Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells.

abstract：:The occurrence of potential leukemia cells (PLC) among bone marrow, spleen, and thymus of AKR mice during the preleukemic period was tested by an in vivo transplantation bioassay. The presence of PLC in 30- and 75-day-old AKR mice was demonstrated mostly among bone marrow cells, less in spleen, and was lacking in thym...

journal_title：Leukemia

authors： Haran-Ghera N,Peled A,Leef F,Hoffman AD,Levy JA

更新日期：1987-05-01 00:00:00

abstract：:Ninety-five percent of radiation-induced murine myeloid leukemias contain chromosome 2 aberrations. A dominant molecular defect has not yet been identified: both deletions and breakpoint-specific events have been postulated. We have generated a model in which chromosome 2 lesions have been generated in vitro in a clon...

journal_title：Leukemia

authors： Alexander BJ,Rasko JE,Morahan G,Cook WD

更新日期：1995-12-01 00:00:00

abstract：:We reported HTLV-1 uveitis (HU) as the third distinct clinical entity associated with HTLV-1 infection. Uveitis has advantages for studying the pathogenetic mechanisms of inflammatory diseases caused by HTLV-1, since observation of the disease process is relatively easy and clinical samples from the lesion can be obta...

journal_title：Leukemia

authors： Watanabe T,Mochizuki M,Yamaguchi K

更新日期：1997-04-01 00:00:00

abstract：:Viral infection induces potent cellular immunity and activated intracellular signaling, which may dictate the driver events involved in immune escape and clonal selection of virus-associated cancers, including Epstein-Barr virus (EBV)-positive lymphomas. Here, we thoroughly interrogated PD-L1/PD-L2-involving somatic a...

journal_title：Leukemia

authors： Kataoka K,Miyoshi H,Sakata S,Dobashi A,Couronné L,Kogure Y,Sato Y,Nishida K,Gion Y,Shiraishi Y,Tanaka H,Chiba K,Watatani Y,Kakiuchi N,Shiozawa Y,Yoshizato T,Yoshida K,Makishima H,Sanada M,Onozawa M,Teshima T,Yos

更新日期：2019-07-01 00:00:00

abstract：:Upregulation of the immunosuppressive cell surface glycoprotein, CD200, is a common feature of acute myeloid leukemia (AML) and is associated with poor patient outcome. We investigated whether CD200 overexpression on AML cells could specifically compromise patient natural killer (NK) cell anti-tumor responses. We foun...

journal_title：Leukemia

authors： Coles SJ,Wang EC,Man S,Hills RK,Burnett AK,Tonks A,Darley RL

更新日期：2011-05-01 00:00:00

abstract：:Fresh and/or frozen bone marrow cells from five healthy individuals and seven patients with myeloid leukemia were studied using growth factors and a cytogenetic technique which allows simultaneous analysis of karotype and cell lineage. Cell lineages were identified using monoclonal antibodies in an alkaline phosphatas...

journal_title：Leukemia

authors： Keinänen M,Bloomfield CD,Machnicki J,Griffin JD,de la Chapelle A

更新日期：1989-06-01 00:00:00

abstract：:This report documents the follow-up information on 69 hairy cell leukemia (HCL) patients treated with interferon alpha-2b (IFN) as primary treatment from 1983-86. Follow-up through October 1991 shows only 11 patients have died. Forty-one of the 57 patients completing the intended 12 or more months of initial IFN treat...

journal_title：Leukemia

authors： Golomb HM,Ratain MJ,Mick R,Daly K

更新日期：1992-11-01 00:00:00

abstract：:The current study was undertaken to search for differences in the biology of cytogenetic subgroups in patients with de novo acute myeloid leukemia (AML). In addition, factors influencing the metabolism of cytosine arabinoside (araC) as the key agent of antileukemic activity were assessed. Bone marrow aspirates from 91...

journal_title：Leukemia

authors： Jahns-Streubel G,Braess J,Schoch C,Fonatsch C,Haase D,Binder C,Wörmann B,Büchner T,Hiddemann W

更新日期：2001-03-01 00:00:00

abstract：:Until 1990, the survival of children with acute lymphoblastic leukaemia (ALL) in Russia was below 10%. To establish a protocol feasible under conditions there, ALL-MB 91 was designed to avoid prolonged bone marrow aplasia, thereby reducing needs for extensive supportive care, blood transfusions, long-lasting hospitali...

