Abstract：
:The specific role of dietary fat in breast cancer progression is unclear, although a low-fat diet was associated with decreased recurrence of estrogen receptor alpha negative (ER(-)) breast cancer. ER(-) basal-like MDA-MB-231 and MDA-MB-436 breast cancer cell lines contained a greater number of cytoplasmic lipid droplets compared to luminal ER(+) MCF-7 cells. Therefore, we studied lipid storage functions in these cells. Both triacylglycerol and cholesteryl ester (CE) concentrations were higher in the ER(-) cells, but the ability to synthesize CE distinguished the two types of breast cancer cells. Higher baseline, oleic acid- and LDL-stimulated CE concentrations were found in ER(-) compared to ER(+) cells. The differences corresponded to greater mRNA and protein levels of acyl-CoA:cholesterol acyltransferase 1 (ACAT1), higher ACAT activity, higher caveolin-1 protein levels, greater LDL uptake, and lower de novo cholesterol synthesis in ER(-) cells. Human LDL stimulated proliferation of ER(-) MDA-MB-231 cells, but had little effect on proliferation of ER(+) MCF-7 cells. The functional significance of these findings was demonstrated by the observation that the ACAT inhibitor CP-113,818 reduced proliferation of breast cancer cells, and specifically reduced LDL-induced proliferation of ER(-) cells. Taken together, our studies show that a greater ability to take up, store and utilize exogenous cholesterol confers a proliferative advantage to basal-like ER(-) breast cancer cells. Differences in lipid uptake and storage capability may at least partially explain the differential effect of a low-fat diet on human breast cancer recurrence.
journal_name
Breast Cancer Res Treatjournal_title
Breast cancer research and treatmentauthors
Antalis CJ,Arnold T,Rasool T,Lee B,Buhman KK,Siddiqui RAdoi
10.1007/s10549-009-0594-8subject
Has Abstractpub_date
2010-08-01 00:00:00pages
661-70issue
3eissn
0167-6806issn
1573-7217journal_volume
122pub_type
杂志文章abstract：:Tumor formation can result from a decrease in cell death, as well as an increase in cell proliferation. In spite of the high incidence of mammary gland tumors (MGTs) in female dogs, the understanding of its etiology is still poor. Consistent with several proto-oncogenes (such as Wnt) for the mammary gland, sFRP2 is ex...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-006-9233-9
更新日期：2006-11-01 00:00:00
abstract：PURPOSE:The separate impacts of dose and dose intensity of chemotherapy for metastatic breast cancer remain uncertain. The primary objective of this trial was to compare a short, high-dose, intensive course of epirubicin and cyclophosphamide (EC) with a longer conventional dose regimen delivering the same total dose of...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10549-019-05187-y
更新日期：2019-07-01 00:00:00
abstract：:The structure/activity relationships for inhibition of aromatase and cholesterol side-chain cleavage enzyme (CSCC) by aminoglutethimide and some of its analogues are reviewed. Although more effective against aromatase than CSCC, aminoglutethimide markedly inhibits both enzymes. Optimal competitive antagonism of aromat...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Thrombospondin-1 (TSP-1) has been proposed to have both pro-metastatic and anti-metastatic properties. To elucidate its role in breast cancer metastasis, we compared tumor progression in the polyomavirus middle T antigen (Pyt) transgenic mouse and the TSP-1-null Pyt transgenic mouse. We characterized the tumors in the...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-008-9992-6
更新日期：2009-03-01 00:00:00
abstract：:Clinical evidence indicates that higher levels of estrogen receptor beta (ERbeta) predicts improved disease-free and overall survival in patients treated with adjuvant tamoxifen therapy. To better understand the mechanisms in which ERbeta can modulate breast cancer therapies, we introduced ERbeta under an inducible pr...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-007-9640-6
更新日期：2008-05-01 00:00:00
abstract：PURPOSE:The Ki67 proliferation index is a prognostic and predictive marker in breast cancer. Manual scoring is prone to inter- and intra-observer variability. The aims of this study were to clinically validate digital image analysis (DIA) of Ki67 using virtual dual staining (VDS) on whole tissue sections and to assess ...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-018-4669-2
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:The objective of this study is to understand an impact of financial burden on the adjuvant hormonal therapy (AHT) adherence and persistence for insured women aged 18-64 with early breast cancer in Texas. METHODS:We conducted a retrospective cohort study using claims data for population insured by Blue Cross Bl...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-018-4704-3
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:Vitamin D (VD) metabolism regulates adipose tissue, lipogenesis inflammation, and tumor growth. CYP24A1 is the key enzyme for metabolic inactivation of active VD (1,25(OH)2D3). We examined whether common germline single nucleotide polymorphisms (SNPs) in the CYP24A1 gene could affect the association between adu...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-019-05484-6
更新日期：2020-01-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-017-4413-3
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-011-1581-4
更新日期：2011-11-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01806938
更新日期：1982-01-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-020-05746-8
更新日期：2020-08-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-016-3890-0
更新日期：2016-07-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-020-05543-3
更新日期：2020-04-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,评审
doi：10.1023/a:1005865812918
更新日期：1997-08-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-020-05830-z
更新日期：2020-10-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,评审
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更新日期：2020-10-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01961245
更新日期：1992-01-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-014-3104-6
更新日期：2014-09-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2005-09-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,评审
doi：10.1007/s10549-008-0268-y
更新日期：2009-07-01 00:00:00
abstract：:Patients from hereditary breast cancer-prone (HBC) families provide one of the most powerful and potentially cost effective models for cancer prevention and control. Paradoxically, this opportunity is often missed in the clinical practice setting due, in part, to inattention to the family history and/or lack of knowle...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01810778
更新日期：1990-02-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-020-05654-x
更新日期：2020-06-01 00:00:00
abstract：:Mutations in the BRCA1 and BRCA2 genes account for the majority of hereditary breast ovarian cancer (HBOC) cases. However, after BRCA1 and BRCA2 screening still the most HBOC cases remain negative for any mutational event. Accordingly, in these cases raises the relevance to analyze the unusual BRCA1/2 variants of unce...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-008-0244-6
更新日期：2010-01-01 00:00:00
abstract：:The use of molecular components from both normal and neoplastic breast tissue as markers for breast tumors has long been recognized as of major potential for breast cancer diagnosis, and has been an area of active research. Recent developments in immunological approaches have further stimulated this field by permittin...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01806776
更新日期：1985-01-01 00:00:00
