当前位置： SCI文献检索 > LEUKEMIA期刊下所有文献 > MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias.

MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias.

Abstract：

:Retroviral insertional mutagenesis in BXH2 mice commonly induces myeloid leukemias. One of the most frequently involved genes in experimental studies is Meis 1. In contrast to other genes in murine models, Meis 1 has not been affected by recurrent chromosomal translocations or point mutations in human leukemias. We found a constant downregulation of the Meis 1 gene mRNA in AML1-ETO acute myeloid leukemias and in those cases harboring in frame mutations in the bZIP domain of CEBPalpha. The absence of the Meis 1 mRNA was not caused by inactivating point mutations in the coding sequence. Promoter hypermethylation was present in more than half of the cases (9/14), including samples obtained from the widely employed Kasumi-1 cell line. Double treatment with 5-Aza-2'-deoxycytidine and trichostatin A of the Kasumi-1 cell line partially reverses Meis 1 inhibition. HoxA9 levels were also low. In a cell line model (U937 Tet AML1-ETO), AML1-ETO expression was not associated with Meis 1 suppression at 72 h. Nevertheless, Meis 1 repression is dependent on the AML1-ETO transcript levels in treated leukemic patients. Chimeric products that arise from chromosomal translocations may be associated with locus-specific epigenetic inactivation. It remains to be investigated when this methylation process is acquired and which are the basic mechanisms underlying these molecular events in AML1-ETO and CEBPalpha-mutated AML.

journal_name

Leukemia

journal_title

Leukemia

authors

Lasa A,Carnicer MJ,Aventín A,Estivill C,Brunet S,Sierra J,Nomdedéu JF

doi

10.1038/sj.leu.2403377

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

1231-7

issue

7

eissn

0887-6924

issn

1476-5551

pii

2403377

journal_volume

18

pub_type

杂志文章

相关文献

LEUKEMIA文献大全
  • Examination of a role for idiotypy in the disease remission of a long-term survivor of adult T cell leukemia treated with anti-Tac antibody.

    abstract：:The alpha chain of the interleukin 2 receptor (IL2R alpha; Tac) was targeted in clinical trials with adult T cell leukemia using murine anti-Tac antibody. Of 19 patients, a single individual achieved a durable complete remission. The mechanism of this action by murine anti-Tac has not been defined. We examined the hyp...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2401048

    authors： Kingsbury GA,Waldmann TA,Junghans RP

    更新日期：1998-06-01 00:00:00

  • A novel CD10-positive erythroid cell line, RM10, established from a patient with chronic myelogenous leukemia.

    abstract：:A novel erythroid cell line, RM10, was established from a long-term bone marrow culture of a patient with chronic myelogenous leukemia (CML). RM10 cells were positive for periodic acid Schiff (PAS), but negative for peroxidase and dual esterase. RM10 cells had la, pre B (CD10), myeloid (CD13, CD14, CD33) and erythroid...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Hirata J,Sato H,Takahira H,Shiokawa S,Endo T,Nishimura J,Katsuno M,Masuda S,Sasaki R,Fukumaki Y

    更新日期：1990-05-01 00:00:00

  • Monitoring of minimal residual disease (MRD) by real-time quantitative reverse transcription PCR (RQ-RT-PCR) in childhood acute myeloid leukemia with AML1/ETO rearrangement.

    abstract：:The fusion transcript AML1/ETO corresponding to translocation t(8;21)(q22;q22) can be found in approximately 7-12% of childhood de novo AML. Despite the favorable prognosis, some of these patients relapse. Most of MRD studies so far were performed on adults treated not uniformly. Therefore, we analyzed the follow-up o...

    journal_title：Leukemia

    pub_type： 杂志文章,多中心研究

    doi：10.1038/sj.leu.2402959

    authors： Viehmann S,Teigler-Schlegel A,Bruch J,Langebrake C,Reinhardt D,Harbott J

    更新日期：2003-06-01 00:00:00

  • Molecular investigation of the cytokines produced by normal and malignant B lymphocytes.

    abstract：:Different normal and malignant human B-cell populations were studied with a twofold aim: to define which cytokines are produced in vivo, and to assess the relationship between cytokine production and kinetic state. To analyse normal B-cells representative of different stages of activation and proliferation in vivo, we...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Schena M,Gaidano G,Gottardi D,Malavasi F,Larsson LG,Nilsson K,Caligaris-Cappio F

    更新日期：1992-02-01 00:00:00

  • The oncogenicity of Jun.

    abstract：:A mutational analysis of the delta region of the Jun protein shows an inverse correlation between transforming and transactivation potential of the mutant proteins if both properties are measured in chicken embryo fibroblasts. The possibility that Jun acquires oncogenicity not by gain but by loss of function is also s...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Vogt PK,Morgan IM,Håvarstein L,Su H,Hartl M,Schuur E

