Obesity--a risk factor or a RISK factor for myocardial infarction?

abstract：BACKGROUND AND PURPOSE:The histamine H4 receptor is widely expressed in cells of immune origin and has been shown to play a role in a variety of inflammatory processes mediated by histamine. In this report, we describe the in vitro and in vivo anti-inflammatory properties of a potent histamine H4 receptor antagonist, A...

journal_title：British journal of pharmacology

authors： Strakhova MI,Cuff CA,Manelli AM,Carr TL,Witte DG,Baranowski JL,Vortherms TA,Miller TR,Rundell L,McPherson MJ,Adair RM,Brito AA,Bettencourt BM,Yao BB,Wetter JM,Marsh KC,Liu H,Cowart MD,Brioni JD,Esbenshade TA

更新日期：2009-05-01 00:00:00

abstract：:1. To investigate the role of nitric oxide in epilepsy we have studied the effects of agents which affect nitric oxide synthesis in sound-induced seizures in DBA/2 mice and in genetically epilepsy-prone (GEP) rats. 2. The neuronal selective nitric oxide synthase inhibitor, 7-nitroindazole (7-NI) is anticonvulsant in t...

journal_title：British journal of pharmacology

authors： Smith SE,Man CM,Yip PK,Tang E,Chapman AG,Meldrum BS

更新日期：1996-09-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) increased adenosine 3' : 5'-cyclic monophosphate (cyclic AMP) formation in tracheal epithelial cells and concomitantly decreased the production/secretion of immunoreactive endothelin (irET). Naturally occurring prostanoids and selective and non-selective EP receptor agonists showed the foll...

journal_title：British journal of pharmacology

authors： Pelletier S,Dubé J,Villeneuve A,Gobeil F Jr,Yang Q,Battistini B,Guillemette G,Sirois P

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to determine whether the apelin/APJ system is altered in human cardiovascular disease by investigating whether the expression of apelin or its receptor is altered at the protein level. EXPERIMENTAL APPROACH:Radioligand binding studies were used to determine apelin recep...

journal_title：British journal of pharmacology

authors： Pitkin SL,Maguire JJ,Kuc RE,Davenport AP

更新日期：2010-08-01 00:00:00

abstract：:The effect of the selective serotonin reuptake inhibitor fluoxetine was examined on the 5-HT4 receptor-mediated relaxation in the rat isolated ileum. Fluoxetine unsurmountably antagonized the relaxation to exogenous 5-HT with abolition of the response at 10 microM. Fluoxetine (10 microM) also caused a gradual loss of ...

journal_title：British journal of pharmacology

authors： Tuladhar BR,Costall B,Naylor RJ

更新日期：2002-05-01 00:00:00

abstract：:1. Intrasplenic injection of bradykinin (BK) induced a dose-dependent pressor response in the anaesthetized cat, with an ED50 of 0.98 +/- 0.43 nmol. In contrast, intrasplenic administration of desArg9bradykinin (desArg9BK) was without significant effect at doses of up to 200 nmol. 2. Intravenously administered BK indu...

journal_title：British journal of pharmacology

authors： Louttit JB,Coleman RA

更新日期：1993-12-01 00:00:00

abstract：:1 We have examined the effect of the histone deacetylase inhibitors apicidin, trichostatin A (TSA) and n-butyrate on the histone acetylation and the differentiation of human eosinophilic leukemia HL-60 clone 15 cells into eosinophils. 2 Viability of the cells incubated with apicidin (100 nm), TSA (30 nm) or n-butyrate...

journal_title：British journal of pharmacology

authors： Ishihara K,Hong J,Zee O,Ohuchi K

更新日期：2004-07-01 00:00:00

abstract：:1 Hypothalamic blood flow (HBF) was measured in conscious rabbits by the 133xenon washout technique. 2 Substance P in a dose of 50 or 500 ng increases HBF while 5 ng is without effect. 3 Cholinoceptor blockade, with either atropine or mecamylamine abolishes the vasodilator effect of substance P. 4 Chemical sympathecto...

journal_title：British journal of pharmacology

authors： Klugman KP,Lembeck F,Markowitz S,Mitchell G,Rosendorff C

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:An alteration in the communication between the innate and adaptive immune cells is a hallmark of ulcerative colitis (UC). Semaphorin-3E (SEMA3E), a secreted guidance protein, regulates various immune responses. EXPERIMENTAL APPROACH:We investigated the expression of SEMA3E in colonic biopsies of...

journal_title：British journal of pharmacology

authors： Kermarrec L,Eissa N,Wang H,Kapoor K,Diarra A,Gounni AS,Bernstein CN,Ghia JE

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is well known that adenine-based purines exert multiple effects on pain transmission. However, less attention has been given to the potential effects of guanine-based purines on pain transmission. The aim of this study was to investigate the effects of intraperitoneal (i.p.) and oral (p.o.) ad...

