Abstract:
:We have recently characterized the transcriptome of the omental adipose tissue of non-diabetic, obese men with and without the metabolic syndrome (MS). The cysteine-rich protein 61 (CYR61) is one of the most differentially expressed genes between the groups and has been selected for a detailed molecular investigation. Direct sequencing of complete CYR61 gene revealed five polymorphisms with minor allele frequency >5% in the promoter region (rs 3753794, rs 3753793 and rs 2297140), intron 1 (rs 2297141) and intron 2 (IVS 2+50). Chi-square test and logistic regression were applied to test for association between CYR61 polymorphisms and the individual MS components in a cohort of 697 obese individuals. In men and women, rs 3753794 and rs 3753793 (r2 = 0.77) were associated plasma HDL-cholesterol levels (p = 0.016 and p = 0.008). Carriers of the A allele for rs 3753794 were more likely to have high plasma HDL-cholesterol levels (1.50-fold; p = 0.016), as compared with G/G homozygotes and the A/A homozygotes for rs 3753793 were more likely to exhibit low plasma HDL-cholesterol levels (1.56-fold; p = 0.008), as compared with C/C homozygotes. Furthermore, an association between IVS 2+50 polymorphism and HDL-cholesterol was found in women and in men analyzed separately (p = 0.002 and p = 0.038, respectively). These results suggest that CYR61 is a promising candidate gene for lipoprotein/lipid perturbations.
journal_name
Clin Genetjournal_title
Clinical geneticsauthors
Bouchard L,Tchernof A,Deshaies Y,Lebel S,Hould FS,Marceau P,Vohl MCdoi
10.1111/j.1399-0004.2007.00855.xsubject
Has Abstractpub_date
2007-09-01 00:00:00pages
224-9issue
3eissn
0009-9163issn
1399-0004pii
CGE855journal_volume
72pub_type
杂志文章abstract::The potential causes for the incomplete penetrance of Pelizaeus-Merzbacher disease (PMD) in female carriers of PLP1 mutations are not well understood. We present a family with a boy having PMD in association with PLP1 duplication and three females who are apparent manifesting carriers. Custom high-resolution oligonucl...
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doi:10.1111/j.1399-0004.1990.tb03483.x
更新日期:1990-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1034/j.1399-0004.2000.580601.x
更新日期:2000-12-01 00:00:00
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更新日期:1976-02-01 00:00:00
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doi:10.1111/j.1399-0004.2011.01765.x
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doi:10.1111/j.1399-0004.1993.tb03889.x
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doi:10.1111/j.1399-0004.1994.tb03996.x
更新日期:1994-02-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
doi:10.1111/j.1399-0004.1986.tb00609.x
更新日期:1986-10-01 00:00:00
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