Abstract：
:An aqueous gel formulation containing solubilized clindamycin phosphate 1.2% and a stable combination of both solubilized and crystalline tretinoin 0.025% (clin/tret) has been evaluated in 3 pivotal phase 3 studies, among other studies including a 52-week trial. The pivotal studies enrolled 4550 participants 12 years and older with mild, moderate, and severe acne vulgaris. The combination clin/tret gel was effective in reducing both inflammatory and noninflammatory lesions and was well-tolerated. This article reviews important vehicle characteristics of the combination gel as well as formulation stability and tolerability data that are potentially clinically relevant.
journal_name
Cutisjournal_title
Cutisauthors
Del Rosso JQ,Jitpraphai W,Bhambri S,Momin Ssubject
Has Abstractpub_date
2008-05-01 00:00:00pages
405-8issue
5eissn
0011-4162issn
2326-6929journal_volume
81pub_type
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