Abstract:
INTRODUCTION:Several reports indicated that interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF- alpha) play important regulatory roles in bone remodeling and homeostasis. In addition, receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG) have been shown to be important regulators of osteoclastogenesis during bone remodeling, and their expressions were examined during fracture healing in a mouse model of tibial fracture. However, studies linking RANKL, OPG, IL-6 and TNF-alpha in patients with head injury and fracture are lacking. PATIENTS AND METHODS:Within the first few hours of admission to hospital and at 4, 8, and 12 weeks after the injury, we evaluated changes in serum levels of RANKL, OPG, IL-6 and TNF-alpha in 24 male patients with a concomitant head injury and fracture and in 26 male patients with fracture only. These levels were compared with those found in 36 healthy controls. RESULTS:The RANKL/OPG ratios were found to significantly lower in patients with a concomitant head injury and fracture than in the controls immediately after admission and at 4, 8, and 12 weeks after the injury. In addition, RANKL/OPG ratios were significantly lower in patients with a concomitant head injury and fracture than in those with fracture at 8 and 12 weeks after the injury. The serum IL-6 levels were significantly higher in patients with a concomitant head injury and fracture than in the controls upon admission, and at 4, 8, and 12 weeks after the injury. Moreover, the serum IL-6 levels were significantly higher in patients with a head injury and fracture than in those with just a fracture at 4, 8, and 12 weeks after the injury. CONCLUSIONS:Based on these changes in the profiles of RANKL, OPG, and IL-6 and the RANKL/OPG ratio, altered repair of a fracture can occur in patients with a concomitant head injury and fracture.
journal_name
Arch Orthop Trauma Surgjournal_title
Archives of orthopaedic and trauma surgeryauthors
Lee JS,Ryu CH,Moon NH,Kim SJ,Park SY,Suh KTdoi
10.1007/s00402-008-0632-8subject
Has Abstractpub_date
2009-05-01 00:00:00pages
711-8issue
5eissn
0936-8051issn
1434-3916journal_volume
129pub_type
杂志文章abstract::Fractures of the distal radius are extremely common injuries, which are steadily becoming a public health issue. One of the most common complications following distal radius fractures is still malunion of the distal radius. This review of the literature surrounding distal radius malunion covers the biomechanics of dis...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章,评审
doi:10.1007/s00402-012-1466-y
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:The number of total hip and knee arthroplasties (THA and TKA) is steadily increasing. Many factors that influence pain have been reported, but little is known about the correlation between the time of day and the duration of surgery and postoperative pain. On one hand, surgical interventions are performed faste...
journal_title:Archives of orthopaedic and trauma surgery
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doi:10.1007/s00402-017-2769-9
更新日期:2017-10-01 00:00:00
abstract:INTRODUCTION:Porcine flexor tendons, bovine extensor tendons, and human (semitendinosus) tendons are frequently used as substitutes for human ACL grafts in biomechanical in vitro studies. This study compares the biomechanical properties and structural differences of these tendons. MATERIALS AND METHODS:In this biomech...
journal_title:Archives of orthopaedic and trauma surgery
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abstract:INTRODUCTION:An intact distal radioulnar joint (DRUJ) is essential for normal functioning of the upper limb. Osteoarthritis of the DRUJ often leads to ulnar wrist pain, limitation of forearm rotation and reduced grip strength, all of which limit activities of daily living. Once the joint is damaged, salvage procedures ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-003-0529-5
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abstract:BACKGROUND:Flexible flatfoot is a frequent deformity found in children. The aim of this study is to evaluate the pedographic outcome of the percutaneous arthroereisis with the use of a screw through the sinus tarsi into the talus. MATERIALS AND METHODS:43 calcaneo-stop procedures of 25 patients (18 bilateral, seven un...
