Abstract:
:We have recently found that the frequency of OATP-C*15 is significantly higher in patients who experienced myopathy after receiving pravastatin or atorvastatin than in patients without myopathy. However, there were two patients who experienced pravastatin-induced myopathy despite the fact that they did not possess OATP-C*15 or other known mutations of OATP-C that have been reported to decrease the function of OATP-C. In this study, we sequenced all of the exons and exon-intron junctions of OATP-C of the two patients and found a novel mutation in exon 12 of OATP-C in one of the patients. In this mutation (1628T>G), there is a substitution of Leu to Trp at position 543 in transmembrane-spanning domain 10 of OATP-C. However, the frequency of this mutation in the Japanese population appears to be very low (<1%).
journal_name
Drug Metab Pharmacokinetjournal_title
Drug metabolism and pharmacokineticsauthors
Morimoto K,Oishi T,Ueda S,Ueda M,Hosokawa M,Chiba Kdoi
10.2133/dmpk.19.453subject
Has Abstractpub_date
2004-12-01 00:00:00pages
453-5issue
6eissn
1347-4367issn
1880-0920pii
JST.JSTAGE/dmpk/19.453journal_volume
19pub_type
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