journal_title：Leukemia

authors： Karachunskiy A,Herold R,von Stackelberg A,Miakova N,Timakow A,Mahortih T,Bajdun L,Maschan A,Fechina L,Shamardina A,Dudkin S,Lebedev V,Varfolomeeva S,Timofeeva V,Roumiantseva J,Chipsanova N,Rumjanzew A,Henze G

更新日期：2008-06-01 00:00:00

abstract：:Only two classes of chemotherapeutic agents have shown activity in acute myeloid leukemia (AML): ara-C and topoisomerase II reactive agents. Frontline combinations of these agents produce complete response (CR) rates of 70% and long-term event free survival rates of 25%. New agents with different mechanisms of action ...

journal_title：Leukemia

authors： Kantarjian HM,Estey EH,Keating MA

更新日期：1996-04-01 00:00:00

abstract：:Genomic analyses of chronic lymphocytic leukemia (CLL) identified somatic mutations and associations of clonal diversity with adverse outcomes. Clonal evolution likely has therapeutic implications but its dynamic is less well studied. We studied clonal composition and prognostic value of seven recurrently mutated driv...

journal_title：Leukemia

authors： Leeksma AC,Taylor J,Wu B,Gardner JR,He J,Nahas M,Gonen M,Alemayehu WG,Te Raa D,Walther T,Hüllein J,Dietrich S,Claus R,de Boer F,de Heer K,Dubois J,Dampmann M,Dürig J,van Oers MHJ,Geisler CH,Eldering E,Levine RL

更新日期：2019-02-01 00:00:00

abstract：:Targeting of B cell receptor associated kinases (BAKs), such as Bruton's tyrosine kinase (BTK) or phosphoinositol-3-kinase (PI3K) delta, by specific inhibitors has revolutionized the therapy of B lymphoid malignancies. BAKs are critical signaling transducers of BCR signaling and seem relevant in B cell lymphoma pathog...

journal_title：Leukemia

authors： Nguyen PH,Niesen E,Hallek M

更新日期：2019-03-01 00:00:00

abstract：:Here we describe the results of an interlaboratory test for RT-PCR-based BCR/ABL analysis. The test was organized in two parts. The number of participating laboratories in the first and second part was 27 and 20, respectively. In the first part samples containing various concentrations of plasmids with the ela2, b2a2 ...

journal_title：Leukemia

authors： Burmeister T,Maurer J,Aivado M,Elmaagacli AH,Grünebach F,Held KR,Hess G,Hochhaus A,Höppner W,Lentes KU,Lübbert M,Schäfer KL,Schafhausen P,Schmidt CA,Schüler F,Seeger K,Seelig R,Thiede C,Viehmann S,Weber C,Wilhelm

更新日期：2000-10-01 00:00:00

abstract：:Myelodysplastic syndrome (MDS) in children is often considered as a variant of acute myeloid leukemia (AML) and frequently treated as such. However, there are very few reported data on the outcome following AML treatment. We analyzed 20 consecutive cases of de novo MDS treated in Denmark according to the NOPHO AML pro...

journal_title：Leukemia

authors： Hasle H,Kerndrup G,Yssing M,Clausen N,Ostergaard E,Jacobsen N,Jacobsen BB

更新日期：1996-08-01 00:00:00

abstract：:In acute myeloid leukemia (AML), assessment of minimal residual disease (MRD) by flow cytometry (flow MRD) after induction and consolidation therapy has been shown to provide independent prognostic information. However, data on the value of earlier flow MRD assessment are lacking. Therefore, the value of flow MRD dete...

journal_title：Leukemia

authors： Köhnke T,Sauter D,Ringel K,Hoster E,Laubender RP,Hubmann M,Bohlander SK,Kakadia PM,Schneider S,Dufour A,Sauerland MC,Berdel WE,Büchner T,Wörmann B,Braess J,Hiddemann W,Spiekermann K,Subklewe M