    更新日期：1992-01-01 00:00:00

  • YAC clone H10 discriminates between 3q26.2 and 3q27 chromosome rearrangements in hematological disorders.

    abstract：:To discriminate with molecular-cytogenetic resolution between 3q26.2 breakpoint, associated to various myeloproliferative disorders, and 3q27 breakpoint, recurrent in several types of non-Hodgkin lymphoma, we tested the feasibility of using a yeast artificial chromosome, YAC clone H10, mapped on 3q26.3. Fluorescent in...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Temperani P,Gandini G,Volinia S,Giacobbi F,Vaccari P,Waterfield MD,Emilia G

    更新日期：1996-02-01 00:00:00

  • Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report.

    abstract：:Infants <1 year of age have a high prevalence of prognostically unfavorable leukemias and a presumed susceptibility to treatment-related toxicities. A total of 125 infants with acute myeloid leukemia (AML) were treated in studies AML-BFM-98 (n = 59) and -2004 (n = 66). Treatment regimens of both studies were comparabl...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2011.267

    authors： Creutzig U,Zimmermann M,Bourquin JP,Dworzak MN,Kremens B,Lehrnbecher T,von Neuhoff C,Sander A,von Stackelberg A,Schmid I,Starý J,Steinbach D,Vormoor J,Reinhardt D

    更新日期：2012-04-01 00:00:00

  • CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia.

    abstract：:Upregulation of the immunosuppressive cell surface glycoprotein, CD200, is a common feature of acute myeloid leukemia (AML) and is associated with poor patient outcome. We investigated whether CD200 overexpression on AML cells could specifically compromise patient natural killer (NK) cell anti-tumor responses. We foun...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2011.1

    authors： Coles SJ,Wang EC,Man S,Hills RK,Burnett AK,Tonks A,Darley RL

    更新日期：2011-05-01 00:00:00

  • Cancer procoagulant in the human promyelocytic cell line NB4 and its modulation by all-trans-retinoic acid.

    abstract：:Acute promyelocytic leukemia (APL) cells express different types of procoagulant activity (PCA), including tissue factor (TF), and cancer procoagulant (CP). The aim of this study was to investigate whether the NB4 cell line, the first ever isolated human APL line, with the typical t(15;17) chromosomal balance transloc...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Falanga A,Consonni R,Marchetti M,Mielicki WP,Rambaldi A,Lanotte M,Gordon SG,Barbui T

    更新日期：1994-01-01 00:00:00

  • P-glycoprotein expression as unfavorable prognostic factor in acute myeloid leukemia.

    abstract：:In order to further define the role of the MDR1 gene in acute myeloid leukemia (AML), we determined the association between the presence of P-glycoprotein on leukemic cells and the efficacy of therapy in patients with AML. Immunocytochemistry with monoclonal antibody C219 was performed to demonstrate the presence of P...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Zöchbauer S,Gsur A,Brunner R,Kyrle PA,Lechner K,Pirker R

    更新日期：1994-06-01 00:00:00

  • Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome.

    abstract：:Mutations of the GATA1 gene on chromosome X have been found in almost all cases of transient myeloproliferative disorder and acute megakaryoblastic leukemia (AMKL) accompanying Down syndrome (DS). Although most GATA1 mutations lead to the expression of GATA1s lacking the N-terminal activation domain, we recently found...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2404223

    authors： Xu G,Kanezaki R,Toki T,Watanabe S,Takahashi Y,Terui K,Kitabayashi I,Ito E

    更新日期：2006-06-01 00:00:00

  • Potential antileukemic effect of gamma delta T cells in acute lymphoblastic leukemia.

    abstract：:The immune response to leukemia is poorly understood. We postulated that nonmalignant T lymphocytes remaining within bone marrow from children with newly diagnosed ALL could be involved in this immune response. T lymphocytes which expressed gamma delta TCR comprised less than 1% of ALL marrow cells. A preferential out...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Duval M,Yotnda P,Bensussan A,Oudhiri N,Guidal C,Rohrlich P,Boumsell L,Grandchamp B,Vilmer E

    更新日期：1995-05-01 00:00:00

  • Role of curcumin and the inhibition of NF-kappaB in the onset of chemotherapy-induced mucosal barrier injury.

    abstract：:The inhibition of nuclear factor kappa B (NF-kappaB) by, for instance, curcumin is becoming an important new approach in combination with chemotherapy or irradiation for the treatment of a variety of cancers including haematological malignancies. A dose-limiting side effect of anticancer therapy in the gastrointestina...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2403233

    authors： van't Land B,Blijlevens NM,Marteijn J,Timal S,Donnelly JP,de Witte TJ,M'Rabet L

