Abstract:
OBJECTIVE:To determine whether methodological differences explain divergent results in case-control studies examining surgery as a risk factor for Creutzfeldt-Jakob disease (CJD). METHODS:After case-control studies were systematically identified using PubMed, we performed a homogeneity analysis and applied models to effect sizes (odds ratio [OR] with 95% confidence interval [CI]) using 2 parameters: type of control subject used and consistency of data ascertainment. The hospitals and communities were located in Europe, Japan, and Australia. Patients were CJD case subjects and age- and sex-matched control subjects in the hospital or community. Because of the natural history of the disease, CJD subjects are not considered reliable sources of information for these studies. Therefore, individuals who are considered close to the subjects and who have knowledge of their medical history, including spouses and relatives, are necessarily identified as proxy informants for the surgical record of the case subjects. RESULTS:Overall, the effect sizes lacked homogeneity (P<.0001). Three studies that used control subjects from the community revealed a significantly elevated risk of CJD for patients who underwent surgery (OR, 1.82; 95% CI, 1.41-2.35 [P<.0001]), whereas 3 investigations that used control subjects from the hospital revealed a significantly reduced risk (OR, 0.69; 95% CI, 0.52-0.90 [P=.0069]). Two studies that used proxy informants to acquire information about case subjects and control subjects (consistent ascertainment) found that the risk of CJD was significantly lower in those subjects who underwent surgery (OR, 0.65; 95% CI, 0.48-0.87 [P=.0043]). Conversely, 4 studies in which proxy informants acted only on behalf of case subjects (inconsistent data ascertainment) found a significant positive association between surgery and CJD (OR, 1.67; 95% CI, 1.32-2.12 [P<.0001]). Both models fit the data very well, leaving no remaining variance in effect sizes to explain. CONCLUSION:Variation in the type of control subjects used and in exposure assessment in case-control studies may partially explain conflicting data regarding the association between surgery and CJD. However, there was almost complete confounding of these 2 parameters, making interpretation more difficult. Planning of future investigations must carefully consider these design elements.
journal_name
Infect Control Hosp Epidemioljournal_title
Infection control and hospital epidemiologyauthors
Barash JA,Johnson BT,Gregorio DIdoi
10.1086/527514subject
Has Abstractpub_date
2008-03-01 00:00:00pages
212-8issue
3eissn
0899-823Xissn
1559-6834journal_volume
29pub_type
杂志文章abstract:OBJECTIVE:To determine whether hydrogen peroxide vapor (HPV) decontamination can reduce environmental contamination with and nosocomial transmission of Clostridium difficile. DESIGN:A prospective before-after intervention study. SETTING:A hospital affected by an epidemic strain of C. difficile. INTERVENTION:Intensiv...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/589906
更新日期:2008-08-01 00:00:00
abstract::OBJECTIVE The relationship between hospital antibiotic use and antibiotic resistance is poorly understood. We evaluated the association between antibiotic utilization and resistance in academic and community hospitals in Ontario, Canada. METHODS We conducted a multicenter observational ecological study of 37 hospitals...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1017/ice.2017.222
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To describe an outbreak of imipenem-resistant Acinetobacter baumannii (IR-Ab) and the measures for its control, and to investigate risk factors for IR-Ab acquisition. DESIGN:An observational and a case-control study. SETTING:A surgical intensive care unit (ICU) in a university tertiary care hospital. METHO...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/501822
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:In 2002, the Chicago Department of Public Health (CDPH; Chicago, Illinois) convened the Chicago-Area Neonatal MRSA Working Group (CANMWG) to discuss and compare approaches aimed at control of methicillin-resistant Staphylococcus aureus (MRSA) in neonatal intensive care units (NICUs). To better understand thes...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/501216
更新日期:2006-02-01 00:00:00
abstract::We propose the use of a machine learning algorithm to improve possible COVID-19 case identification more quickly using a mobile phone-based web survey. This method could reduce the spread of the virus in susceptible populations under quarantine. ...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2020.61
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:To quantify specific factors believed to increase healthcare worker (HCW) risk for contaminated sharps injuries (eg, visibility, communication, and range of motion); to quantify the degree to which respirators of various designs impacted those same factors; and to assess HCW opinions about the suitability of...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/647566
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To determine the attributable (direct) mortality and morbidity caused by carbapenem-resistant Klebsiella pneumoniae bacteremia. DESIGN:A matched retrospective, historical cohort design, using a stepwise procedure to stringently match the best control subjects to the best case subjects. SETTING:A 1,000-bed t...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/605922
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of changes to urine testing orderables in computerized physician order entry (CPOE) system on urine culturing practices. DESIGN:Retrospective before-and-after study. SETTING:A 1,250-bed academic tertiary-care referral center. PATIENTS:Hospitalized adults who had ≥1 urine culture perf...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2018.356
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To investigate and control an outbreak of colonization and infection caused by vancomycin-resistant enterococci (VRE) in a burn intensive care unit (BICU). DESIGN:Epidemiological investigation, including multiple point-prevalence culture surveys of patients and environment, cultures from hands of healthcare ...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/501806
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To assess the time-dependent exposure of California healthcare facilities to patients harboring methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae, and Clostridium difficile infec...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2015.181
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of 1-week ventilator circuit change on ventilator-associated pneumonia and its cost-effectiveness compared with a 2-day change. DESIGN:An observational cohort study. SETTING:A tertiary level neonatal intensive care unit in a university-affiliated teaching hospital in Taiwan. Patien...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2014.48
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To determine the impact of the introduction of a plastic shield-shaped device (Needleguard, Biosafe, Auckland, New Zealand) and education program designed to allow safer recapping, on recorded rates of needlestick injury. DESIGN:A before-after trial with a two-year duration of follow-up. SETTING:Tertiary re...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/646328