更新日期：2015-02-01 00:00:00

abstract：:A total of 1111 children with acute myeloblastic leukaemia (AML) were treated in four consecutive Berlin-Frankfurt-Münster (BFM) studies from 1978 to 1998. The first cooperative trial AML-BFM 78 established intensive chemotherapy with seven drugs, CNS irradiation and 2-year maintenance, achieving a long-term survival ...

journal_title：Leukemia

authors： Creutzig U,Zimmermann M,Ritter J,Reinhardt D,Hermann J,Henze G,Jürgens H,Kabisch H,Reiter A,Riehm H,Gadner H,Schellong G

更新日期：2005-12-01 00:00:00

abstract：:Cytokines regulate proliferation and differentiation of hematopoietic progenitor cells. Recently it has been clarified that physiological cell death, apoptosis plays important role of hematopoiesis. So we evaluated the effects of granulocyte-colony stimulating factor (G-CSF) on leukemic cells, especially focused on ap...

journal_title：Leukemia

authors： Handa A,Kashimura T,Kawano N,Yamamoto A,Yoshida S,Jinnai I,Murohashi I,Bessho M,Hirashima K

更新日期：1997-04-01 00:00:00

abstract：:Inorganic arsenic trioxide (As(2)O(3)) is a highly effective treatment for acute promyelocytic leukemia (APL). However, other cancers do not respond well to this form of arsenic at clinically achievable doses. We tested a novel arsenical, S-dimethylarsino-glutathione (darinaparsin) for efficacy in various malignancies...

journal_title：Leukemia

authors： Diaz Z,Mann KK,Marcoux S,Kourelis M,Colombo M,Komarnitsky PB,Miller WH Jr

更新日期：2008-10-01 00:00:00

abstract：:We investigated the effect of the histone deacetylase inhibitors (HDIs), trichostatin A and trapoxin A on leukemia cells and cell lines from the viewpoint of differentiation induction. TSA induced differentiation in erythroid cell lines by itself, whereas it synergistically enhanced the differentiation that was direct...

journal_title：Leukemia

authors： Kosugi H,Towatari M,Hatano S,Kitamura K,Kiyoi H,Kinoshita T,Tanimoto M,Murate T,Kawashima K,Saito H,Naoe T

更新日期：1999-09-01 00:00:00

abstract：:Reduced-intensity conditioning (RIC) regimens have been increasingly used as an alternative to conventional myeloablative conditioning (MAC) regimens for elderly patients, for patients medically infirm to qualify for conventional allogeneic stem cell transplantation (SCT), and for disorders in which traditional MAC-SC...

journal_title：Leukemia

authors： Jiménez M,Ercilla G,Martínez C

更新日期：2007-08-01 00:00:00

abstract：:We established the continuous growth of WEHI-3B D+ cells in protein-free chemically defined F-12 medium by stepwise decreases in the concentration of fetal calf serum. This cell line, designated as WEHI-3B-Y1, has now been propagated in protein-free F-12 medium for 3 years. The population-doubling time of the cells in...

journal_title：Leukemia

authors： Kajigaya Y,Ikuta K,Sasaki H,Matsuyama S

更新日期：1990-10-01 00:00:00

abstract：:In chronic lymphocytic leukemia (CLL), stabilizing mutations of NOTCH1, affecting up to 10-15% of cases, have been associated to poor prognosis, disease progression and refractoriness to chemotherapy. NOTCH1 mutations are significantly overrepresented in trisomy 12 CLL, a disease subset frequently expressing CD49d, th...

journal_title：Leukemia

authors： Benedetti D,Tissino E,Pozzo F,Bittolo T,Caldana C,Perini C,Martorelli D,Bravin V,D'Agaro T,Rossi FM,Bomben R,Santinelli E,Zaja F,Pozzato G,Chiarenza A,Di Raimondo F,Del Poeta G,Rossi D,Gaidano G,Dal Bo M,Gattei V

更新日期：2018-03-01 00:00:00

abstract：:Osteolytic bone disease in multiple myeloma (MM) is caused by enhanced osteoclast (OCL) activation and inhibition of osteoblast function. Lenalidomide and bortezomib have shown promising response rates in relapsed and newly diagnosed MM, and bortezomib has recently been reported to inhibit OCLs. We here investigated t...