    更新日期：2004-02-01 00:00:00

  • Detection of p53 mutations in B cell non-Hodgkin's lymphoma cell lines.

    abstract：:The p53 tumor suppressor gene is frequently mutated within its evolutionarily conserved regions in a number of human cancers. Previous reports demonstrated mutations of this gene in both Burkitt's lymphoma and B cell chronic lymphocytic leukemia. However, dissimilar results were obtained in non-Hodgkin's lymphoma (NHL...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Li CC,O'Connell CD,Beckwith M,Longo DL

    更新日期：1995-04-01 00:00:00

  • High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma.

    abstract：:Mantle cell lymphoma (MCL) is a moderately aggressive B-cell lymphoma that responds poorly to currently used therapeutic protocols. In order to identify tumour characteristics that improve the understanding of biology of MCL, analysis of oligonucleotide microarrays were used to define specific gene expression profiles...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2403057

    authors： Islam TC,Asplund AC,Lindvall JM,Nygren L,Liden J,Kimby E,Christensson B,Smith CI,Sander B

    更新日期：2003-09-01 00:00:00

  • Human stem cell factor (c-kit ligand) induces an autocrine loop of growth in a GM-CSF-dependent megakaryocytic leukemia cell line.

    abstract：:The M07e megakaryoblastic leukemia cell line is strictly dependent on either interleukin 3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF) for continuous growth. This study shows that recombinant human stem-cell factor (rhSCF) can completely replace these lymphokines in supporting the continued pro...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Kiss C,Cesano A,Zsebö KM,Clark SC,Santoli D

    更新日期：1993-02-01 00:00:00

  • Cryptic insertion and translocation or nondividing leukemic cells disclosed by FISH analysis in infant acute leukemia with discrepant molecular and cytogenetic findings.

    abstract：:Of 51 infants with acute leukemia, 13 (25%) had contradictory findings on 11q23/MLL rearrangements that were analyzed by cytogenetic and Southern blot methods: seven had rearranged MLL and normal karyotype, four had rearranged MLL and abnormal karyotype with no 11q23 translocation, and two had germline MLL and 11q23 t...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2402900

    authors： Watanabe N,Kobayashi H,Ichiji O,Yoshida MA,Kikuta A,Komada Y,Sekine I,Ishida Y,Horiukoshi Y,Tsunematsu Y,Yano M,Nakadate H,Kaneko Y

    更新日期：2003-05-01 00:00:00

  • Long-term outcome of autologous transplantation of peripheral blood progenitor cells as postremission management of adult acute myelogenous leukemia in first complete remission.

    abstract：:In order to improve leukemia-free survival (LFS) without the treatment-related morbidity of allogeneic bone marrow transplantation or multiple prolonged cycles of consolidation chemotherapy, we evaluated the long-term outcome of autologous transplantation of peripheral blood progenitor cells (PBPCs) as postremission t...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2403126

    authors： Collisson EA,Lashkari A,Malone R,Paquette R,Emmanouilides C,Territo MC,Schiller GJ

    更新日期：2003-11-01 00:00:00

  • Perillyl alcohol selectively induces G0/G1 arrest and apoptosis in Bcr/Abl-transformed myeloid cell lines.

    abstract：:The Bcr/Abl tyrosine kinase that is expressed from the Philadelphia chromosome protects leukemia cells from apoptosis caused by removal of growth factors or by cytotoxic agents and ionizing irradiation. This resistance to apoptosis is associated with a Bcr/Abl-mediated G2/M delay. Therefore, inhibiting Bcr/Abl signali...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2401536

    authors： Sahin MB,Perman SM,Jenkins G,Clark SS

    更新日期：1999-10-01 00:00:00

  • Natural killer-cell malignancies: diagnosis and treatment.

    abstract：:Natural killer (NK)-cell malignancies are uncommon diseases. Previously known as polymorphic reticulosis or angiocentric T-cell lymphomas, they are classified by the World Health Organization as NK/T-cell lymphoma, nasal type and aggressive NK-cell leukemia. They are prevalent in Asia and South America, but exceptiona...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：10.1038/sj.leu.2403955

    authors： Kwong YL

    更新日期：2005-12-01 00:00:00

  • Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity.

    abstract：:Identification of agents that target human leukemia stem cells is an important consideration for the development of new therapies. The present study demonstrates that rocaglamide and silvestrol, closely related natural products from the flavagline class of compounds, are able to preferentially kill functionally define...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2014.93

    authors： Callahan KP,Minhajuddin M,Corbett C,Lagadinou ED,Rossi RM,Grose V,Balys MM,Pan L,Jacob S,Frontier A,Grever MR,Lucas DM,Kinghorn AD,Liesveld JL,Becker MW,Jordan CT

