Abstract：
:In a study carried out for patients receiving intrafamilial HLA-A,B,DR identical, MLC negative bone marrow transplants, RFLP profiles of HLA-class II for 27 donor recipient pairs were analyzed. Twenty-four pairs were found HLA-class II identical while three pairs were HLA-DP incompatible. The patients of these three pairs did not reveal any acute GVHD greater than or equal to grade II. The seven cases of acute GVHD greater than or equal to grade II found in our panel were HLA-DR, DQ, and DP compatible. Thus, in practical terms pretransplantation HLA-DP typing does not seem necessary for intrafamilial HLA-identical, MLC negative BMT. On the other hand, this work confirmed that it is possible to type for HLA-DP using molecular biological techniques, and this in itself may have some important implications for unrelated BMT.
journal_name
Leukemiajournal_title
Leukemiaauthors
al-Daccak R,Loiseau P,Soulie A,Varrin F,Rabian C,Raffoux C,Cohen D,Degos L,Gluckman E,Colombani Jsubject
Has Abstractpub_date
1990-03-01 00:00:00pages
222-6issue
3eissn
0887-6924issn
1476-5551journal_volume
4pub_type
杂志文章相关文献
LEUKEMIA文献大全abstract：:The MDM2 gene is a gene whose product binds to p53 and regulates its function. Amplification of MDM2 has been found in human sarcomas, where it leads to inactivation of p53. In 64 cases of generally advanced myelodysplastic syndromes, we found no amplification or rearrangement of MDM2 gene by Southern analysis. MDM2 R...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:We have cloned two genes for cell surface molecules, capable of delivering the intracellular signals, which are modulated for their expression by Tax. One is the gamma chain of the interleukin-2 (IL-2) receptor which is suggested to be critical for IL-2-dependent growth of human T-cell leukemia virus type I (HTLV-I) i...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:Follicular lymphoma is a low grade malignancy characterized by the translocation t(14;18), which involves the putative oncogene bcl-2. We describe a 73-year-old patient presenting with Burkitt acute lymphoblastic leukemia (B-ALL) L3 (Burkitt type), whose cells had the following immunophenotype: CD19+, CD22+, HLA-DR+, ...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:Fas ligand (FasL) is capable of inducing apoptosis of lymphoid cells by cross-linking with its natural receptor, Fas. We aimed to investigate the possible role of the Fas/FasL-mediated apoptosis in the development of human lymphomas. FasL mRNA was detected by reverse transcriptase-polymerase chain reaction in 38 out o...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2400815
更新日期：1997-11-01 00:00:00
abstract：:We analyzed the TS-2 acute lymphoblastic leukemia (ALL) cell line that contains a t(1;19)(q23;p13.3) but lacks E2A-PBX1 fusion typically present in leukemias with this translocation. We found that the t(1;19) in TS-2 fuses the 19p13 gene DAZAP1 (Deleted in Azoospermia-Associated Protein 1) to the 1q23 gene MEF2D (Myoc...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2403684
更新日期：2005-05-01 00:00:00
abstract：:The introduction of BCR-ABL tyrosine kinase inhibitors has revolutionized the treatment of chronic myeloid leukemia (CML). A major clinical aim remains the identification and elimination of low-level disease persistence, termed "minimal residual disease". The phenomenon of disease persistence suggests that despite tar...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/s41375-019-0684-5
更新日期：2020-06-01 00:00:00
abstract：:We studied changes in peripheral blood and bone marrow biopsy specimens obtained before, during, and after recombinant alpha 2b-interferon (IFN-alpha 2b) therapy in 25 patients with hairy cell leukemia. During therapy, only 1 patient showed no improvement in at least one of the parameters monitored. Granulocytopenia, ...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:The Wilms' tumor gene, WT1, is a tumor marker for leukemic blast cells. The WT1 expression levels were examined for 57 patients with myelodysplastic syndromes (MDS) (refractory anemia (RA), 35; RA with excess of blasts (RAEB) 14; RAEB in transformation (RAEB-t), six; and MDS with fibrosis, two) and 12 patients with ac...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401341
更新日期：1999-03-01 00:00:00
abstract：:The human factor-dependent leukemia cell line UCSD/AML1 contains the t(3;3) (q21;q26) characteristic of the syndrome of acute leukemia with high platelets. The human homologue of the murine leukemia oncogene evi-1 was recently localized to chromosome 3q24-3q28 and transcription of evi-1 is a frequent event in mouse-re...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:Clonal chromosome abnormalities were detected in bone marrow cells of 20 patients with Fanconi anemia investigated at various stages of the disease. Two presented with acute leukemia, six with myelodysplastic syndrome, and 12 had minor or no morphological abnormalities of hematopoietic cells. Abnormalities of chromoso...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：:Large granular lymphocyte leukemia (LGLL) is a rare and chronic lymphoproliferative disorder characterized by the clonal expansion of LGLs. LGLL patients can be asymptomatic or develop cytopenia, mostly neutropenia. Somatic STAT3 and STAT5b mutations have been recently reported in approximately 40% of patients. The ai...
