The high-affinity immunoglobulin E receptor (FcepsilonRI) regulates mitochondrial calcium uptake and a dihydropyridine receptor-mediated calcium influx in mast cells: Role of the FcepsilonRIbeta chain immunoreceptor tyrosine-based activation motif.

abstract：:A process of differentiation was observed when ob17 preadipocyte cells were stably transfected with a vector containing the cDNA of the human A1 adenosine receptor of adipose tissue. Growth of the cell lines continued but was slowed relative to untransfected cells and cells transfected with vector alone, never attaini...

journal_title：Biochemical pharmacology

authors： Tatsis-Kotsidis I,Erlanger BF

更新日期：1999-07-01 00:00:00

abstract：:The importance of polyglutamation for the activation of natural folates and classical antifolates and recent evidence for the role of dietary folate as a biochemical modulator of antifolate efficacy led us to investigate the influence of changes in dietary folate on folylpolyglutamate synthetase (FPGS) activity. Activ...

journal_title：Biochemical pharmacology

authors： Gates SB,Worzalla JF,Shih C,Grindey GB,Mendelsohn LG

更新日期：1996-11-08 00:00:00

abstract：:Extracellular ATP suppressed the growth of HL-60 leukemia cells and induced their differentiation as revealed by N-formyl-methionyl-leucyl-phenylalanine-induced beta-glucuronidase release. ATP degraded to ADP, AMP, and adenosine, and the effect of ATP on cell growth was mimicked by these metabolites added to the cultu...

journal_title：Biochemical pharmacology

authors： Conigrave AD,van der Weyden L,Holt L,Jiang L,Wilson P,Christopherson RI,Morris MB

更新日期：2000-12-01 00:00:00

abstract：:S-Nitrosothiols, a class of NO donors, demonstrate potential benefits for cardiovascular diseases. Drugs for such chronic diseases require long term administration preferentially through the oral route. However, the absorption of S-nitrosothiols by the intestine, which is the first limiting barrier for their vascular ...

journal_title：Biochemical pharmacology

authors： Bonetti J,Zhou Y,Parent M,Clarot I,Yu H,Fries-Raeth I,Leroy P,Lartaud I,Gaucher C

更新日期：2018-09-01 00:00:00

abstract：:Breast cancer is the most prevalent type of tumor and the second leading cause of death due to cancer among women. Although screening methods, diagnosis and therapeutic options have improved in the last decade, chemoresistance remains an important challenge. There is evidence relating breast cancer resistance with sig...

journal_title：Biochemical pharmacology

authors： Muley H,Fadó R,Rodríguez-Rodríguez R,Casals N

更新日期：2020-07-01 00:00:00

abstract：:"Are new neurons added in the adult mammalian brain?" "Do neural stem cells activate following CNS diseases?" "How can we modulate their activation to promote recovery?" Recent findings in the field provide novel insights for addressing these questions from a new perspective. In this review, we will summarize the curr...

journal_title：Biochemical pharmacology

authors： Pino A,Fumagalli G,Bifari F,Decimo I

更新日期：2017-10-01 00:00:00

abstract：:These studies were designed to investigate the effects of the chrysotherapeutic agents auranofin and myochrysine (GST) on hepatic and renal drug-metabolizing enzymes and heme metabolism. Male Sprague-Dawley rats were either administered a single dose of auranofin (17, 34, or 68 mg/kg, p.o.) or administered daily doses...

journal_title：Biochemical pharmacology

authors： Leonard TB,Graichen ME,Dahm LJ,Dent JG

更新日期：1986-09-15 00:00:00

abstract：:The PI3K/AKT/mTOR signaling pathway regulates cell proliferation, survival and angiogenesis. The mammalian target of rapamycin (mTOR) is a protein kinase ubiquitously expressed within cells that regulates cell growth and survival by integrating nutrient and hormonal signals. mTOR exists in two complexes, mTORC1 and mT...

journal_title：Biochemical pharmacology

authors： Espona-Fiedler M,Soto-Cerrato V,Hosseini A,Lizcano JM,Guallar V,Quesada R,Gao T,Pérez-Tomás R

更新日期：2012-02-15 00:00:00

abstract：:We have used 2-(beta-(3-125iodo-4-hydroxyphenyl)-ethylaminoethyl)-tetr alo ne ([125I]HEAT or BE2254), an alpha 1-selective antagonist, and [3H]yohimbine, an alpha 2-selective antagonist, to demonstrate and characterize binding sites in basolateral membranes from rat kidney cortex. Parathyroid hormone (PTH) stimulated ...

journal_title：Biochemical pharmacology

authors： Matsushima Y,Akabane S,Ito K

更新日期：1986-08-01 00:00:00

abstract：:The protein tyrosine kinase Src is expressed widely in the central nervous system and is abundant in neurons. Over the past several years, evidence has accumulated showing that one function of Src is to regulate the activity of N-methyl-D-aspartate (NMDA) receptors and other ion channels. NMDA receptors are a principa...

