Abstract:
:A disintegrin and metalloproteases (ADAMs) are zinc-dependent trans-membrane metalloproteases that shed the extracellular domains of membrane-bound growth factors, cytokines and receptors. Key functions of ADAMs have emerged in ErbB signalling pathways as being sheddases for multiple ErbB ligands. As the ErbB pathway is a validated target for anti-cancer drugs, the upstream activators of ErbB ligands, their sheddases, now enter the spotlight as new drug targets in the ErbB pathway. ADAMs are involved not only in tumour cell proliferation but also in angiogenesis and metastasis. Therefore, strategies targeting ADAMs might be an important complement to existing anti-ErbB approaches.
journal_name
Expert Opin Investig Drugsjournal_title
Expert opinion on investigational drugsauthors
Zhou BB,Fridman JS,Liu X,Friedman SM,Newton RC,Scherle PAdoi
10.1517/13543784.14.6.591subject
Has Abstractpub_date
2005-06-01 00:00:00pages
591-606issue
6eissn
1354-3784issn
1744-7658journal_volume
14pub_type
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