Abstract:
:The congenital absence of teeth is one of the commonest developmental abnormalities seen in human populations. Familial hypodontia or oligodontia represents an absence of varying numbers of primary and/or secondary teeth as an isolated trait. While much progress has been made in understanding the developmental basis of tooth formation, knowledge of the aetiological basis of inherited tooth loss remains poor. The study of mouse genetics has uncovered a large number of candidate genes for this condition, but mutations in only three have been identified in human pedigrees with familial hypodontia or oligodontia: MSX1, PAX9 and AXIN2. This suggests that these conditions may represent a more complex multifactorial trait, influenced by a combination of gene function, environmental interaction and developmental timing. Completion of the human genome project has made available the DNA sequence of the collected human chromosomes, allowing the localisation of all human genes and, ultimately, determination of their function. Therefore it is likely that our understanding of this complex developmental process will continue to improve, not only during normal development but also when things go wrong.
journal_name
Br Dent Jjournal_title
British dental journalauthors
Cobourne MTdoi
10.1038/bdj.2007.732subject
Has Abstractpub_date
2007-08-25 00:00:00pages
203-8issue
4eissn
0007-0610issn
1476-5373pii
bdj.2007.732journal_volume
203pub_type
杂志文章,评审abstract::This article forms part of a BDJ series of Practice papers on the subject of clinical examination and related record keeping. The series is taken from the Faculty of General Dental Practice UK (FGDP[UK]) 2016 Good Practice Guidelines book on this topic, edited by A. M. Hadden. This particular article, the first in the...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2017.984
更新日期:2017-11-24 00:00:00
abstract::This is the first of two articles that provide a guide for the clinical management for people with dementia who present with periodontal disease in dental practice. Conditions that cause dementia and their increasing prevalence are described. Advice is given to aid the dental team in recognising patients with dementia...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/s41415-019-0726-4
更新日期:2019-10-01 00:00:00
abstract::The incidence of head and neck cancer is on the rise. Most head and neck cancers are treated with surgery, radiotherapy, chemotherapy or a combination of these modalities. Patients undergoing radiotherapy can experience several unwanted oral side effects, which have both short and long term implications. Dental genera...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.2015.28
更新日期:2015-01-01 00:00:00
abstract:AIM:The aim of this study was to measure organ doses and calculate the effective dose for indirect and direct digital cephalometric exposures. MATERIAL AND METHODS:Indirect digital cephalometric exposures were made of a Rando phantom head using a Cranex Tome multipurpose unit with storage phosphor plates from Agfa and...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4811532
更新日期:2004-08-14 00:00:00
abstract::Non-Hodgkin's lymphoma (NHL) of the oral cavity frequently occurs in patients infected with human immunodeficiency virus (HIV). This report describes a lesion presenting as delayed healing of an extraction wound with hyperaemic swollen gingivae and ulceration in an apparently healthy 34-year-old Thai fisherman. The le...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809172
更新日期:1996-08-10 00:00:00
abstract:PURPOSE:To report the results at year one of a three-year evaluation of the performance of fixed all-ceramic bridges, constructed with a yttrium tetragonal zirconia polycrystal substructure placed in adult patients in UK general dental practices and cemented using a self-adhesive resin-based cement. METHODS:Ethical ap...
journal_title:British dental journal
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.bdj.2008.937
更新日期:2008-11-08 00:00:00
abstract::The issue of standards of competence and assessment is central to professions. For the dental profession there have been suggestions that a change from overall competence to specific fields of competence would be a more suitable mechanism to assess whether an individual was competent. This paper examines the implicati...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809751
更新日期:1998-08-08 00:00:00
abstract::These extracts from the literary archive focus on the role of teeth as a facial feature. Their contribution to favourable and unfavourable facial appearance by their presence or absence, their use as a guide to character and as a means of identification are illustrated. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4801207
更新日期:2001-10-27 00:00:00
abstract::This paper describes the three successive and successful DentEd projects, funded by the European Union, that established a productive thematic network which identified common content within the dental curriculum. It then developed an agreed professional profile, with a defined set of competences and a modular curricul...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2008.698
更新日期:2008-08-23 00:00:00
abstract::Oral histoplasmosis, a rare condition, is reported in two HIV-infected patients. The lesions showed different characteristics. One was an ulcerative lesion presenting as the only manifestation of the disease. The other was nodular, with disseminated histoplasmosis. In both cases infection with Candida was also noted w...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809373
更新日期:1997-04-26 00:00:00
abstract:OBJECTIVES:To undertake a clinical trial comparing the efficiency of a compomer restoration with a glass ionomer restoration in the management of caries in primary molar teeth. DESIGN:Subjects were admitted to the trial if they required at least one pair of restorations in primary molar teeth. SETTING:Department of C...