journal_title：British journal of pharmacology

authors： Schmidt AP,Böhmer AE,Schallenberger C,Antunes C,Tavares RG,Wofchuk ST,Elisabetsky E,Souza DO

更新日期：2010-03-01 00:00:00

abstract：:1 The effect of potassium channel opening compounds has been investigated in the smooth muscle of rabbit aorta under Ca-free conditions. Examination of the characteristics of the response has been performed using cromakalim as the prototype compound. 2 In order of potency, Ro 31-6930, cromakalim, minoxidil sulphate an...

journal_title：British journal of pharmacology

authors： Duty S,Weston AH

更新日期：1992-12-01 00:00:00

abstract：:1. The type of endothelin (ET) receptor located on the myenteric neurones of guinea-pig ileum was determined by receptor autoradiography and function of the receptor was examined by release experiments of acetylcholine (ACh) from the longitudinal muscle myenteric plexus (LM-MP) preparations. 2. Specific [125I]-ET-1 bi...

journal_title：British journal of pharmacology

authors： Yoshimura M,Yamashita Y,Kan S,Niwa M,Taniyama K

更新日期：1996-07-01 00:00:00

abstract：:1. The interaction between endogenous nitric oxide (NO) and factors from the rat submandibular salivary gland such as epidermal growth factor (EGF) on gastric mucosal integrity in the rat has been investigated. 2. Bolus administration of the NO synthase inhibitor, NG nitro-L-arginine methyl ester (L-NAME; 6.25-50 mg k...

journal_title：British journal of pharmacology

authors： Tepperman BL,Soper BD

更新日期：1993-09-01 00:00:00

abstract：:1. Pre-eclampsia is a serious pregnancy disorder associated with widespread activation of the maternal vascular endothelium. Recent evidence implicates a role for oxidative stress in the aetiology of this condition. 2. Reactive oxygen species, particularly superoxide anions, invokes endothelial cell activation through...

journal_title：British journal of pharmacology

authors： Crocker IP,Kenny LC,Thornton WA,Szabo C,Baker PN

更新日期：2005-03-01 00:00:00

abstract：:BACKGROUND AND PURPOSE Selective hyperpolarization activated, cyclic nucleotide-gated channel (HCN) blockers represent an important therapeutic goal due to the wide distribution and multiple functions of these proteins, representing the molecular correlate of f- and h-current (I(f) or I(h) ). Recently, new compounds ...

journal_title：British journal of pharmacology

authors： Del Lungo M,Melchiorre M,Guandalini L,Sartiani L,Mugelli A,Koncz I,Szel T,Varro A,Romanelli MN,Cerbai E

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Bleomycin (BLM), one of the most common sclerosants, is often used to treat venous malformations (VMs). The present study was designed to investigate whether endothelial mesenchymal transition (EndoMT) contributes to the therapeutic effects of BLM. EXPERIMENTAL APPROACH:Endothelial and mesenchym...

journal_title：British journal of pharmacology

authors： Zhang W,Chen G,Ren JG,Zhao YF

更新日期：2013-11-01 00:00:00

abstract：:1 The influence of dopamine receptor agonists on gastric acid secretion stimulated by thyrotropin-releasing hormone (TRH) was studied in the perfused stomach of anaesthetized rats. 2 Intraventricular TRH produced a dose-dependent stimulation of basal gastric acid secretion. 3 Pretreatment with apomorphine, bromocripti...

journal_title：British journal of pharmacology

authors： Maeda-Hagiwara M,Watanabe K

更新日期：1983-05-01 00:00:00

abstract：:1. N-formyl peptides (e.g. fMLP; N-formyl-L-methionyl-L-leucyl-phenylalanine) are potent mediators for inflammatory reactions. We report functional expression in Xenopus oocytes of human fMLP-R98 cDNA, without co-expression of the promiscuous G-protein subunit, Galpha-16. 2. Stimulation of voltage-clamped oocytes (-70...

journal_title：British journal of pharmacology

authors： Wittmann S,Fröhlich D,Daniels S

更新日期：2002-03-01 00:00:00

abstract：:1. In the presence of indomethacin (IM, 10 microM) and N omega-nitro-L- arginine (L-NOARG, 0.3 mM), acetylcholine (ACh) induces an endothelium-dependent smooth muscle hyperpolarization and relaxation in the rat isolated hepatic artery. The potassium (K) channel inhibitors, tetrabutylammonium (TBA, 1 mM) and to a lesse...

journal_title：British journal of pharmacology

authors： Zygmunt PM,Högestätt ED

更新日期：1996-04-01 00:00:00

abstract：:1. Insulin antibodies were induced in young guinea-pigs of both sexes weighing 300-400 g and housed in a room maintained at 28 degrees C+/-2 degrees C, by subcutaneous injection of 2 ml of freshly prepared insulin antigen emulsion between the shoulders once every month.2. To estimate the titre of serum antibody the se...