journal_title：Biochemical pharmacology

authors： Salter MW

更新日期：1998-10-01 00:00:00

abstract：:The carrier protein for methotrexate and tetrahydrofolate cofactors (GP-MTX) in CCRF-CEM human lymphoblastic leukemia cells in a 117 kDa glycoprotein containing both N- and O-linked oligosaccharides (Matherly et al., J Biol Chem 267: 23253-23260, 1992). Tunicamycin, an inhibitor of N-glycosylation, was used to investi...

journal_title：Biochemical pharmacology

authors： Matherly LH,Angeles SM

更新日期：1994-03-15 00:00:00

abstract：:The effect of the adenosine deaminase (ADA) inhibitor 2'-deoxycoformycin (dCF) on the development of insulin-dependent diabetes mellitus (IDDM) was assessed in the BB Wistar rat. Sixty-one male rats were treated from days 30 to 120 with 0, 0.5, 1.0 or 1.5 mg dCF/kg/week. The incidence of IDDM was 78% in the controls a...

journal_title：Biochemical pharmacology

authors： Thliveris JA,Begleiter A,Kobrinsky NL,Verburg L,Dean HJ,Johnston JB

更新日期：1993-09-14 00:00:00

abstract：:The enzyme S-adenosyl-homocysteine hydrolase (AdoHcyase) which catalyzes the reversible hydrolysis of AdoHcy to adenosine and homocysteine is an adenosine binding protein. In the present study we examined the characteristics of [(3)H]cAMP binding to purified AdoHcyase from bovine kidney in comparison with the high aff...

journal_title：Biochemical pharmacology

authors： Kloor D,Danielyan L,Osswald H

更新日期：2002-10-15 00:00:00

abstract：:The phenolic glucoside gastrodin, a main constituent of a Chinese traditional herbal medicine, has been known to display several biological and pharmacological properties. However, the role and precise molecular mechanisms explaining how gastrodin suppresses the inflammatory response in septic cardiac dysfunction are ...

journal_title：Biochemical pharmacology

authors： Yang P,Han Y,Gui L,Sun J,Chen YL,Song R,Guo JZ,Xie YN,Lu D,Sun L

更新日期：2013-04-15 00:00:00

abstract：:Guinea pig gallbladder muscle strips were used to investigate the contribution of different sources of diacylglicerol (DAG) in the cholecystokinin (CCK)-induced contraction. The involvement of arachidonic acid (AA) in this response was also investigated. Three distinct pathways for DAG production were investigated wit...

journal_title：Biochemical pharmacology

authors： Alcón S,Morales S,Camello PJ,Pozo MJ

更新日期：2002-10-01 00:00:00

abstract：:The effects of pretreatment with 3-methylcholanthrene (MC) and beta-naphthoflavone (beta NF) on the hepatic microsome-mediated mutagenesis of aflatoxin B1 (AFB1) and benzo[a]pyrene, and on the metabolism of aflatoxins B1 and B2, were investigated in inbred mouse strains. The inbred strains of mice studied included Ah ...

journal_title：Biochemical pharmacology

authors： Raina V,Williams CJ,Gurtoo HL

更新日期：1983-12-15 00:00:00

abstract：:The role of Na(+) and Na(+) exchangers in intracellular Ca(2+) elevation and leukotriene B(4) (LTBs) formation was investigated in granulocyte macrophage colony-stimulating factor (GM-CSF)-primed, fMLP-stimulated human neutrophils. Isotonic substitution of extracellular Na(+) with N-methyl-D-glucamine(+) (NMDG(+)) res...

journal_title：Biochemical pharmacology

authors： Tedeschi A,Ciceri P,Zarini S,Lorini M,Di Donato M,Nicosia S,Miadonna A,Sala A

更新日期：2004-01-15 00:00:00

abstract：:The influence of various concentrations of ferrous iron and ascorbate on in vitro peroxidation and drug binding of diverse membrane preparations (cerebral cortex and liver) was studied. Peroxidation was not simply dose-related to ascorbate and ferrous iron, but a complex relationship between iron and ascorbate when ad...

journal_title：Biochemical pharmacology

authors： Courtiere A,Molard F,Reybaud J

更新日期：1995-11-27 00:00:00

abstract：:Adipogenesis plays a central role in obesity development. The processes of adipogenesis include migration, adhesion, proliferation and survival of preadipocytes and differentiation to mature adipocytes. Many of these biological functions are related to integrins. Here, we found that snake venom-derived arginine-glycin...

journal_title：Biochemical pharmacology

authors： Lin YT,Tang CH,Chuang WJ,Wang SM,Huang TF,Fu WM

更新日期：2005-11-15 00:00:00

abstract：:Diclofenac is a non-steroidal anti-inflammatory drug that is widely used clinically but side effects associated with the administration of the drug have been reported. The apoptotic effect of the drug has been evaluated in human and rat hepatocytes. Apoptosis was observed after exposure to sub-cytotoxic concentrations...

