当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY期刊下所有文献 > A systematic review of neonatal toxoplasmosis exposure and sensorineural hearing loss.

A systematic review of neonatal toxoplasmosis exposure and sensorineural hearing loss.

Abstract：

INTRODUCTION:The Joint Committee on Infant Hearing 2007 Position Statement includes in utero toxoplasmosis infection as a risk indicator for delayed-onset or progressive sensorineural hearing loss. It is recommended that children with congenital toxoplasmosis infection undergo audiologic monitoring to identify congenital and delayed-onset sensorineural hearing loss. OBJECTIVE:To determine the prevalence of sensorineural hearing loss and to develop evidence-based guidelines for audiologic monitoring of children born with congenital toxoplasmosis infection. DATA SOURCES:Systematic search of Medline, EMBASE and Cochrane databases and manual search of references. STUDY SELECTION:Longitudinal studies reporting an inception cohort identified at birth, with serologic confirmation of toxoplasmosis infection, and long-term serial audiometric evaluation. DATA EXTRACTION:Independent extraction of patient and audiometric data. DATA SYNTHESIS:Descriptive statistics. CONCLUSION:The five studies meeting our inclusion criteria report a prevalence of toxoplasmosis-associated hearing loss from 0% to 26%. Improved treatment regimens for toxoplasmosis may account for this range. Three treatment groups were identified and a subgroup analysis of the compiled data was performed. In children receiving limited or no treatment, the prevalence of toxoplasmosis-associated SNHL was found to be 28%. In children prescribed 12 months of antiparasitic treatment but in whom treatment was not confirmed to have started prior to 2.5 months of age and in whom compliance was not ensured, the prevalence of SNHL was 12%. In children treated with 12 months of antiparasitical therapy initiated prior to 2.5 months of age with serologically-confirmed compliance, the prevalence of SNHL was 0%. Only two longitudinal studies were identified and neither reported any cases of delayed-onset or progressive toxoplasmosis-associated SNHL. Children who have received a 12-month course of antiparasitical therapy initiated prior to 2.5 months with serologically-confirmed compliance should have repeat audiometric evaluation at 24-30 months of age. Children with congenital toxoplasmosis that had no treatment, partial treatment, delayed onset of treatment, or compliance issues should undergo annual audiologic monitoring until able to reliably self-report hearing loss.

journal_name

Int J Pediatr Otorhinolaryngol

journal_title

International journal of pediatric otorhinolaryngology

authors

Brown ED,Chau JK,Atashband S,Westerberg BD,Kozak FK

doi

10.1016/j.ijporl.2009.01.012

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

707-11

issue

eissn

0165-5876

issn

1872-8464

pii

S0165-5876(09)00015-9

journal_volume

pub_type

杂志文章,评审

在线工具

A systematic review of neonatal toxoplasmosis exposure and sensorineural hearing loss.