Aging, telomeres, and atherosclerosis.

abstract：OBJECTIVE:The alpha adrenoceptor antagonist phentolamine prevents ischaemia related arrhythmias in rat, guinea pig, and cat heart. This effect has been related to the attenuation of ischaemia induced shortening of the action potential and has been ascribed to its alpha adrenoceptor antagonist properties. The aim of thi...

journal_title：Cardiovascular research

authors： Wilde AA,Veldkamp MW,van Ginneken AC,Opthof T

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:Cholinergic vasodilation has been thought to play little if any role in the regulation of blood pressure in humans. Autonomic denervation potentiates the vasoconstriction evoked by nitric oxide synthase inhibition in humans, but the mechanism is unclear. We hypothesized that this may be related to loss of neu...

journal_title：Cardiovascular research

authors： Lepori M,Sartori C,Duplain H,Nicod P,Scherrer U

更新日期：2001-09-01 00:00:00

abstract：:Exaggerated cardiovascular responsiveness is common in young men and may cause non-specific symptoms and poor performance. Conventional autonomic function tests are not clinically useful. We have therefore designed a thermal entrainment method to evaluate sympathetic and parasympathetic cardiovascular function in subj...

journal_title：Cardiovascular research

authors： Lindqvist A,Parviainen P,Kolari P,Tuominen J,Välimäki I,Antila K,Laitinen LA

更新日期：1989-03-01 00:00:00

abstract：AIMS:Sleep disturbances exhibit a strong social patterning, and inadequate sleep has been associated with adverse health outcomes, including cardiovascular disorders (CVD). However, the contribution of sleep to socioeconomic inequalities in CVD is unclear. This study pools data from eight European cohorts to investigat...

journal_title：Cardiovascular research

authors： Petrovic D,Haba-Rubio J,de Mestral Vargas C,Kelly-Irving M,Vineis P,Kivimäki M,Nyberg S,Gandini M,Bochud M,Vollenweider P,d'Errico A,Barros H,Fraga S,Goldberg M,Zins M,Steptoe A,Delpierre C,Heinzer R,Carmeli C,Chade

更新日期：2020-07-01 00:00:00

abstract：AIMS:Neovascularization is an important element of long-term functional recovery during chronic ischaemia. We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI). METHODS AND RESULTS:The femoral artery was...

journal_title：Cardiovascular research

authors： Tongers J,Knapp JM,Korf M,Kempf T,Limbourg A,Limbourg FP,Li Z,Fraccarollo D,Bauersachs J,Han X,Drexler H,Fiedler B,Wollert KC

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:Although aldosterone has been implicated in the pathogenesis of cardiac hypertrophy and heart failure, its cellular mechanism of action on cardiomyocyte function is not yet completely elucidated. This study was designed to investigate the effect of aldosterone on calcium channel expression and cardiomyocyte c...

journal_title：Cardiovascular research

authors： Lalevée N,Rebsamen MC,Barrère-Lemaire S,Perrier E,Nargeot J,Bénitah JP,Rossier MF

更新日期：2005-08-01 00:00:00

abstract：:Congenital coronary artery anomalies are of major significance in clinical cardiology and cardiac surgery due to their association with myocardial ischaemia and sudden death. Such anomalies are detectable by imaging modalities and, according to various definitions, their prevalence ranges from 0.21 to 5.79%. This cons...

journal_title：Cardiovascular research

authors： Pérez-Pomares JM,de la Pompa JL,Franco D,Henderson D,Ho SY,Houyel L,Kelly RG,Sedmera D,Sheppard M,Sperling S,Thiene G,van den Hoff M,Basso C

更新日期：2016-02-01 00:00:00

abstract：AIM:To assess whether endothelin-1 (ET-1) induces the in vivo expression of inflammatory-related proteins, namely cyclooxygenase-2 (COX-2) and tissue factor, in the myocardium and circulating leukocytes of guinea-pigs. The involvement of platelets was also analyzed. METHODS:ET-1 (0.013 microg/min) was infused to male ...

journal_title：Cardiovascular research

authors： Molero L,Farré J,García-Mendez A,Jiménez Mateos-Caceres P,Carrasco Martín C,Millás I,Navarro F,Córdoba M,Casado S,López-Farré A

更新日期：2003-01-01 00:00:00

abstract：:The effect on the microcirculation of long term administration of the alpha 1 blocker prazosin, which increases peripheral blood flow, was studied in skeletal muscles with differing metabolic profiles. Prazosin (50 mg.litre-1), given ad libitum for 5 weeks in the drinking water, resulted in an increase in capillarity ...

journal_title：Cardiovascular research

authors： Dawson JM,Hudlická O

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVES:Plasma endothelin (ET) concentrations are increased in heart failure. The aims of the present study were to investigate to what extent cardiac ET mRNA expression is induced in ischemic heart failure and whether there may be compensatory downregulation of myocardial mRNA levels for the ETA and ETB receptor su...

