Abstract：
OBJECTIVES:Both aquaporin (AQP) 1 and the stem-cell factor/C-kit system seem to have a definite role in testis function, but very few studies have been reported in humans, especially in the paediatric age group. With the present study we wanted to investigate the expression of these proteins to better delineate their role in normal and pathologic testes. METHODS:Immunohistology using AQP 1 and C-kit antibodies was performed on paraffin sections of open-testicular biopsies from 32 undescended testes. The testes of cryptorchid patients, with ages ranging from 2 to 15 years, were biopsied during an orchidopexy operation, after obtaining informed consent. Control biopsies, from 8 patients of matched age, were obtained during operations for inguinal hernia or hydrocele, always after obtaining informed consent. Positive results were recorded as diffuse or focal patterns and scored as weak, moderate or strong immunostaining. RESULTS:AQP 1 antibody strongly depicted microvessel endothelial cells, but was unlabeled in endotubular and interstitial cell lines, in both control and undescended testes. The C-kit immunostaining in normal testes revealed a diffuse, strong staining in the cytoplasm of spermatogonia and primary spermatocytes. However, in the undescended testes a focal C-kit immunolabelling was weakly recognized in both spermatogonial and immature Sertoli cells. CONCLUSIONS:These results indicate a direct involvement of AQP 1 in the regulation of fluid transport across the endothelial cell membranes of testicular microvessels. A role of the C-kit receptor protein is also substantiated by its strong expression in the maturing spermatogonia of the normal testes, but was minimally or not recognizable in undescended prepubertal testes.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Nicòtina PA,Romeo C,Arena S,Impellizzeri P,Antonuccio P,Arena F,Zuccarello B,Romeo Gdoi
10.1007/s00383-003-1125-zsubject
Has Abstractpub_date
2004-04-01 00:00:00pages
271-5issue
4eissn
0179-0358issn
1437-9813journal_volume
20pub_type
杂志文章abstract：UNLABELLED:Anorectal malformation (ARM) is a group of significant birth defects with geographic variation in incidence, individual phenotypes and regional geographic subtypes occurring in approximately 1:5,000 live births. Anorectal atresia with gross terminal colonic distension in the presence of an absent anal canal ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00383-013-3346-0
更新日期：2013-12-01 00:00:00
abstract：:Ovarian involvement of acute lymphoblastic leukemia (ALL) without relapse in the bone marrow or other extramedullary site is rare. We report a case of ovarian relapse in a 13-year-old girl who was diagnosed with ALL at the age of 11. A complete remission was induced with the Children Cancer Group 1882 protocol for hig...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-008-2253-2
更新日期：2008-11-01 00:00:00
abstract：:Congenital anterior penile urethral fistula is a rare anomaly; only seven cases have been reported to date. This report outlines the clinical presentation and the embryologic mechanism of a case associated with urethral duplication. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-003-1063-9
更新日期：2003-12-01 00:00:00
abstract：:A 31-year-old man who died of metastatic adenocarcinoma of the sigmoid colon had undergone bilateral ureterosigmoidostomy for exstrophy of the bladder 20 years earlier. The patient never underwent a colonoscopy. Neoplastic transformation at the ureterosigmoid anastomosis must be considered as a possible severe complic...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050458
更新日期：1998-11-01 00:00:00
abstract：AIM OF THE STUDY:The high morbidity and mortality in congenital diaphragmatic hernia (CDH) is attributed to pulmonary hypoplasia and persistent pulmonary hypertension (PH). PH is characterized by increased pulmonary artery smooth muscle cell (SMC) proliferation, suppressed apoptosis as well as endothelial dysfunction. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3606-7
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:We previously showed that meticulous probing and resection of the intrahepatic bile duct stenosis (IHBDS)-causing membrane or septum was effective in preventing hepatolithiasis after choledochal cyst excisions in open surgeries. Then, we introduced this maneuver into laparoscopic choledochal cyst excisions in 2...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4320-7
更新日期：2018-10-01 00:00:00
abstract：:Intestinal ischemia-reperfusion (IIR) is a complex phenomenon causing local and remote tissue destruction, and even multiple-organ failure. To examine the hypothesis that IIR affects renal function, 21-day-old male Sprague-Dawley rats underwent 45 min superior mesenteric artery occlusion and control rats were subjecte...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0834-z
