative and flexible models of facilitation and development are also required to respond to local demands. In the pr...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1046/j.1365-2702.2002.00568.x
更新日期：2002-01-01 00:00:00
abstract：AIM:To understand student nurse-patient interaction better and to assess the effectiveness of a teaching and learning resource consisting of tapes and transcriptions of actual nurse-patient interaction. DESIGN:Applied conversation analysis and analysis of semi-structured lecture evaluation forms. BACKGROUND:Little re...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/j.1365-2702.2007.01948.x
更新日期：2007-12-01 00:00:00
abstract：AIMS AND OBJECTIVES:To describe the cues and factors that nurses use in their decision-making when responding to clinical alarms. BACKGROUND:Alarms are designed to be very sensitive, and as a result, they are not very specific. Lack of adherence to the practice standards for electrocardiographic monitoring in hospital...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.12625
更新日期：2015-01-01 00:00:00
abstract：AIM:To examine the prescribing practices of supplementary nurse prescribers (working in both primary and secondary care) who prescribe medicines for patients with skin conditions and the factors that facilitate or inhibit this mode of prescribing. BACKGROUND:Nurses work in a variety of roles, with varying levels of ex...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/j.1365-2702.2007.01641.x
更新日期：2007-07-01 00:00:00
abstract：AIMS AND OBJECTIVES:This review aims to answer the question 'What are the possible effects on children of having a parent with chronic renal failure?' BACKGROUND:Chronic illness affects the whole family, not just the individual with the illness. It would appear that little research has been undertaken to consider the ...
journal_title：Journal of clinical nursing
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2702.2007.02154.x
更新日期：2008-03-01 00:00:00
abstract：AIM:This paper described a case study of a randomised controlled trial with the aim to illuminate how the intervention described takes into account the important methodological considerations for enhancing the efficacy of psychoeducational interventions for paediatric patients. BACKGROUND:Many nursing intervention stu...
journal_title：Journal of clinical nursing
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-2702.2009.02913.x
更新日期：2009-11-01 00:00:00
abstract：:This paper presents a proposed model: The Attending Nursing Caring Model (ANCM) as an exemplar for advancing and transforming nursing practice within a reflective, theoretical and evidence-based context. Watson's theory of human caring is used as a guide for integrating theory, evidence and advanced therapeutics in th...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1046/j.1365-2702.2003.00774.x
更新日期：2003-05-01 00:00:00
abstract：AIM AND OBJECTIVE:The purpose of this study was to evaluate patients' knowledge regarding their medication regime following a nursing interventional project in patient medication education. DESIGN:Evaluation. BACKGROUND:Educating patients during their hospital stay regarding their medical treatment is an issue which ...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/j.1365-2702.2009.02844.x
更新日期：2009-09-01 00:00:00
abstract：AIM:The aim of this study was to explore how the planning, daily care and follow-up procedures work in the care trajectory for patients treated with home enteral tube feeding, from the perspective of hospital and community care nurses. BACKGROUND:Discharge planning for patients in need of home enteral tube feeding is ...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/j.1365-2702.2007.02181.x
更新日期：2008-11-01 00:00:00
abstract：AIMS AND OBJECTIVES:This study examined practices of health care providers who thicken oral fluids for patients with impaired swallowing (dysphagia). It contrasts viscosity (thickness) of nectar-like and honey-thick consistencies prepared and measured in a laboratory setting to actual practices in health care settings ...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/j.1365-2702.2009.03009.x
更新日期：2010-06-01 00:00:00
abstract：AIMS AND OBJECTIVES:To evaluate the effect of sociodemographic and clinical factors on body image, sexual function and sexual satisfaction in women following breast cancer treatment. BACKGROUND:Women with breast cancer may experience a wide range of symptoms associated with body image and sexuality that can severely a...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.13125
更新日期：2016-06-01 00:00:00
abstract：AIMS AND OBJECTIVES:This study explored the fatigue experiences in older Taiwanese women with breast cancer. BACKGROUND:Cancer is a common disease for older people, and breast cancer ranks second in occurrence among all cancers. Fatigue is the most frequently seen symptom, with more than 90% of cancer patients having ...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/j.1365-2702.2009.03064.x
更新日期：2010-03-01 00:00:00
abstract：AIMS AND OBJECTIVES:To describe fear, the threats causing fear and the occurrence of fear among emergency department nursing staff and physicians. BACKGROUND:The emergency department is a challenging workplace where the staff is often confronted by factors that cause fear. DESIGN:A cross-sectional study. METHODS:A s...
