Abstract:
OBJECTIVE:To evaluate the influence of matching on exposure time on estimates of attributable mortality of nosocomial bacteremia as assessed by matched cohort studies. DESIGN:Two retrospective, pairwise-matched (1:2) cohort studies. SETTING:A 54-bed intensive care unit (ICU) in a university hospital. PATIENTS:Patients with nosocomial Escherichia coli bacteremia (n = 68) and control-patients without nosocomial bacteremia (n = 136 for each matched cohort study). INTERVENTION:In both matched cohort studies, the same set of bacteremic patients was matched with control-patients using the APACHE II system. In the first study, control-patients were required to have an ICU stay at least as long as the respective bacteremic patient prior to onset of bacteremia (matching on exposure time). In the second study, control-patients were required to have an ICU stay shorter than the stay prior to the development of bacteremia in the respective bacteremic patient (no matching on exposure time). RESULTS:For bacteremic patients, the mean ICU stay before onset of the bacteremia was 9 days (median, 6 days). In the first matched cohort study, hospital mortality was not different between bacteremic patients and control-patients (44.1% vs 43.4%; P = .999). In the second study, mortality of bacteremic patients and control-patients was also not different (44.1% vs 47.8%; P = .657). Mortality rates between control groups were not different (43.4% vs 47.8%; P = .543). CONCLUSION:Matching or not matching on exposure time did not alter the estimate of attributable mortality for ICU patients with E. coli bacteremia.
journal_name
Infect Control Hosp Epidemioljournal_title
Infection control and hospital epidemiologyauthors
Blot S,De Bacquer D,Hoste E,Depuydt P,Vandewoude K,De Waele J,Benoit D,De Schuijmer J,Colardyn F,Vogelaers Ddoi
10.1086/502551subject
Has Abstractpub_date
2005-04-01 00:00:00pages
352-6issue
4eissn
0899-823Xissn
1559-6834pii
ICHE10232journal_volume
26pub_type
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journal_title:Infection control and hospital epidemiology
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journal_title:Infection control and hospital epidemiology
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journal_title:Infection control and hospital epidemiology
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更新日期:2008-12-01 00:00:00
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journal_title:Infection control and hospital epidemiology
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更新日期:1997-02-01 00:00:00
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journal_title:Infection control and hospital epidemiology
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更新日期:1997-04-01 00:00:00
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更新日期:2012-02-01 00:00:00
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-05-01 00:00:00
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更新日期:2010-12-01 00:00:00
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更新日期:2008-08-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:1995-01-01 00:00:00
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更新日期:2017-06-01 00:00:00
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更新日期:2010-01-01 00:00:00
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更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00