Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children.

abstract：AIM:To compare the antisecretory effects of rabeprazole and esomeprazole in an open, randomized, two-way crossover, clinical pharmacology study. METHODS:Twenty-four healthy subjects (14 men, 10 women; mean age 26.8 years) received rabeprazole 20 mg or esomeprazole 20 mg daily on days 1-5, with a 14-day 'wash-out'. Int...

journal_title：Alimentary pharmacology & therapeutics

authors： Warrington S,Baisley K,Boyce M,Tejura B,Morocutti A,Miller N

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:The role of mesalazine in preventing the clinical recurrence of Crohn's disease after surgery has been shown in a meta-analysis of all published studies. No clear relationship, however, has been shown between dosage and response. AIM:To evaluate whether 4.0 g/day of mesalazine may offer therapeutic advantag...

journal_title：Alimentary pharmacology & therapeutics

authors： Caprilli R,Cottone M,Tonelli F,Sturniolo G,Castiglione F,Annese V,Papi C,Viscido A,Cammà C,Corrao G,Latella G

更新日期：2003-02-15 00:00:00

abstract：AIM:To compare endoscopic banding ligation vs. no treatment in cirrhotics with intolerance or contraindications to beta-blockers for prevention of first bleeding in portal hypertension. METHODS:A sample size of 214 was planned with all sizes of varices. However, the trial was stopped due to increased bleeding in 52 pa...

journal_title：Alimentary pharmacology & therapeutics

authors： Triantos C,Vlachogiannakos J,Armonis A,Saveriadis A,Kougioumtzian A,Leandro G,Manolakopoulos S,Tzourmakliotis D,Raptis SA,Burroughs AK,Avgerinos A

更新日期：2005-06-15 00:00:00

abstract：:Faecal impaction with or without encopresis is a very common problem. We performed a randomized, open-label, prospective study to compare the efficacy and acceptability of the treatment of faecal impaction using either mineral oil or pineapple-flavoured isotonic intestinal lavage solution containing polyethylene glyco...

journal_title：Alimentary pharmacology & therapeutics

authors： Tolia V,Lin CH,Elitsur Y

更新日期：1993-10-01 00:00:00

abstract：:Haemochromatosis was first recognized as a disease entity over a century ago and its hereditary nature recognized over 60 years ago. However it was only in late 1996 that the haemochromatosis gene was cloned and a single C282Y mutation confirmed as being the cause of all HLA-linked iron overload in Caucasian populatio...

journal_title：Alimentary pharmacology & therapeutics

authors： George DK,Powell LW

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:In developed countries, hepatitis E is a porcine zoonosis caused by hepatitis E virus (HEV) genotype 3. In developing countries, hepatitis E is mainly caused by genotype 1, and causes increased mortality in patients with pre-existing chronic liver disease (CLD). AIM:To determine the role of HEV in patients ...

journal_title：Alimentary pharmacology & therapeutics

authors： Blasco-Perrin H,Madden RG,Stanley A,Crossan C,Hunter JG,Vine L,Lane K,Devooght-Johnson N,Mclaughlin C,Petrik J,Stableforth B,Hussaini H,Phillips M,Mansuy JM,Forrest E,Izopet J,Blatchford O,Scobie L,Peron JM,Dalton H

更新日期：2015-09-01 00:00:00

abstract：AIM:To measure 24-h ambulatory oesophageal pH data in patients with gastro-oesophageal reflux disease prior to, during and after acute treatment with comparable doses of omeprazole and ranitidine. METHODS:The subjects were 20 adults with at least 8% acid contact time. Ten subjects were treated for 1 week with omeprazo...

journal_title：Alimentary pharmacology & therapeutics

authors： Orr WC,Mellow MH,Grossman MR

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome is the most common diagnosis in gastroenterology. Trials suggest certain probiotics to be beneficial. AIM:To investigate the effects of multispecies probiotic supplementation (Lactobacillus rhamnosus GG, L. rhamnosus Lc705, Propionibacterium freudenreichii ssp. shermanii JS and Bifi...

journal_title：Alimentary pharmacology & therapeutics

authors： Kajander K,Myllyluoma E,Rajilić-Stojanović M,Kyrönpalo S,Rasmussen M,Järvenpää S,Zoetendal EG,de Vos WM,Vapaatalo H,Korpela R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Antibiotic resistance has increasingly been recognized as the major cause of treatment failure for Helicobacter pylori infection. New therapies for patients with metronidazole- or clarithromycin-resistant H. pylori are needed. AIM:To investigate the role of nitrofurantoin quadruple therapy for the treatment...

journal_title：Alimentary pharmacology & therapeutics

authors： Graham DY,Saeed MA,Hoffman J,El-Zimaity HM,Kwon DH,Osato MS

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Chronic continuous abdominal pain (CCAP) is characteristic of centrally mediated gastrointestinal pain disorders. It consumes significant healthcare resources yet is poorly understood, with minimal cohort-specific data in the literature. AIMS:To examine in a large cohort of CCAP patients, (a) diagnostic fea...