journal_title：Cardiovascular research

authors： Tønnessen T,Christensen G,Oie E,Holt E,Kjekshus H,Smiseth OA,Sejersted OM,Attramadal H

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:The present work is aimed at elucidating the signalling pathway(s) triggered by activation of A(2A) receptors involved in the facilitation of noradrenaline release in rat tail artery as an attempt to clarify their role in the cardiovascular system. METHODS:Electrically evoked (5 Hz, 100 pulses, 1 ms) tritium...

journal_title：Cardiovascular research

authors： Fresco P,Diniz C,Gonçalves J

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:The aim was to determine the ionic basis of action potential lengthening associated with cardiac hypertrophy. METHODS:Action potentials and ionic currents of left ventricular myocytes isolated from normal and hypertrophied hearts were recorded with patch pipettes. Since cardiac hypertrophy is a time dependen...

journal_title：Cardiovascular research

authors： Cerbai E,Barbieri M,Li Q,Mugelli A

更新日期：1994-08-01 00:00:00

abstract：AIMS:Macrophage-related oxidative stress plays an important role in the inflammatory process in atherosclerosis. Recently, dextromethorphan (DXM), a common cough-suppressing ingredient with a high safety profile, was found to inhibit the activation of microglia, the resident macrophage in the nervous system. We investi...

journal_title：Cardiovascular research

authors： Liu SL,Li YH,Shi GY,Tang SH,Jiang SJ,Huang CW,Liu PY,Hong JS,Wu HL

更新日期：2009-04-01 00:00:00

abstract：:When the vagus nerves are stimulated with one burst of pulses per minute, but each burst is placed at a different time in the cardiac cycle, a "vagal effect curve" can be derived which displays the changes in cardiac cycle length (CCL) as a function of the elapsed time from the stimulus. This curve consists of a prima...

journal_title：Cardiovascular research

authors： Wallick DW,Valencic F,Fratianne RB,Levy MN

更新日期：1984-02-01 00:00:00

abstract：AIMS:Both cyclooxygenase-2 (COX-2) and the transcription factor signal transducer and activator of transcription 3 (Stat3) are involved in adaptive growth and survival of cardiomyocytes. In ventricular cardiomyocytes, prostaglandin E(2) (PGE(2)), a major COX-2 product, leads to adaptive growth via Stat3 activation, but...

journal_title：Cardiovascular research

authors： Frias MA,Somers S,Gerber-Wicht C,Opie LH,Lecour S,Lang U

更新日期：2008-10-01 00:00:00

abstract：AIMS:Angiotensin II is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells, exposure to angiotensin II induces mitochondrial fission via dynamin-related protein 1 (Drp1). However, pathophysiological relevance of mitochondrial morphology in angiotensin II...

journal_title：Cardiovascular research

authors： Cooper HA,Cicalese S,Preston KJ,Kawai T,Okuno K,Choi ET,Kasahara S,Uchida HA,Otaka N,Scalia R,Rizzo V,Eguchi S

更新日期：2020-05-08 00:00:00

abstract：OBJECTIVE:The aim was to evaluate the hypothesis that the oxygen demand of stimulated myocardium is downregulated and ischaemia avoided when oxygen supply is limited. METHODS:Isoprenaline stimulation during reduced coronary perfusion pressure or moderate coronary hypoxaemia was studied in relation to myocardial oxygen...

journal_title：Cardiovascular research

authors： Lee SC,Downey HF

更新日期：1993-08-01 00:00:00

abstract：:Intracellular acidosis exerts substantial effects on the contractile performance of the heart. Soon after the onset of acidosis, contractility diminishes, largely due to a decrease in myofilament Ca(2+) responsiveness. This decrease in contractility is followed by a progressive recovery that occurs despite the persist...

journal_title：Cardiovascular research

authors： Mattiazzi A,Vittone L,Mundiña-Weilenmann C

更新日期：2007-03-01 00:00:00

abstract：AIMS:Elderly patients with heart failure with reduced ejection fraction (HFrEF) have worse prognosis and less often receive guideline-recommended therapies. We aim to better understand the underlying pathophysiological processes associated with aging in HFrEF potentially leading to targeted therapies in this vulnerable...

journal_title：Cardiovascular research

authors： Ferreira JP,Ouwerkerk W,Santema BT,van Veldhuisen DJ,Lang CC,Ng LL,Anker SD,Dickstein K,Metra M,Cleland JGF,Nilesh SJ,Filippatos G,Aboumsallem JP,de Boer RA,Figarska S,Sama IE,Voors AA,Zannad F