journal_title:Archives of orthopaedic and trauma surgery
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doi:10.1007/s00402-011-1316-3
更新日期:2011-10-01 00:00:00
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journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-020-03688-w
更新日期:2020-11-23 00:00:00
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journal_title:Archives of orthopaedic and trauma surgery
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更新日期:1991-01-01 00:00:00
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journal_title:Archives of orthopaedic and trauma surgery
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journal_title:Archives of orthopaedic and trauma surgery
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journal_title:Archives of orthopaedic and trauma surgery
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abstract::We present a patient with massive posttraumatic ectopic calcification in the lower extremity. The patient complained of an increasing tender soft tissue mass with signs of acute inflammation and foot dorsiflexion weakness following a tibial fracture for 34 years. A large radiopaque mass was resected and reconstructed ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-006-0228-0
更新日期:2007-01-01 00:00:00
abstract::Acetabular, femoral and tibial torsion of 50 normal adult male subjects were measured by computerized tomography and the relationship between these angles and foot-progression angle was examined. The mean acetabular anteversion was 15.6 degrees on the right and 15.8 degrees on the left, (range 3 degrees-30 degrees). T...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s004020050459
更新日期:2000-01-01 00:00:00
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journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-008-0580-3
更新日期:2009-01-01 00:00:00
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journal_title:Archives of orthopaedic and trauma surgery
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doi:10.1007/s00402-007-0528-z
更新日期:2008-04-01 00:00:00
abstract::The cortical bone area of the middle femur was investigated with computed tomography in 12 patients after hip rearthroplasty due to aseptic prosthetic loosening. The patients had undergone their original arthroplasty because of unilateral arthrosis 11 years before these measurements. Both legs were scanned, and the re...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00422836
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:Although it is well known from cadaveric and biomechanical studies that transtibial femoral tunnel (TT) positioning techniques are associated with non-anatomic tunnel positions, controversial data exist as so far no clinical differences could have been found, comparing transtibial with anteromedial techniq...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-017-2738-3
更新日期:2017-09-01 00:00:00
abstract::In the period 1969-1991, 46 extensor indicis proprius tendon transfers were performed for functional loss of extensor pollicis longus. The long-term function of the thumb was reviewed in 22 patients with an average follow-up of 7 years. Based on Geldmacher's evaluation scheme for assessment of the results of extensor ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/BF00426181
更新日期:1994-01-01 00:00:00
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journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-015-2385-5
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journal_title:Archives of orthopaedic and trauma surgery
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journal_title:Archives of orthopaedic and trauma surgery
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doi:10.1007/BF00571479
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journal_title:Archives of orthopaedic and trauma surgery
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journal_title:Archives of orthopaedic and trauma surgery
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更新日期:2021-01-23 00:00:00
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journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s004020050401
更新日期:1999-01-01 00:00:00
abstract::The purpose of this study was to evaluate the osteopenia in several parts of the shoulder joint in a series of individuals suffering from frozen shoulder and to elucidate the pathogenesis. The bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DEXA). In 30 cases of frozen shoulder, 16 men and...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s004020050430
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Femoral fractures in polio survivors present unique challenges; the bone is often small, deformed, osteoporotic and hypovascularized. Locked compression plating aided in achieving a better construct stability of osteoporotic fractures. METHODS:A total of 13 unilateral femoral fractures in adult polio patien...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-010-1126-z
更新日期:2010-10-01 00:00:00
abstract::The authors present an experimental study of 30 rats, in which human dura mater preserved in glycerin was used to repair gaps in the Achilles tendon. The animals were killed 8 weeks after the surgery and evaluated by gross and microscopic examination. The results showed that the dura mater did not cause foreign-body r...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/BF00440572
更新日期:1990-01-01 00:00:00
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journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-014-2046-0
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:Patients with knee osteoarthritis tend to modify spatial and temporal parameters during walking to reduce the pain. Total knee arthroplasty (TKA) is considered the gold standard treatment for end-stage knee osteoarthritis. However, reduced physical function of the knee is partly, but apparently not fully, ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-017-2629-7
更新日期:2017-03-01 00:00:00
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journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-015-2266-y
更新日期:2015-09-01 00:00:00