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:Recognition of physical child abuse is imperative for ensuring children's safety. Screening tools (ST) may increase identification of physical abuse; however, the extent of their use is unknown. This study assessed use of STs for physical abuse in children's hospitals and determined attitudes regarding STs. ME...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3916-z
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine if there is a difference between complications for totally implantable central venous catheters (ports) and tunnelled external central venous catheters (external CVCs) that result in early removal of the central venous catheter (CVC) in children and adolescents with acute ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-012-3213-4
更新日期：2012-12-01 00:00:00
abstract：:Gastrointestinal atresia is a major cause of bowel obstruction in the newborn. Experimental models and clinical observations have demonstrated the heterogeneous nature of its pathogenesis. A proportion is due to late intra-uterine vascular insults and some are genetic in nature. Epidemiological studies have found gast...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2138-4
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Variation exists in the diagnostic testing for gastroesophageal reflux (GER) in infants and in the application of surgical therapy. There has been an increase in antireflux surgery (ARS) since the development of laparoscopy but the outcomes in high-risk infants is unclear. This study examines the results of ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4281-x
更新日期：2018-07-01 00:00:00
abstract：:Postoperative abdominal evisceration may lead to high morbidity and mortality. The purpose of the present study was to determine possible risk factors, morbidity and mortality associated with abdominal evisceration in children. A total of 3,591 children underwent abdominal exploration in our clinic between 1983 and 20...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1722-8
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:The aim of the present study was to review the complications and growth after proctocolectomy and ileal J-pouch anal anastomosis (IPAA) in pediatric ulcerative colitis (UC) patients receiving prolonged steroid therapy. PATIENTS AND METHODS:We experienced 209 patients with UC who received IPAA between September...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2577-6
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:Since 1999, complete primary repair of exstrophy has represented a valid alternative in the treatment of exstrophy patients, offering one- stage reconstruction for all components of this malformation in newborns. The vast majority of cases are currently approached within 48/72 h of life, and risk of vascular in...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2745-8
更新日期：2011-04-01 00:00:00
abstract：:Laparoscopy enables surgeons to approach the surgical conditions from a new perspective. Laparoscopic surgery has revolutionized the treatment of choledochal cysts (CDC). Yet, this new technique requires objective evaluations. We have examined the controversies about the CDC dissection, distal common bile duct ligatio...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-013-3266-z
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:to report the early experience with the Kelly procedure for the treatment of bladder exstrophy (BE) in males. MATERIALS AND METHODS:Nine boys with BE were treated at our institute. One had an untouched BE, four had epispadias after neonatal bladder closure, and four were secondary phalloplasties. Data on surgi...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2356-4
更新日期：2009-05-01 00:00:00
abstract：:Children and adolescents affected by ulcerative colitis (UC) frequently require colectomy because of refractory or chronic symptoms. The aim of this paper is to present our experience and 10-year follow-up results of 28 patients who underwent endorectal pull-through (ERPT) as surgical treatment for UC, with special re...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1232-5
更新日期：2004-08-01 00:00:00
abstract：:Three cases of neonatal chylous ascites (CCA) were managed in the neonatal unit, University Hospital, Kuala Lumpur, over the past 9 years. Fetal ascites and polyhydramnios were the sole abnormalities detected in all three babies by antenatal ultrasonography. They were born at 36 weeks' gestation and their birth weight...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/BF01372154
更新日期：1997-04-01 00:00:00
