Steroid therapy for post-tonsillectomy symptoms in adults: a randomized, placebo-controlled study.

Abstract:

BACKGROUND:Post-operative morbidity following tonsillectomy remains an important clinical problem despite advances in anesthetic and surgical techniques. This study investigated the effect of a one-day course of intravenous dexamethasone on recovery from tonsillectomy. PATIENTS AND METHODS:In a double-blind, randomized, placebo-controlled trial, 30 consecutive adult patients between 18 and 35 years of age, who had no previous or known contraindications to steroid therapy, were randomly assigned at the time of surgery to either a 24-hour course of dexamethasone (3 doses of 6 mg IV) or placebo with the first dose administered during surgery, and subsequent doses given after 8 and 16 hours. The same surgeon treated all patients. Postoperative signs and symptoms, including pain, nausea, vomiting, progress of healing and the degree of granulation, were evaluated for 2 weeks. RESULTS:Patients treated with dexamethasone showed significantly less pain, nausea and vomiting, better healing and less granulation. There were no side effects reported. CONCLUSION:Application of 3 doses of dexamethasone within 24 hours during and after tonsillectomy is advisable because of the reduction of postoperative morbidity, especially pain and edema.

journal_name

Ann Saudi Med

journal_title

Annals of Saudi medicine

authors

Al-Shehri AM

doi

10.5144/0256-4947.2004.365

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

365-7

issue

5

eissn

0256-4947

issn

0975-4466

journal_volume

24

pub_type

临床试验,杂志文章,随机对照试验
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    doi:

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