journal_title：Journal of clinical nursing
pub_type： 杂志文章,多中心研究
doi：10.1111/jocn.13633
更新日期：2017-10-01 00:00:00
abstract：AIMS AND OBJECTIVES:To explore parents' experiences with paediatric fever to understand their needs for information and support. BACKGROUND:Paediatric fever is a normal part of childhood, and multiple episodes of fever are a common occurrence between infancy and adulthood. Despite this expectation, paediatric fever of...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.15165
更新日期：2020-03-01 00:00:00
abstract：AIMS AND OBJECTIVES:To evaluate the impact of a nurse practitioner-led phase two cardiac rehabilitation and secondary prevention programme on attendance and compliance. BACKGROUND:Despite strong evidence for the benefits of cardiac rehabilitation, attendance/completion rates remain low. Nurse practitioner-led services...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.15133
更新日期：2020-03-01 00:00:00
abstract：AIM AND OBJECTIVES:To explore the experience of pulmonary exacerbation from the perspective of adults with cystic fibrosis. BACKGROUND:While management of pulmonary exacerbations is a pillar of cystic fibrosis care, little is known of patients' perspectives. Understanding the patient's experience is essential for deve...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.14646
更新日期：2019-01-01 00:00:00
abstract：AIMS:The purpose of this study was to identify the incidence rate of eye disorders and further to identify factors related to incidence of eye disorders in intensive care unit patients. BACKGROUND:Although the incidence of eye disorders in intensive care unit patients is very high, it is difficult to come to an accura...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/j.1365-2702.2008.02388.x
更新日期：2009-01-01 00:00:00
abstract：AIMS AND OBJECTIVES:To identify general competence areas for graduating registered nurses and podiatrists providing chronic wound care. BACKGROUND:The provision of care for chronic wounds involves a team of multiple professionals, and registered nurses and podiatrists play an important role. However, previous studies ...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.14991
更新日期：2019-11-01 00:00:00
abstract：AIMS AND OBJECTIVES:This study aimed to identify and describe the experience of parents of children diagnosed with early onset scoliosis living in Australia. BACKGROUND:Chronic childhood disease has a major impact on health-related quality of life. Caring for a child with a chronic illness is well documented but the s...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.14301
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVES:To investigate family members' prioritisation of care in residential aged care facilities (RACFs). INTRODUCTION AND BACKGROUND:Family members are often involved in the care of their older relatives even after these relatives transit to a RACF. Understanding family members' priorities regarding care (i.e., w...
journal_title：Journal of clinical nursing
pub_type： 杂志文章,多中心研究
doi：10.1111/jocn.15352
更新日期：2020-09-01 00:00:00
abstract：AIMS AND OBJECTIVES:Aims of this study were to describe (a) the Romanian nurses' reasons for emigration and the difficulties experienced in the first six months of integration, (b) their perception of the level of professional independence and competence gained in the first six months of working and (c) the strategies ...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/j.1365-2702.2006.01647.x
更新日期：2007-12-01 00:00:00
abstract：AIM AND OBJECTIVES:This paper provides an overview of the current state of performance measurement, key trends and a methodological approach to leverage in efforts to generate a standardised data set for fundamental care. BACKGROUND:Considerable transformation is occurring in health care globally with organisations fo...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1111/jocn.14308
更新日期：2018-06-01 00:00:00
abstract：AIMS AND OBJECTIVES:To identify and synthesise the needs of care partners of older people living at home with assistance from home care services. BACKGROUND:"Ageing in place" is a promoted concept where care partners and home care services play significant roles. Identifying the needs of care partners and finding syst...
journal_title：Journal of clinical nursing
pub_type： 杂志文章,评审
doi：10.1111/jocn.14205
更新日期：2018-04-01 00:00:00
abstract：:The purpose of this research was to describe strategies used by sufferers of catastrophic illnesses and injuries. Participants were adult men and women with a variety of serious illnesses and injuries. Qualitative research approaches to data collection and data analysis, using grounded theory methods were employed. De...
journal_title：Journal of clinical nursing
pub_type： 杂志文章
doi：10.1046/j.1365-2702.2001.00536.x
更新日期：2001-09-01 00:00:00
