Abstract：
:Basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (SCCs) are the most common malignancies in humans. Together, they constitute approximately 95% of nonmelanoma skin cancers (NMSCs). Surgical excision remains the mainstay of therapy of low-risk NMSC, though Mohs micrographic surgery is the gold standard for high-risk NMSC. Both methods produce high cure rates, but they may not be appropriate treatments for elderly patients who are either not surgical candidates or refuse to undergo surgery for their skin cancers. Imiquimod cream 5% is a topical immune response modifier that targets the toll-like receptors 7 and 8 and up-regulates inflammatory pathways targeting diseased tissue. This noninvasive topical therapy may be more appropriate for some patients. Herein, we describe our 5-month clinical experience in mostly elderly subjects with BCC (n=21) or SCC (n= 19) who were not candidates for surgical excision and were treated with topical imiquimod. Most subjects had a history of skin cancer, and the median age of the subjects was 78 years and 79 years in the BCC and SCC groups, respectively. After biopsy alone or biopsy followed by curettage, subjects received imiquimod cream 5% once daily 5 times weekly for 6 weeks. Twenty-three BCC lesions and 22 SCC lesions were included in the analysis. Most of the 45 lesions treated were located on the head and most were in high-risk areas. Approximately 3 months after imiquimod therapy, repeat biopsies showed that only 3 (2 BCCs and 1 SCC) lesion sites had residual tumor. After a median follow-up of 26 months, there was only one additional SCC recurrence. We also present a selection of representative case studies. Imiquimod cream 5% as adjunctive therapy to curettage was safe and well-tolerated in this mostly elderly population. The improved residual tumor and recurrence rates compared with historical rates for electrodesiccation and curettage (ED&C) alone suggest that adjunctive imiquimod therapy may be an appropriate treatment option for patients who desire or require less invasive treatment for NMSCs.
journal_name
Cutisjournal_title
Cutisauthors
Tillman DK Jr,Carroll MTsubject
Has Abstractpub_date
2007-03-01 00:00:00pages
241-8issue
3eissn
0011-4162issn
2326-6929journal_volume
79pub_type
杂志文章相关文献
CUTIS文献大全abstract：:Identifying the etiology of a cutaneous eruption in the setting of an acute cluster outbreak is of utmost importance due to the inherent potential public health impact. The differential diagnosis ranges from innocuous arthropod bites to more concerning causes such as infection, medication reaction, and environmental e...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：:Panniculitis occurred in a 34-year-old man. The clinical features of the panniculitis were not consistent with erythema nodosum, Weber-Christian disease, or the other previously described panniculitides. Subsequent investigation showed concurrent hepatitis possibly caused by type A hepatitis virus. The skin lesions re...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
abstract：:Scurvy is a well-known disease of vitamin C deficiency that still occurs in industrialized countries. The clinical manifestations of follicular hyperkeratosis, perifollicular petechiae, corkscrew hairs, and easy bruising are due to defective collagen synthesis and can be mistaken for small vessel vasculitis. Populatio...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
abstract：:The scar resulting from elective cutaneous surgery can be minimized if the location of the incision is chosen after considering the direction of the skin tension lines, creases, and wrinkles, and if the patient is positioned so that the skin of the surgical field is in a relaxed or anatomically neutral position. Selec...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1976-11-01 00:00:00
abstract：:A case of cutaneous hypopigmented macules localized above deep dermal and subcutaneous sarcoid granulomas in a patient with systemic sarcoidosis is presented. Melanin was only sparsely distributed in the upper stratum malpighii. Hypopigmentation is an unusual manifestation of sarcoidosis. With an armamentarium of clin...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Human dirofilariasis is a rare zoonotic infection caused by various filarial species of the genus Dirofilaria. Dirofilaria tenuis causes heartworm infection in raccoons and infrequently causes human disease. The Dirofilaria organism accidentally is transmitted to humans through the bite of a mosquito and subcutaneous ...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：:Cutaneous fungal infections in immunocompromised patients can be aggressive and difficult to treat. To determine the safety and efficacy of oral terbinafine for the treatment of tinea corporis or tinea cruris in subjects with human immunodeficiency virus (HIV) infection or diabetes, 2 prospective, randomized, open-lab...
journal_title：Cutis
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2001-07-01 00:00:00
abstract：:A case report of a young girl with nevoid basal cell carcinoma syndrome is presented. The patient showed cutaneous and skeletal findings characteristic of the syndrome. Multiple basal cell carcinomas, rib abnormalities, along with clinical evidence of frontal bossing and ocular hypertelorism were the primary features ...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
abstract：:Phytophotodermatitis is a phototoxic dermatitis resulting from contact with psoralen-containing plants such as celery, limes, parsley, figs, and carrots. Berloque dermatitis is a variant of phytophotodermatitis and is caused by high concentrations of psoralen-containing fragrances, most commonly oil of bergamot. Berlo...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:Dermatopathologists have noted an increased number of smaller biopsy specimens. Our objective was to determine whether dermatologists are changing their choice of biopsy technique and the size of biopsy specimens. We conducted a retrospective study of 500 biopsies performed by dermatologists for the purpose of diagnos...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：:We report the case of a 6-year-old girl with a nevus comedonicus involving the left perineal region and ipsilateral labium majus. This lesion constitutes a rare hamartomatous malformation of the pilosebaceous apparatus, most frequently located on the face or trunk. Genital involvement has only very rarely been reporte...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:Investigators conducted two double-blind, randomized, parallel-group trials to compare the efficacy of fluticasone propionate cream, 0.05%, and betamethasone valerate cream, 0.1%, in the treatment of moderate-to-severe psoriasis. Up to 100 gm/week of the study medication was applied topically to affected areas of the ...