journal_title：Alimentary pharmacology & therapeutics

authors： Kilgallon E,Vasant DH,Green D,Shields PL,Hamdy S,Lal S,Paine P

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Sphincter of Oddi dysfunction is a benign, functional gastrointestinal disorder for which invasive endoscopic therapy with potential complications is often recommended. AIMS:To review the available evidence regarding the diagnostic accuracy of non-invasive methods that have been used to establish the diagno...

journal_title：Alimentary pharmacology & therapeutics

authors： Sgouros SN,Pereira SP

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:It is not clear whether the incidence or early mortality related to peptic ulcer perforation has changed. AIM:To evaluate the incidence and mortality related to peptic ulcer perforation while considering the intake of low-dose aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). METHODS:We recorded t...

journal_title：Alimentary pharmacology & therapeutics

authors： Taha AS,Angerson WJ,Prasad R,McCloskey C,Gilmour D,Morran CG

更新日期：2008-10-01 00:00:00

abstract：AIM:To assess the efficacy of the 8-week therapy with esomeprazole 40 mg vs. pantoprazole 40 mg for healing erosive oesophagitis (EE) as part of a management study. METHODS:Patients had a history of gastro-oesophageal reflux disease symptoms (> or =6 months) and had suffered heartburn on at least 4 of the 7 days prece...

journal_title：Alimentary pharmacology & therapeutics

authors： Labenz J,Armstrong D,Lauritsen K,Katelaris P,Schmidt S,Schütze K,Wallner G,Juergens H,Preiksaitis H,Keeling N,Nauclér E,Eklund S,Expo Study Investigators.

更新日期：2005-03-15 00:00:00

abstract：BACKGROUND:Drug toxicity is a well-known cause of acute pancreatitis (AP). Although many drugs have been associated with AP, the magnitude of the risk of most of them remains largely unknown. AIM:To determine the pancreatotoxic risk of a wide range of drugs. METHODS:The hospital-based Berlin case-control surveillance...

journal_title：Alimentary pharmacology & therapeutics

authors： Douros A,Bronder E,Andersohn F,Klimpel A,Thomae M,Ockenga J,Kreutz R,Garbe E

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Although lactulose and polyethylene glycol are osmotic laxatives widely used in the treatment of chronic constipation, no study has been conducted to compare their actions on the colonic bacterial ecosystem, which has an important influence on host health. AIM:To assess the effects of lactulose and polyethy...

journal_title：Alimentary pharmacology & therapeutics

authors： Bouhnik Y,Neut C,Raskine L,Michel C,Riottot M,Andrieux C,Guillemot F,Dyard F,Flourié B

更新日期：2004-04-15 00:00:00

abstract：:Six asymptomatic, non-smoking men with endoscopically proven duodenal ulcer disease received single nocturnal doses of placebo, 40 mg famotidine and 300 mg ranitidine each for 1 week prior to serial measurement of pH, peptic activity and serum gastrin concentrations over 24 h and of acid output. The intragastric pH fl...

journal_title：Alimentary pharmacology & therapeutics

authors： Thomson AB,Pinchbeck BR,Kirdeikis J,Zuk L,Marriage B,Prat A

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Gut microflora-mucosal interactions may be involved in the pathogenesis of irritable bowel syndrome (IBS). AIM:To investigate the efficacy of a novel prebiotic trans-galactooligosaccharide in changing the colonic microflora and improve the symptoms in IBS sufferers. METHODS:In all, 44 patients with Rome II...

journal_title：Alimentary pharmacology & therapeutics

authors： Silk DB,Davis A,Vulevic J,Tzortzis G,Gibson GR

更新日期：2009-03-01 00:00:00

abstract：:Intestinal failure is a specific disease entity resulting from intestinal resection or disease-associated malabsorption and characterized by the inability to maintain protein-energy, fluid, electrolyte or micronutrient balance. We performed a MEDLINE search (1966-2006) to identify relevant articles, using keywords int...

journal_title：Alimentary pharmacology & therapeutics

authors： Lal S,Teubner A,Shaffer JL

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Epidemiological data concerning hepatitis B are scarce in France. AIM:To describe epidemiological, clinical, virological and histological features of HBsAg-positive patients followed at non-academic hospitals in France. METHODS:Clinical, biological, virological and histological data of all HBsAg-positive c...

journal_title：Alimentary pharmacology & therapeutics

authors： Cadranel JF,Lahmek P,Causse X,Bellaiche G,Bettan L,Fontanges T,Medini A,Henrion J,Chousterman M,Condat B,Hervio P,Periac P,Eugène C,Moindrot H,Grasset D,Nouel O,Pilette C,Szostak-Talbodec N,Cayla JM,Si-Ahmed SN,Du

更新日期：2007-08-15 00:00:00

abstract：BACKGROUND:Ursodeoxycholic acid (UDCA) is able to improve biochemical markers of cholestasis, with a parallel decrease in transaminases, in various cholestatic liver diseases. AIM:To evaluate the effects of UDCA administration on acute viral hepatitis-related cholestasis and the course of acute viral hepatitis. METHO...