journal_title：Biochemical pharmacology

authors： Gómez-Lechón MJ,Ponsoda X,O'Connor E,Donato T,Castell JV,Jover R

更新日期：2003-12-01 00:00:00

abstract：:Cells commonly resist growth inhibition by purine and pyrimidine bases and nucleosides by restricting intracellular formation of the corresponding 5'-mononucleotides. Nucleotide derivatives that can act as effective membrane-transport precursors of the poorly membrane-permeable nucleotides have not been identified so ...

journal_title：Biochemical pharmacology

authors： Freed JJ,Farquhar D,Hampton A

更新日期：1989-10-01 00:00:00

abstract：:Two antitumor antibiotics doxorubicin and daunorubicin were tested for their ability to influence the activation of protein kinase C in human platelets. Daunorubicin was found to inhibit the phosphorylation of the 40 K PKC substrate induced by thrombin and 12-O-tetradecanoyl-phorbol-13-acetate as well as the phosphory...

journal_title：Biochemical pharmacology

authors： Lanzi C,Banfi P,Ravagnani F,Gambetta RA

更新日期：1988-09-15 00:00:00

abstract：:We have investigated the ability of certain dietary flavonoids, known to exert beneficial effects on the central nervous system, to affect neuronal apoptosis. We used cerebellar granule cells undergoing apoptosis due to potassium deprivation in a serum-free medium in either the absence or presence of the flavonoids ge...

journal_title：Biochemical pharmacology

authors： Atlante A,Bobba A,Paventi G,Pizzuto R,Passarella S

更新日期：2010-03-01 00:00:00

abstract：:The in vivo actions of two antimetabolites, acivicin (NSC-163501) and tiazofurin (NSC-286193), were examined on the enzymic programs of rat bone marrow. From the bone marrow of the femurs, 100,000 g supernatant fractions were prepared; enzymic activities were measured by isotopic assays, and cellularity was determined...

journal_title：Biochemical pharmacology

authors： Prajda N,Natsumeda Y,Ikegami T,Reardon MA,Szondy S,Hashimoto Y,Emrani J,Weber G

更新日期：1988-03-01 00:00:00

abstract：:The effects of chronic lead exposure on mRNA expression, ADP-ribosylation and photoaffinity labeling with [alpha-32P]guanine triphosphate-gamma-azidoanilide ([32P]GTP-A) of alpha i or alpha s subunit of G protein were investigated in neurons isolated from the brain of neonatal and adult rats exposed to lead acetate or...

journal_title：Biochemical pharmacology

authors： Singh AK

更新日期：1993-03-09 00:00:00

abstract：:The effects of propranolol or phentolamine on the metabolism of phospholipids, diacylglycerol, and triacylglycerol were studied in the bovine retina in vitro. Lipid labeling was followed during short-term incubation of intact bovine retinas with [U-14C]glycerol and [1-14C]palmitic acid. Each of these precursors was re...

journal_title：Biochemical pharmacology

authors： de Boschero MG,Bazan NG

更新日期：1982-03-15 00:00:00

abstract：:This study was designed to examine the relationship between the extent of Sandimmun (cyclosporin A, SIM) metabolism and SIM-induced hepatotoxicity both in vivo and in primary cultures of rat hepatocytes. Firstly, SIM (50 mg/kg p.o.) was administered daily to male Wistar rats for 10 days with or without co-administrati...

journal_title：Biochemical pharmacology

authors： Bouis P,Brouillard JF,Fischer V,Donatsch P,Boelsterli UA

更新日期：1990-01-15 00:00:00

abstract：:Imidazoline-like drugs are centrally-acting antihypertensive agents that inhibit the activity of the sympathetic nervous system by interacting with the alpha2-adrenoreceptor and also with a non-adrenergic imidazoline binding site called the imidazoline 1 receptor. Recently, these molecules were proposed to play an add...

journal_title：Biochemical pharmacology

authors： Venteclef N,Guillard R,Issandou M

更新日期：2005-04-01 00:00:00

abstract：:Previously we reported that liposomal cisplatin (CDDP) overcomes CDDP resistance of ovarian A2780cis cancer cells (Krieger et al., Int. J. Pharm. 389, 2010, 10-17). Here we find that the cytotoxic activity of liposomal CDDP is not associated with detectable DNA platination in resistant ovarian cancer cells. This sugge...

journal_title：Biochemical pharmacology

authors： Koch M,Krieger ML,Stölting D,Brenner N,Beier M,Jaehde U,Wiese M,Royer HD,Bendas G

更新日期：2013-04-15 00:00:00

abstract：:Recent experiments from our laboratory have indicated that the inhibitory effect of 3'-azido-3'-deoxythymidine (AZT) on oxidative phosphorylation may occur directly, in addition to being brought about by its inhibition of mtDNA replication. We report here studies on the effect of AZT on adenylate kinase, an enzyme cru...

journal_title：Biochemical pharmacology

authors： Barile M,Valenti D,Hobbs GA,Abruzzese MF,Keilbaugh SA,Passarella S,Quagliariello E,Simpson MV

更新日期：1994-10-07 00:00:00