Abstract:
:Endothelial dysfunction plays an important role in the pathogenesis of cardiac syndrome X, and intracoronary low-dose acetylcholine infusion is a widely used diagnostic modality for studying the coronary artery endothelial function. The authors herein report 2 cases of cardiac syndrome X with coronary artery endothelial dysfunction and microvessel spasm. The findings of non-invasive testing were positive for ischemia. Coronary angiograms appeared entirely normal in both cases. However, the intracoronary infusion of low-dose (1.5-15 microg/minute) acetylcholine demonstrated an impairment of the coronary blood flow response and consequently provoked an ST-segment elevation in an electrocardiogram. The coronary angiograms showed no spasm in the epicardial arteries. These patients are thus suggested to have cardiac syndrome X with microvessel spasms associated with coronary artery endothelial dysfunction.
journal_name
Angiologyjournal_title
Angiologyauthors
Masaki N,Takase B,Satomura K,Akima T,Matsushima Y,Hosaka H,Hamabe A,Kurita A,Ohsuzu Fdoi
10.1177/000331970505600211subject
Has Abstractpub_date
2005-03-01 00:00:00pages
211-6issue
2eissn
0003-3197issn
1940-1574journal_volume
56pub_type
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