journal_title：Alimentary pharmacology & therapeutics

authors： Fabris P,Tositti G,Mazzella G,Zanetti AR,Nicolin R,Pellizzer G,Benedetti P,de Lalla F

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Fibroblast growth factors play an important role in (patho)physiological processes such as wound healing and tissue repair. We previously showed that basic fibroblast growth factor is actively involved in inflammatory bowel disease processes. In the present retrospective study, we assessed whether serum basi...

journal_title：Alimentary pharmacology & therapeutics

authors： Gao Q,Hogezand RA,Lamers CB,Verspaget HW

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Following a nil per os (NPO) regimen, most patients with acute pancreatitis (AP) can resume normal oral intake within 1 week. If not tolerated, it is recommended to initiate artificial feeding, preferably by the enteral route. AIM:To evaluate the nutritional management of patients with AP in a Dutch cohort ...

journal_title：Alimentary pharmacology & therapeutics

authors： Spanier BW,Mathus-Vliegen EM,Tuynman HA,Van der Hulst RW,Dijkgraaf MG,Bruno MJ,EARL Study Group.

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:One-week low-dose proton pump inhibitor-based triple therapies have usually proved to be effective treatments for Helicobacter pylori infection. AIM:To investigate the eradication efficacy, safety profile and patient compliance of two triple therapies containing a standard dose of rabeprazole and a new fluo...

journal_title：Alimentary pharmacology & therapeutics

authors： Cammarota G,Cianci R,Cannizzaro O,Cuoco L,Pirozzi G,Gasbarrini A,Armuzzi A,Zocco MA,Santarelli L,Arancio F,Gasbarrini G

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:In cirrhosis, portal hypertension is associated with a spectrum of renal dysfunction that has significant implications for morbidity and mortality. AIM:To discuss recent progress in the patho-physiological mechanisms and therapeutic options for portal hypertension-related renal dysfunction. METHODS:A liter...

journal_title：Alimentary pharmacology & therapeutics

authors： Leithead JA,Hayes PC,Ferguson JW

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Minimal hepatic encephalopathy (MHE) is characterised by subtle neurocognitive deficits without overt clinical manifestations. Although several trials have individually evaluated the role of prebiotics, probiotics and synbiotics, there is yet no consensus on the management of MHE. AIM:To estimate the effica...

journal_title：Alimentary pharmacology & therapeutics

authors： Shukla S,Shukla A,Mehboob S,Guha S

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The herbal treatment with myrrh, dry extract of chamomile flowers and coffee charcoal has anti-inflammatory and antidiarrhoeal potential and might benefit patients with UC. Aminosalicylates are used as standard treatment for maintaining remission in ulcerative colitis (UC). AIM:To compare the efficacy of th...

journal_title：Alimentary pharmacology & therapeutics

authors： Langhorst J,Varnhagen I,Schneider SB,Albrecht U,Rueffer A,Stange R,Michalsen A,Dobos GJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori eradication improves dyspeptic symptoms in 8%-10%, prevents peptic ulcer and may reduce the risk of gastric cancer. Availability of a high quality diagnostic test and an effective treatment makes population screening and eradication of Helicobacter pylori an attractive option. AIM:To eva...

journal_title：Alimentary pharmacology & therapeutics

authors： Høgh MB,Kronborg C,Hansen JM,Schaffalitzky de Muckadell OB

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Methotrexate (MTX) is one of the most frequently prescribed drugs in contemporary medicine with a well-recognised hepatotoxic potential, for which stringent laboratory and histological surveillance has long been advocated. AIM:To estimate the population burden of end-stage methotrexate-related liver disease...

journal_title：Alimentary pharmacology & therapeutics

authors： Dawwas MF,Aithal GP

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Recently, a rapid-release 100-mg 13C-urea tablet with citrate supplement (Diabact UBT) showed excellent performance in a European population. AIM:To investigate the accuracy of a 50-mg tablet-based 13C-urea breath test protocol. METHODS:: Consecutive dyspeptic patients referred for upper endoscopy were rec...

journal_title：Alimentary pharmacology & therapeutics

authors： Wong WM,Lam SK,Lai KC,Chu KM,Xia HH,Wong KW,Cheung KL,Lin SK,Wong BC

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Previous data have indicated low bone formation as a mechanism of osteoporosis in inflammatory bowel disease. Fluoride can stimulate bone formation. AIM:To assess the effect of fluoride supplementation on lumbar spine bone mineral density in osteoporotic patients with inflammatory bowel disease treated in p...

journal_title：Alimentary pharmacology & therapeutics

authors： Abitbol V,Mary JY,Roux C,Soulé JC,Belaiche J,Dupas JL,Gendre JP,Lerebours E,Chaussade S,Groupe D'etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID).

更新日期：2002-05-01 00:00:00