journal_title：Leukemia
pub_type： 临床试验,杂志文章
doi：10.1038/s41375-019-0644-0
更新日期：2020-04-01 00:00:00
abstract：:Dasatinib treatment markedly increases the number of large granular lymphocytes (LGLs) in a proportion of Ph+ leukemia patients, which associates with a better prognosis. The lymphocytosis is predominantly observed in cytomegalovirus (CMV)-seropositive patients, yet detectable CMV reactivation exists only in a small f...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2016.174
更新日期：2017-01-01 00:00:00
abstract：:Transformation of post-myeloproliferative neoplasms into secondary (s) AML exhibit poor clinical outcome. In addition to increased JAK-STAT and PI3K-AKT signaling, post-MPN sAML blast progenitor cells (BPCs) demonstrate increased nuclear β-catenin levels and TCF7L2 (TCF4) transcriptional activity. Knockdown of β-caten...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/s41375-018-0334-3
更新日期：2019-06-01 00:00:00
abstract：:Because of their substantial in vitro synergy, we conducted a dose-escalation study of cyclophosphamide (CP) added to 2-chloro-2'-deoxyadenosine (CdA) in patients with previously treated chronic lymphocytic leukemia and non-Hodgkin's lymphoma. CdA was given at a fixed dose (5.6 mg/m2/day) as a 2-h intravenous (i.v.) i...
journal_title：Leukemia
pub_type： 临床试验,杂志文章
doi：10.1038/sj.leu.2401783
更新日期：2000-06-01 00:00:00
abstract：:To evaluate current detection methods for FIP1L1-PDGFRA in hypereosinophilic syndrome (HES), we developed a means to rapidly amplify genomic break points. We screened 202 cases and detected genomic junctions in all samples previously identified as RT-PCR positive (n=43). Genomic fusions were amplified by single step P...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2008.309
更新日期：2009-02-01 00:00:00
abstract：:In the present study, 89 patients with generalized immunocytoma were analyzed retrospectively for the prognostic influence of clinical features and of immunophenotype using bone marrow biopsies. Univariate analysis selected the following variables as significant for survival: age over 60 years (p = 0.021), Rai and Bin...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:Hematopoietic stem cells are identified based on their functional ability to migrate via the blood circulation of transplanted recipients, to home to the host bone marrow and to durably repopulate this organ with high levels of maturing myeloid and lymphoid cells. While a small pool of undifferentiated stem cells with...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/sj.leu.2402684
更新日期：2002-10-01 00:00:00
abstract：:Allogeneic stem cell transplantation for acute myeloid leukemia (AML) using reduced-intensity conditioning (RIC) is based on the strategy of attaining donor cell engraftment with immunosuppressive agents. This approach, which relies predominantly on donor effector cells for anti-leukemic or graft-versus-leukemia effec...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/sj.leu.2404328
更新日期：2006-10-01 00:00:00
abstract：:This report documents the follow-up information on 69 hairy cell leukemia (HCL) patients treated with interferon alpha-2b (IFN) as primary treatment from 1983-86. Follow-up through October 1991 shows only 11 patients have died. Forty-one of the 57 patients completing the intended 12 or more months of initial IFN treat...