journal_title：British journal of pharmacology

authors： Gulati OD,Patel DG

更新日期：1971-05-01 00:00:00

abstract：:1. In rats, recovery of sensory-motor function following a crush lesion of the sciatic or tibial nerve was monitored by measuring foot reflex withdrawal from a local noxious stimulation of the foot sole. 2. Putative neurotrophic compounds were tested on this functional recovery model: melanocortins (peptides derived f...

journal_title：British journal of pharmacology

authors： Van der Zee CE,Brakkee JH,Gispen WH

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lysophosphatidylinositol (LPI), a lipid signalling molecule, activates GPR55 and elevates intracellular Ca(2+). Here, we examine the actions of LPI in the rat resistance mesenteric artery and Ca(2+) responses in endothelial cells isolated from the artery. EXPERIMENTAL APPROACH:Vascular responses...

journal_title：British journal of pharmacology

authors： AlSuleimani YM,Hiley CR

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although trace amines (TAs) are historically considered 'false neurotransmitters' on the basis of their ability to induce catecholamine release, there is evidence that they directly affect neuronal activity via TA receptors, ligand-gated receptor channels and/or sigma receptors. Here, we have inv...

journal_title：British journal of pharmacology

authors： Ledonne A,Federici M,Giustizieri M,Pessia M,Imbrici P,Millan MJ,Bernardi G,Mercuri NB

更新日期：2010-07-01 00:00:00

abstract：:1. The effects of the selective alpha 2-adrenoceptor agonist, medetomidine, were assessed on plasma levels of immunoreactive atrial natriuretic peptide (IR-ANP), haemodynamics and on urine water and solute excretion in conscious, chronically cannulated, 7 month-old spontaneously hypertensive (SHR) and age-matched Wist...

journal_title：British journal of pharmacology

authors： Ruskoaho H,Leppäluoto J

更新日期：1989-05-01 00:00:00

abstract：:The effect of trimetazidine (TMZ), an anti-anginal drug, on the mechanical response of the guinea-pig ductus arteriosus placed under conditions of mild hypoxia (PO2 approximately equal to 75 mmHg) was investigated. When the PO2 of the bathing solution was 75 mmHg, TMZ caused a dose-dependent increase in tension. The m...

journal_title：British journal of pharmacology

authors： Garnier D,Roulet MJ

更新日期：1985-02-01 00:00:00

abstract：:We have shown earlier that activation of metabotropic glutamate (mGlu) receptors using a group I-specific mGlu receptor agonist, (RS)-3,5-dihydroxyphenylglycine (DHPG), can induce long-term depression (LTD) in the CA1 region of the hippocampus. In an attempt to determine the signal transduction mechanisms involved in ...

journal_title：British journal of pharmacology

authors： Schnabel R,Kilpatrick IC,Collingridge GL

更新日期：2001-03-01 00:00:00

abstract：:Extensive in vitro and in vivo studies have shown that cannabinoid drugs have neuroprotective properties and suggested that the endocannabinoid system may be involved in endogenous neuroprotective mechanisms. On the other hand, neurotoxic effects of cannabinoids in vitro and in vivo were also described. Several possib...

journal_title：British journal of pharmacology

authors： Sarne Y,Asaf F,Fishbein M,Gafni M,Keren O

更新日期：2011-08-01 00:00:00

abstract：:1. A grease-gap technique has been used to measure d.c. potentials, in response to the application of excitatory amino acids and electrical stimulation of the Schaffer collateral-commissural pathway, in the CA1 region of rat hippocampal slices. The actions of L-glutamate (L-Glu) have been quantified and compared to th...

journal_title：British journal of pharmacology

authors： Frenguelli BG,Blake JF,Brown MW,Collingridge GL

更新日期：1991-02-01 00:00:00

abstract：:Rats were placed on either a low sodium intake (low sodium diet 0.025% dry weight, tap water for drinking) or a high sodium intake (normal sodium diet 0.45% dry weight, 0.9% saline for drinking) for 10 days. The pressor-response curve to angiotensin II in rats previously on a high sodium intake was shifted to the left...

journal_title：British journal of pharmacology

authors： Jones DR,Penner SB,Smyth DD

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pulmonary arterial hypertension (PAH) is characterized by enhanced pulmonary vascular resistance, right ventricular hypertrophy and increased right ventricular systolic pressure. Here, we investigated the effects of a N-acylhydrazone derivative, 3,4-dimethoxyphenyl-N-methyl-benzoylhydrazide (LASS...

journal_title：British journal of pharmacology

authors： Alencar AK,Pereira SL,Montagnoli TL,Maia RC,Kümmerle AE,Landgraf SS,Caruso-Neves C,Ferraz EB,Tesch R,Nascimento JH,de Sant'Anna CM,Fraga CA,Barreiro EJ,Sudo RT,Zapata-Sudo G

更新日期：2013-07-01 00:00:00