abstract：PURPOSE:Little is known of how children seek health information. This study evaluates online health information (OHI) seeking behaviours in adolescents undergoing major elective surgical procedures and compares responses within parent-child dyads. METHODS:With institutional approval, we prospectively surveyed parents ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04592-0
更新日期：2020-02-01 00:00:00
abstract：:Desmoplastic small round cell tumour (DSRCT) is an extremely rare neoplasm. Adolescent males and young adults are most frequently affected. It is highly malignant, with only 29% of patients surviving up to 3 years. This paper documents two cases, one of which, at 4 years old, is the second youngest case documented. Ca...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1401-1
更新日期：2005-04-01 00:00:00
abstract：:The aim of this study was to compare the safety and benefits of Soave's and Duhamel's pull-through procedures for the management of Hirschsprung's disease (HD). The patients consisted of 33 boys (85%) and six girls (15%), a ratio of 5.5:1. Their ages ranged from 1 day to 8 years. Rectal biopsy was performed to confirm...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1237-0
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Sacrococcygeal teratoma (SCT) is a rare childhood malignancy. Although overall survival is favorable, recurrent tumors are associated with poor outcomes. As most recurrences occur within 3 years of presentation, the utility of long-term surveillance is uncertain. METHODS:Patients with SCTs evaluated and man...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4132-1
更新日期：2017-11-01 00:00:00
abstract：:Pediatric vascular injuries are increasing in frequency and represent a challenging problem in pediatric surgical practice. Increased survival of low birth weight infants and advances in invasive diagnostic procedures have resulted in a dramatic increase in the number of these injuries. Formation of pseudoaneurysm of ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1238-z
更新日期：2004-08-01 00:00:00
abstract：:To evaluate the efficacy of ultrasound (US) guided percutaneous sclerotherapy in the pediatric population, 14 hydatid liver cysts (HLC) in eight male patients whose ages ranged between 6 and 16 years (mean 9.9 years) were treated. The maximum diameter was 110 mm. Albendazole was administered orally to all patients for...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000356
更新日期：2000-01-01 00:00:00
abstract：:Port-site recurrence (PSR) following laparoscopic procedures has been an unpredictable complication in adult cancer patients; however, no data exist about this phenomenon in the pediatric field. The aim of this study was to determine whether PSR, following endosurgical procedure for malignancies, is a typical complica...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0918-9
更新日期：2003-05-01 00:00:00
abstract：:A small phallus causes great concern regarding genital adequacy. A concealed penis, although of normal size, appears small either because it is buried in prepubic tissues, enclosed in scrotal tissue penis palmatus (PP), or trapped due to phimosis or a scar following circumcision or trauma. From July 1978 to January 20...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0770-y
更新日期：2002-12-01 00:00:00
abstract：:A boy with a history of esophageal atresia repair received an esophagoesophagostomy at 14 months for a severe refractory anastomotic stricture, which had already required repeated balloon dilation with intralesional dexamethasone injection. Anastomotic leakage and stricture was again evident after the second surgery, ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2367-1
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:The pathophysiology of Hirschsprung's disease (HSCR) is not entirely understood. There is no clear explanation for the occurrence of the spastic or tonically contracted aganglionic segment of bowel. Kv11.1 (hERG) channels play a critical role in the regulation of the resting membrane potential as well as affect...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3807-8
更新日期：2016-01-01 00:00:00
abstract：:The Malone antegrade enema (MACE) and the caecostomy button (CB) are two methods of achieving colonic lavage in constipated children with faecal soiling. We reviewed our experience with the MACE and CB, aiming to compare results, complications, and outcomes. Between June 1998 and August 2002, 37 children (15 boys) und...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1220-9
更新日期：2004-07-01 00:00:00
abstract：:Eighty-three gastric transpositions for oesophageal replacement were carried out over the 15-year period 1981-1995. The vast majority of patients underwent the replacement procedure for oesophageal atresia (OA) (56), 35 following failed or abandoned attempts at primary anastomosis, and 21 for isolated atresia. Caustic...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00178420
更新日期：1996-04-01 00:00:00