journal_title：Leukemia
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:We describe two new human leukemia cell lines, MOLM-13 and MOLM-14, established from the peripheral blood of a patient at relapse of acute monocytic leukemia, FAB M5a, which had evolved from myelodysplastic syndrome (MDS). Both cell lines express monocyte-specific esterase (MSE) and MLL-AF9 fusion mRNA. Gene fusion is...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2400768
更新日期：1997-09-01 00:00:00
abstract：:The aim was to determine the efficacy and safety of decitabine in the settings of relapse post-allogeneic progenitor cell transplantation or as part of the conditioning regimen. Three patients (two AML, one ALL) received single agent decitabine 1000 mg/m2 total dose) for treatment of relapse post-transplant (group 1)....
journal_title：Leukemia
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:In most cases of lymphomas with blood dissemination, the careful cytological analysis of peripheral blood smears provides a rapid orientation to diagnosis, even if the final subtyping is achieved by histology and eventually other techniques. Here, we evaluated if the analysis of blood smears may suggest the blood diss...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2404013
更新日期：2006-02-01 00:00:00
abstract：:We have used a 4-day MTT colorimetric assay to study drug sensitivity of leucocytes from leukaemia patients and from normal donors. Response to Adriamycin, vincristine, aclacinomycin A, 3'-deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin (MX2), and melphalan has been determined, together with the effects of the r...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Allogeneic haemopoietic cell transplant (allo-HCT) may be curative in acute myeloid leukaemia (AML) in second complete remission (CR2) but the impact of reduced intensity (RIC) versus myeloablative conditioning (MAC) is uncertain. The Acute Leukaemia Working Party of the European Society for Blood and Bone Marrow Tran...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/s41375-019-0527-4
更新日期：2020-01-01 00:00:00
abstract：:Despite recent advances in our understanding of the molecular and biological abnormalities in chronic myelogenous leukemia (CML) this new knowledge has not yet led to significant improvements in treatment. We have reviewed what is known and still unknown about the molecular and biological abnormalities in CML that may...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：
更新日期：1993-11-01 00:00:00
abstract：:Translocation (15;17)(q22;q12-q21) is a chromosome aberration specifically found in acute promyelocytic leukemia (APL), that generates a chimeric gene between the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor alpha (RARA) gene, on chromosome 17. In the course of molecular investigat...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Molecular rearrangements of Ph1 chromosome, the hallmark of CML, are clustered in a 5.8-kb DNA segment, the so-called breakpoint cluster region (bcr) of the phl gene that is localized to chromosome 22q11. In Ph1-positive (Ph1+) ALLs, the rearrangements have been shown to involve either the 5.8-kb bcr (called bcr+) or ...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:We have investigated the protective effect of human T-cell leukemia virus I (HTLV-I) immune globulin (HTLVIG) against HTLV-I in rabbits. HTLVIG containing 77 mg/ml of IgG was prepared from pooled plasma from seropositive healthy persons. In the first experiment, four groups (A, B, C, and D) of three rabbits were trans...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:It has been reported that stroma-dependent cultures support proliferation of hematopoietic stem cells (HSC). In order to investigate the effect of soluble stromal factors, we developed short-term serum-low liquid cultures in which the effect of stroma-conditioned media (SCM) from the murine FBMD-1, and human L87/4 and...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2400530
更新日期：1997-01-01 00:00:00
abstract：:We report here the case of a 55-year-old patient with chronic granular lymphocyte disorder associated with moderate neutropenia. The majority of peripheral blood lymphocytes displayed a CD3-, CD8-, CD16+, CD56(NKH1)- phenotype. The patient's cells showed high spontaneous cytotoxic activity against K562 targets and dev...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