journal_title:British dental journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.bdj.4800693
更新日期:2000-07-22 00:00:00
abstract:OBJECTIVES:To evaluate experience, practice and beliefs regarding occupational exposures to blood and oral fluids among a random sample of 300 dentists working in Scotland's NHS primary dental services. METHOD:A cross-sectional postal survey assessed occupational exposure policies and procedures, recent occupational e...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2014.734
更新日期:2014-08-01 00:00:00
abstract::Introduction This study was conducted in light of the SARS-CoV-2 pandemic, which brought UK dentistry to a standstill. The market has seen a recent influx of unproven extraoral scavengers (EOSs), which claim to reduce the risk of particulate spread.Aims To investigate the efficacy of a commercially available EOS devic...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/s41415-020-2112-7
更新日期:2020-09-11 00:00:00
abstract:OBJECTIVE:To review the use of calcium hydroxide for induction of apical barrier formation and healing in immature permanent teeth. INTRODUCTION:Pulp necrosis is a frequent complication of dental trauma in immature permanent teeth. Endodontic treatment of these teeth is often complicated. The walls of the root canals ...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.4809477
更新日期:1997-10-11 00:00:00
abstract::Dental health education is an important part of our professional activities given we provide day-to-day treatment of caries and periodontal disease which can mostly be controlled by our patients, provided they implement relatively simple changes in their daily oral health habits. However, efforts in the field of both ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809544
更新日期:1998-01-24 00:00:00
abstract::North London may seem an unlikely venue for a discussion about orthodontics which takes us as far afield as South Africa and the USA, but Edgware is where I find the head office of OrthoWorld. At the time of writing OrthoWorld are the only specialist body corporate in the UK. I am meeting Dr. Morris Fine, Director of ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4801630
更新日期:2002-11-23 00:00:00
abstract::Tongue piercing remains popular. A variety of complications have been reported, including life-threatening infection, airway problems and damaged teeth or mucosal surfaces. A patient who collapsed after continuous profuse bleeding following tongue piercing is presented. It is recommended that piercing practitioners be...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4800568
更新日期:2000-06-24 00:00:00
abstract::Having listened to, examined, tested, diagnosed and recommended a course of action to the patient, treatment will usually follow at the same or subsequent visits. In the vast majority of cases, the foregoing will have proceeded without a hitch, and the treatment completed to the satisfaction of both the practitioner a...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4806759
更新日期:1989-03-11 00:00:00
abstract::Introduction Shared decision-making (SDM) is a process by which patients and clinicians work collaboratively to make decisions about healthcare. Previously, research has shown that patients want to be more involved in decisions about their care, but more recent evidence suggests that some patients may not wish to have...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/s41415-020-1638-z
更新日期:2020-06-01 00:00:00
abstract::Correctly managing interdental papillae is a key step in producing satisfactory, interproximal, direct composite restorations. This article discusses techniques to facilitate the restoration of sub-gingival cavities and suggests a decision-making workflow that can be applied in this challenging situation. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/s41415-019-0412-6
更新日期:2019-06-01 00:00:00
abstract::This article demonstrates the benefits of collaboration between dental educators in undergraduate and postgraduate settings, to facilitate the transition of dental students into dental foundation training (DFT). The School of Dental Sciences at Newcastle University and Health Education England, working across north-ea...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2018.79
更新日期:2018-02-23 00:00:00
abstract::Are dental students well-equipped to deal with difficult communication situations? ...
journal_title:British dental journal
pub_type: 评论,杂志文章
doi:10.1038/sj.bdj.2018.101
更新日期:2018-02-09 00:00:00
abstract:AIM:To identify potential problems in the quality of care when oral surgery is provided in the primary health care setting. METHOD:Retrospective analysis of referral patterns, waiting times, treatment with clinical and histological diagnosis, including complications of 600 patients referred to a practice-based oral su...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2007.571
更新日期:2007-08-11 00:00:00
abstract::Of note, the symptom load was still high five years after removal of the amalgam restorations. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2017.450
更新日期:2017-05-26 00:00:00
abstract::The use of problem-based learning as part of a vocational training scheme for vocational dental practitioners is described and evaluated. Problem-based learning is currently viewed as an effective means of delivering medical education and has been adopted as a principal style of education by many undergraduate medical...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4800213
更新日期:1999-07-24 00:00:00
abstract:Introduction:This paper defines key points from a ten million restoration dataset in order to compare and contrast the data from the previous nine papers, identifying common themes and/or differences in the factors affecting the survival of restored teeth to next intervention or extraction. Aim:It is the aim of this p...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2018.1029
更新日期:2018-12-14 00:00:00
abstract::There is evidence, although limited, for beneficial effects of bisphophonates (BPs) across multiple dental specialties. Within implant dentistry BP coatings have been shown to significantly increase pull out forces and bone density in animal models, and significantly increase implant stability whilst reducing marginal...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.2017.412
更新日期:2017-05-12 00:00:00
abstract::April 1993 saw the introduction of the 'Community Care' element of the 1990 NHS and Community Care Act. The term 'Community Care' describes the relocation of long-stay hospital residents to community accommodation. Much public attention has recently been focused on the welfare of psychiatric patients in the community,...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808358
更新日期:1994-01-22 00:00:00
abstract::Aim To compare trends in the volume, socio-demography and academic experience of UK applicants and entrants to medicine and dentistry in the UK with university in general, before and after the major increase in university fees in England in 2012.Methods Descriptive trend analyses of University and College Admissions S...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2017.122
更新日期:2017-02-10 00:00:00
abstract:OBJECTIVES:To investigate the composition of black tea in terms of its erosive potential. To determine the pH profile at the palatal surface of anterior and posterior sites of the dentition after drinking black tea. METHODS:Tea solution was analysed for its pH and anion composition to provide information on its acid c...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4800977
更新日期:2001-04-14 00:00:00