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:After-depolarization associated arrhythmias are frequently observed in heart failure and associated with spontaneous calcium release from sarcoplasmic reticulum (SR), calcium after-transients. We hypothesize that disturbed SR calcium handling underlies calcium after-transients in heart failure (HF). METHODS:...

journal_title：Cardiovascular research

authors： Baartscheer A,Schumacher CA,Belterman CN,Coronel R,Fiolet JW

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To examine whether altered PCO2 or HCO3- at normal pH potentiate agonist-induced vasoconstriction of small pulmonary arteries, and if so to determine the mechanism. METHODS:Small intrapulmonary arteries (IPA) from rats were mounted on a myograph and PGF2alpha (3 microM)-induced tension recorded before and 40...

journal_title：Cardiovascular research

authors： Vanková M,Snetkov VA,Knock GA,Aaronson PI,Ward JP

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:The restitution mechanism has been the focus of attention as the possible mechanism behind ventricular fibrillation (VF). However, its contribution in chronic ischemic heart has not been established. METHODS:We investigated chronic ischemic dogs with occlusion of left anterior descending artery. Sixty unipol...

journal_title：Cardiovascular research

authors： Yuuki K,Hosoya Y,Kubota I,Yamaki M

更新日期：2004-09-01 00:00:00

abstract：:Changes in left ventricular internal diameter resulting from increasing intrapericardial pressure induced by increasing the pericardial fluid volume were studied in closed chest, anaesthetized dogs. Left ventricular internal diameters were measured by placing an ultrasonic dimension catheter in the left ventricle at t...

journal_title：Cardiovascular research

authors： Pegram BL,Kardon MB,Bishop VS

更新日期：1975-11-01 00:00:00

abstract：OBJECTIVE:Decay kinetics of the voltage-gated L-type Ca(2+) current (I(CaL)) control the magnitude of Ca(2+) influx during the cardiac action potential. We investigated the influence of changes in diastolic membrane potential on I(CaL) decay kinetics in cardiac cells. METHODS:Cells were isolated enzymatically from rat...

journal_title：Cardiovascular research

authors： Barrère-Lemaire S,Piot C,Leclercq F,Nargeot J,Richard S

更新日期：2000-08-01 00:00:00

abstract：Aims:RHOA-ROCK signalling regulates cell migration, proliferation, differentiation, and transcription. RHOA is expressed in the developing cardiac conduction system in chicken and mice. In early development, the entire sinus venosus myocardium, including both the transient left-sided and the definitive sinoatrial node ...

journal_title：Cardiovascular research

authors： Vicente-Steijn R,Kelder TP,Tertoolen LG,Wisse LJ,Pijnappels DA,Poelmann RE,Schalij MJ,deRuiter MC,Gittenberger-de Groot AC,Jongbloed MRM

更新日期：2017-08-01 00:00:00

abstract：:The intrinsic ability of resistance arteries to respond to transmural pressure is the single most important determinant of their function. Despite an ever-growing catalogue of signalling pathways that underlie the myogenic response, it remains an enigmatic mechanism. The myogenic response's mechanistic diversity has l...

journal_title：Cardiovascular research

authors： Lidington D,Schubert R,Bolz SS

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:Prior studies have shown that the performance of the left ventricle on any one beat is influenced by the mechanical events of the previous beat, a phenomenon called "previous-beat contraction history". This previous-beat contraction history, which appears to be an interplay between the mechanical events of o...

journal_title：Cardiovascular research

authors： Slinker BK,Tobias AH

更新日期：1996-07-01 00:00:00

abstract：:Although substantial information has accumulated over the past decade, many gaps remain in our understanding of the regulation of contractility and modulation of inotropic responsiveness in the developing heart. There are several important problems facing investigators in the field of developmental cardiology. Respons...

journal_title：Cardiovascular research

authors： Artman M

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Heme oxygenases (HO) are the rate-limiting enzymes in heme degradation, catalyzing the breakdown of heme to equimolar quantities of biliverdin (BV), carbon monoxide (CO), and ferrous iron. The inducible HO isoform, HO-1, confers protection against ischemia/reperfusion (I/R)-injury in the heart. We hypothesize...

journal_title：Cardiovascular research

authors： Tongers J,Fiedler B,König D,Kempf T,Klein G,Heineke J,Kraft T,Gambaryan S,Lohmann SM,Drexler H,Wollert KC

更新日期：2004-08-15 00:00:00

abstract：:In isolated electrically stimulated guinea pig papillary muscles tiapamil exerts a negative inotropic action that corresponds to its presumptive inhibitory effects on the slow-channel-mediated transmembrane Ca2+ influx. However, contractile depression is always accompanied by marked alterations of the normal Na+-carri...

journal_title：Cardiovascular research

authors： Späh F

更新日期：1986-01-01 00:00:00