A simple mathematical approach to deciding the dosage of vaccine against pandemic H1N1 influenza.

Abstract:

:Results from early clinical trials have shown that a single dose of pandemic H1N1 influenza vaccine may generate sufficient antibody response, but the relevance of this fact to public health decision making has yet to be clarified. The present study compares the risk of clinical attack (i.e. clinical attack rate) between one- and two-dose vaccination schemes. If the efficacies do not greatly vary between one- and two-dose schemes, one-dose vaccination may well be supported. Nevertheless, two-dose vaccination is shown to result in less morbidity if the vaccine efficacies are greatly diminished by reducing the dose. As long as the detailed efficacy estimates rest on theoretical assumptions, single-dose vaccination may only be sufficiently justified in a specific setting where the number of vaccines is extremely limited.

journal_name

Euro Surveill

authors

Nishiura H,Iwata K

doi

10.2807/ese.14.45.19396-en

subject

Has Abstract

pub_date

2009-11-12 00:00:00

issue

45

eissn

1025-496X

issn

1560-7917

journal_volume

14

pub_type

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