Abstract：
BACKGROUND:The mechanisms explaining morphological electrocardiogram (ECG) changes and increased troponin T (TnT) in acute stroke are unclear. The aims of the present study were to assess the prevalence of ECG and TnT changes in acute ischaemic stroke, to investigate whether ischaemic-like ECG changes correlate to a rise in TnT and to examine whether ECG changes and elevated TnT predict a poor short-time outcome. METHODS:From 2000 to 2002 a total of 279 patients suffering from acute ischaemic stroke were included prospectively in the present study. ECG was carried out at admission and on day 1 in all patients. TnT was analysed at admission and on day 1. RESULTS:The most frequent ECG changes were: prolonged QTc 36.0%, ST depression 24.5%, atrial fibrillation 19.9% and T wave inversion 17.8%. In logistic regression analyses, ST depression and Q waves were significantly associated with a rise in TnT. TnT was elevated (>0.04 microg L(-1)) in 26 patients (9.6%). In logistic regression analyses, a rise in TnT was significantly associated with a poor short-term outcome (modified Rankin scale >3). CONCLUSION:ECG changes are prevalent in acute ischaemic stroke. ST depression and Q waves are related to an increase in TnT, suggesting that these ECG changes may indicate coexisting ischaemic heart disease. A rise in TnT predicts a poor outcome. Patients with acute ischaemic stroke should be offered adequate treatment with secondary prevention and preferably a follow-up with focus on cardiologic as well as neurological aspects.
journal_name
J Intern Medjournal_title
Journal of internal medicineauthors
Fure B,Bruun Wyller T,Thommessen Bdoi
10.1111/j.1365-2796.2006.01639.xsubject
Has Abstractpub_date
2006-06-01 00:00:00pages
592-7issue
6eissn
0954-6820issn
1365-2796pii
JIM1639journal_volume
259pub_type
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doi：10.1111/j.1365-2796.2004.01427.x
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doi：10.1111/j.1365-2796.2005.01601.x
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doi：10.1046/j.1365-2796.1999.00461.x
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of internal medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2796.1989.tb00089.x
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doi：10.1111/j.1365-2796.2008.01945.x
更新日期：2008-05-01 00:00:00
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