journal_title：Cutis
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-02-01 00:00:00
abstract：:The value of in vivo reflectance confocal microscopy (RCM) as a noninvasive adjunctive tool in dermatology has steadily advanced since its inception. With RCM, dermatologists can view horizontal sections of lesions in a resolution comparable to histology, observe dynamic processes in living skin, and monitor lesion ev...
journal_title：Cutis
pub_type： 杂志文章,评审
doi：
更新日期：2015-05-01 00:00:00
abstract：:Hand eczema is a common condition in the industrialized world and the most common occupational skin disorder. The economic impact of hand eczema is daunting, with both direct and indirect costs. The former include medical costs, as well as costs associated with disability, workers' compensation, and rehabilitation, wh...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：:As more individuals choose to maintain their fitness level year-round, they inevitably encounter skin problems. During these athletic pursuits, the skin must endure ongoing insult, serving as the interface between the athlete and environmental factors unique to the sport and season. Therefore, primary care physicians ...
journal_title：Cutis
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
abstract：:An association between pemphigus erythematosus and systemic lupus erythematosus is well recognized. However, most reports strongly imply that the clinical manifestations of lupus erythematosus are usually minimal or only serologically significant. We describe the case of a 27-year-old black woman who experienced life-...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
abstract：:Soft tissue calcification has been reported following the intramuscular injection of calcium salts and the intravenous administration of calcium gluconate. The present case report describes a neonate in whom calcification of the superficial scalp veins developed following administration of calcium chloride and sodium ...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
abstract：:Anthrax, caused by the spore-forming bacterium Bacillus anthracis, is rarely seen in industrial nations but is common in developing countries. Cutaneous anthrax (CA), the most common form of the disease, accounts for 95% of cases and usually develops on exposed sites. This study reviews the clinical and laboratory fin...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：:A four-year-old girl in whom severe, acute contact dermatitis of the face developed following a face painting party is presented herein. Subsequent investigation established that the paints consisted of tempera pigments mixed in a full-strength commercial dishwashing liquid. Similar contact dermatitis developed in at ...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1980-12-01 00:00:00
abstract：:Elephantiasis nostras is characterized by edema, skin fibrosis, and massive enlargement of a body part. Lymphatic obstruction, most commonly due to surgery, radiation, infection, or neoplasms, is important in its pathogenesis. The diagnosis of elephantiasis nostras can often be made based on the clinical findings, but...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:Since most clinicians and researchers agree that stress affects the course of psoriasis, consideration should be given to advocating adjunctive therapies aimed at reducing psychophysiological stress. Biofeedback training, psychotherapy, and hypnosis are examples of adjuncts to traditional medical treatment that can re...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:We present the case of a 25-year-old man who presented with a slowly enlarging nodule on the upper lip. This nodule first appeared after minor trauma to the area. Our original differential diagnosis included foreign body granuloma, mucocele, inclusion cyst, and adnexal tumor. Histopathology results showed an encapsula...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Worldwide, there are more than 3250 deaths a year related to scorpion stings. With the increasing popularity of exotic and dangerous pets, American physicians are more likely to see exotic scorpion envenomations. Although adults are stung more often, children experience more severe envenomation. ...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2019-10-01 00:00:00
abstract：:Pancreatic panniculitis represents a rare skin manifestation of underlying pancreatic pathology. The clinical presentation of the condition is remarkably consistent and privy to several unique clinical and histopathologic findings. We report a case of a 50-year-old white woman with pancreatic panniculitis and newly di...
journal_title：Cutis
pub_type： 杂志文章,评审
doi：
更新日期：2007-10-01 00:00:00
abstract：:Meningiomas generally present as slow-growing, expanding intracranial lesions and are the most common benign intracranial tumor in adults. Rarely, meningiomas can exhibit malignant potential and present as extracranial soft-tissue masses through extension or as primary extracranial cutaneous neoplasms. Although they a...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2018-05-01 00:00:00
abstract：:A typical case of eosinophilic ulcer of the tongue is described. It confirms the traumatic cause for this benign, self-healing lesion that may be misdiagnosed and clinically confused with squamous cell carcinoma. The short time that the lesion takes to heal is an important diagnostic clue in differentiating eosinophil...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:Bathing trunks nevi, a subtype of giant congenital melanocytic nevi (CMN), are skin tumors that present by 2 years of age and occur in a low percentage of all births. We report a case of bathing trunks nevus that was initially suspected to be melanoma, and describe the history, pathophysiology, and treatment options f...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
abstract：:Psoriasis is a genetically programmed pathologic interaction among skin cells, immunocytes, and numerous biologic signaling molecules that is triggered by environmental stimuli. The immune response is a cellular one; type 1 (TH1) and type 17 (TH17) T cells are activated by IL-12 and IL-23 secreted by antigen-presentin...
journal_title：Cutis
pub_type： 杂志文章,评审
doi：
更新日期：2018-11-01 00:00:00
abstract：:Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis with unclear etiology and is associated with notable morbidity. Due to the rarity of PG, there are limited large, multicentered, randomized trials to guide management. We aim to highlight best practices in PG management through survey responses from expert me...
journal_title：Cutis
pub_type： 杂志文章
doi：10.12788/cutis.0076
更新日期：2020-09-01 00:00:00
abstract：:Many dermatologic diseases, including vitiligo and other pigmentary disorders, vascular malformations, acne, and disfiguring scars from surgery or trauma, can be distressing to pediatric patients and can cause psychological alterations such as depression, loss of self-esteem, deterioration of quality of life, emotiona...
journal_title：Cutis
pub_type： 杂志文章
doi：
更新日期：2007-02-01 00:00:00