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVE:To compare the impacts of different methicillin-resistant Staphylococcus aureus (MRSA) screening test options (eg, polymerase chain reaction [PCR], rapid culture) and program characteristics on the clinical outcomes and budget of a typical US hospital. METHODS:We developed an Excel-based decision-analytic mo...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/658332
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Most nosocomial acquistion of vancomycin-resistant enterococci (VRE) is due to cross-transmission. We sought to identify risk factors for acquisition of VRE by roommates of patients colonized or infected with VRE. DESIGN:Retrospective cohort study. SETTING:A 472-bed tertiary care teaching hospital. METHODS...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/587187
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To report the International Nosocomial Infection Control Consortium surveillance data from 40 hospitals (20 cities) in India 2004-2013. METHODS:Surveillance using US National Healthcare Safety Network's criteria and definitions, and International Nosocomial Infection Control Consortium methodology. RESULTS:...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2015.276
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:Multidrug-resistant Enterobacteriaceae pose a serious infection control challenge and have emerged as a public health threat. We examined national trends in the proportion of Klebsiella pneumoniae isolates resistant to carbapenems (CRKP) and third-generation cephalosporins (G3CRKP). DESIGN AND SETTING:Retros...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/669523
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To investigate a possible nosocomial outbreak of tuberculosis (TB). DESIGN:Retrospective cohort study. SETTING:Community hospital. METHODS:We reviewed medical records, hospital infection control measures, and potential locations of nosocomial exposure. We examined the results of acid-fast bacilli (AFB) sme...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/502144
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To determine the safety and cost-effectiveness of replacing the intravenous (IV) tubing sets in hospitalized patients at 4- to 7-day intervals instead of every 72 hours. DESIGN:Prospective, randomized study of infusion-related contamination associated with changing IV tubing sets within 3 days versus within ...
journal_title:Infection control and hospital epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1086/501879
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Existing knowledge of emergency department (ED) catheter-associated urinary tract infection (CAUTI) prevention is limited. We aimed to describe the motivations, perceived risks for CAUTI acquisition, and strategies used to address CAUTI risk among EDs that had existing CAUTI prevention programs. METHODS:In ...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2015.267
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To develop and internally validate a surgical site infection (SSI) prediction model for Japan. DESIGN:Retrospective observational cohort study. METHODS:We analyzed surveillance data submitted to the Japan Nosocomial Infections Surveillance system for patients who had undergone target surgical procedures fro...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1017/ice.2015.302
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Reduce the frequency of contaminated blood cultures that meet National Healthcare Safety Network definitions for a central line-associated bloodstream infection (CLABSI). DESIGN:An observational study. SETTING:A 500-bed university-affiliated hospital. METHODS:A new blood culture policy discouraged drawing ...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/673142
更新日期:2013-10-01 00:00:00
abstract::Thorough counseling with emphasis on the importance of mosquito bite avoidance, as well as on compliance with prophylactic antimalarial regimens, remains an important task for the physician preparing a patient for international travel. Chloroquine continues to be the drug of choice for prophylaxis in areas not reporti...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章,评审
doi:10.1086/646703
更新日期:1993-03-01 00:00:00
abstract::Of 49 long-term care facility residents, 21 (43%) were colonized with 2 or more distinct strains of Escherichia coli. There were no significant risk factors for colonization with multiple strains of E. coli. These results suggest that future efforts to efficiently identify the diversity of colonizing strains will be c...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/597234
更新日期:2009-05-01 00:00:00
abstract::Glutaraldehyde (pentanedial) is a dialdehyde that displays potent bactericidal, fungicidal, mycobactericidal, sporicidal, and virucidal activity. Pertinent to its activity is its interaction with amino groups in proteins and enzymes, but this simplistic statement masks the manner in which it inactivates various types ...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章,评审
doi:10.1086/646845
更新日期:1994-11-01 00:00:00
abstract::BACKGROUND Healthcare provider hands are an important source of intraoperative bacterial transmission events associated with postoperative infection development. OBJECTIVE To explore the efficacy of a novel hand hygiene improvement system leveraging provider proximity and individual and group performance feedback in r...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1017/ice.2016.106
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To compare the sensitivity and specificity of two retrospective active surveillance methods based on review of the medical record and review of the discharge form in identfying nosocomial infection, taking the prospective surveillance method as the reference standard. DESIGN:Blind comparison of three active ...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/501692
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the influence of matching on exposure time on estimates of attributable mortality of nosocomial bacteremia as assessed by matched cohort studies. DESIGN:Two retrospective, pairwise-matched (1:2) cohort studies. SETTING:A 54-bed intensive care unit (ICU) in a university hospital. PATIENTS:Patien...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/502551
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the cost-effectiveness of a dual strategy of tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT-G) for screening of latent tuberculosis infection (LTBI) in healthcare workers (HCWs) and, as a secondary objective, to study relationships between TST results, QFT-G results, and sociodemographic ...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/668436
更新日期:2012-12-01 00:00:00
abstract::Antimicrobial agents used as disinfectants and antiseptics are increasing in epidemiologic importance. The regulation of topical antiseptics has ranged from nonexistent, lax and confusing to inclusion in the Food and Drug Administration (FDA) over-the-counter (OTC) review of drug ingredients. This article simplifies t...
journal_title:Infection control and hospital epidemiology
pub_type: 历史文章,杂志文章
doi:10.1086/645935
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between contact precautions and delirium among inpatients, adjusting for other factors. DESIGN:Retrospective cohort study. SETTING:A 662-bed tertiary care center. PATIENTS:All nonpyschiatric adult patients admitted to a tertiary care center from 2007 through 2009. METHODS:G...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/663340
更新日期:2012-01-01 00:00:00