journal_title：Leukemia

authors： Breitkreutz I,Raab MS,Vallet S,Hideshima T,Raje N,Mitsiades C,Chauhan D,Okawa Y,Munshi NC,Richardson PG,Anderson KC

更新日期：2008-10-01 00:00:00

abstract：:Relapse of malignant disease remains the major complication in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) after hematopoietic cell transplantation (HCT) with reduced-intensity conditioning (RIC). In this study, we investigated the predictive value of disease-specific markers (DSMs), d...

journal_title：Leukemia

authors： Lange T,Hubmann M,Burkhardt R,Franke GN,Cross M,Scholz M,Leiblein S,Al-Ali HK,Edelmann J,Thiery J,Niederwieser D

更新日期：2011-03-01 00:00:00

abstract：:Positive selection of CD34+ cells has applications in diagnostic pathology, in peripheral blood and bone marrow transplantation, and in studies on the function and regulation of primitive haemopoietic stem cells. Antibody-coated magnetic microspheres (dynabeads) can be used to isolate these cells by positive selection...

journal_title：Leukemia

authors： Grimsley PG,Amos TA,Gordon MY,Greaves MF

更新日期：1993-06-01 00:00:00

abstract：:The role of endothelial progenitor cell (EPC)-mediated vasculogenesis in hematological malignancies is not well explored. Here, we showed that EPCs are mobilized from the bone marrow (BM) to the peripheral blood at early stages of multiple myeloma (MM); and recruited to MM cell-colonized BM niches. Using EPC-defective...

journal_title：Leukemia

authors： Moschetta M,Mishima Y,Kawano Y,Manier S,Paiva B,Palomera L,Aljawai Y,Calcinotto A,Unitt C,Sahin I,Sacco A,Glavey S,Shi J,Reagan MR,Prosper F,Bellone M,Chesi M,Bergsagel LP,Vacca A,Roccaro AM,Ghobrial IM

更新日期：2016-05-01 00:00:00

abstract：:Disturbances in the regulation of the balance between the fibrinolytic and procoagulant properties of leukemic cells may contribute to the coagulopathy of acute leukemia. The coagulant response to a number of stimuli is regulated by the expression of tissue factor, but the role of the plasminogen activator inhibitors,...

journal_title：Leukemia

authors： Dickinson JL,Antalis TM

更新日期：1993-06-01 00:00:00

abstract：:Follicular lymphoma is a low grade malignancy characterized by the translocation t(14;18), which involves the putative oncogene bcl-2. We describe a 73-year-old patient presenting with Burkitt acute lymphoblastic leukemia (B-ALL) L3 (Burkitt type), whose cells had the following immunophenotype: CD19+, CD22+, HLA-DR+, ...

journal_title：Leukemia

authors： Brito-Babapulle V,Crawford A,Khokhar T,Laffan M,Matutes E,Fairhead S,Catovsky D

更新日期：1991-01-01 00:00:00

abstract：:Clinical characteristics, treatment response and outcome were evaluated in children with Down's syndrome (DS) and acute lymphoblastic leukemia (ALL) as compared to other children with ALL (NDS). Sixty-one DS and 4049 NDS patients, receiving intensive antileukemic treatment during four consecutive trials (ALL-BFM 81, 8...

journal_title：Leukemia

authors： Dördelmann M,Schrappe M,Reiter A,Zimmermann M,Graf N,Schott G,Lampert F,Harbott J,Niemeyer C,Ritter J,Dörffel W,Nessler G,Kühl J,Riehm H

更新日期：1998-05-01 00:00:00

abstract：:Multiple myeloma is the second most frequent hematological cancer after lymphoma and remains an incurable disease. The pervasive support provided by the bone marrow microenvironment to myeloma cells is crucial for their survival. Here, an unbiased assessment of receptor tyrosine kinases overexpressed in myeloma identi...

journal_title：Leukemia

authors： Frenquelli M,Caridi N,Antonini E,Storti F,Viganò V,Gaviraghi M,Occhionorelli M,Bianchessi S,Bongiovanni L,Spinelli A,Marcatti M,Belloni D,Ferrero E,Karki S,Brambilla P,Martinelli-Boneschi F,Colla S,Ponzoni M,DePinho R

更新日期：2020-01-01 00:00:00