    更新日期：2014-10-01 00:00:00

  • Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron.

    abstract：:Perturbation in iron homeostasis is a hallmark of some hematologic diseases. Abnormal sideroblasts with accumulation of iron in the mitochondria are named ring sideroblasts (RS). RS is a cardinal feature of refractory anemia with RS (RARS) and RARS with marked thrombocytosis (RARS/-T). Mutations in SF3B1, a member of ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2014.170

    authors： Visconte V,Avishai N,Mahfouz R,Tabarroki A,Cowen J,Sharghi-Moshtaghin R,Hitomi M,Rogers HJ,Hasrouni E,Phillips J,Sekeres MA,Heuer AH,Saunthararajah Y,Barnard J,Tiu RV

    更新日期：2015-01-01 00:00:00

  • Characterization of immunoglobulin heavy chain genes from an acute lymphocytic leukemia with four rearrangements.

    abstract：:Approximately 25% of acute leukemias of the B-cell lineage demonstrate more than two rearranged immunoglobulin heavy chain genes when examined by Southern blot analysis. The origin of the extra bands was investigated by molecular cloning and sequencing of four rearranged genes from one patient's leukemic cells. All fo...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Carter M,Neale GA,Kitchingman GR

    更新日期：1991-08-01 00:00:00

  • Molecular variants of the 1;19 chromosomal translocation in pediatric acute lymphoblastic leukemia (ALL).

    abstract：:The t(1;19)(q23;p13), a non-random chromosome rearrangement associated with childhood pre-B acute lymphoblastic leukemia (ALL), results at molecular level in the hybrid E2A-PBX1 gene. This gene is expressed in a typical set of fusion transcripts and oncogenic chimeric proteins. However, the occurrence of t(1;19) molec...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Privitera E,Luciano A,Ronchetti D,Aricò M,Santostasi T,Basso G,Biondi A

    更新日期：1994-04-01 00:00:00

  • Clinical significance of CD81 expression by clonal plasma cells in high-risk smoldering and symptomatic multiple myeloma patients.

    abstract：:The presence of CD19 in myelomatous plasma cells (MM-PCs) correlates with adverse prognosis in multiple myeloma (MM). Although CD19 expression is upregulated by CD81, this marker has been poorly investigated and its prognostic value in MM remains unknown. We have analyzed CD81 expression by multiparameter flow cytomet...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2012.42

    authors： Paiva B,Gutiérrez NC,Chen X,Vídriales MB,Montalbán MÁ,Rosiñol L,Oriol A,Martínez-López J,Mateos MV,López-Corral L,Díaz-Rodríguez E,Pérez JJ,Fernández-Redondo E,de Arriba F,Palomera L,Bengoechea E,Terol MJ,de Paz R,Mar

    更新日期：2012-08-01 00:00:00

  • Cell-free transmission of Fv-4 resistance gene product controlling Friend leukemia virus-induced leukemogenesis in mice.

    abstract：:Fv-4 is a mouse gene that dominantly confers resistance to infection by ecotropic murine leukemia virus (MuLV). The Fv-4' env antigen that binds to the cell surface of Fv-4'-bearing C3H cells was found in sera from normal Fv-4'-bearing C4W mice. The serum Fv-4' env antigen binds to ecotropic MuLV receptors, shown by s...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Kitagawa M,Aizawa S,Ikeda H,Hirokawa K

    更新日期：1997-04-01 00:00:00

  • Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97.

    abstract：:In this study, the long-term outcome of 1818 patients treated in five consecutive clinical trials (the cooperative study group for childhood acute lymphoblastic leukaemia (COALL) 82, 85, 89, 92 and 97) from 24 cooperating centres in Germany is reported. The probability of event-free survival (pEFS) improved significan...

    journal_title：Leukemia

    pub_type： 临床试验,杂志文章

    doi：10.1038/leu.2009.249

    authors： Escherich G,Horstmann MA,Zimmermann M,Janka-Schaub GE,COALL study group.

    更新日期：2010-02-01 00:00:00

  • To be or not to be a T-lymphomas, that is determined by a dominant gene Tlsm-1 in mouse models.

    abstract：:A single dominant gene Tlsm-1 was found to determine the type of spontaneous lymphomas to be T in the cross between AKR/Ms and SL/Kh. Microsatellite analysis mapped Tlsm-1 at the position 61 cM from centromere of Chr. 7. Study of this segment of T-lymphoma prone AKXD Rl strains also showed association of Tlsm-1 with T...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Hiai H,Yamada Y,Shisa H,Kamoto T,Abujiang P,Lu LM

    更新日期：1997-04-01 00:00:00

  • Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Leukemia

    pub_type： 已发布勘误

    doi：10.1038/s41375-020-0968-9

    authors： Prutsch N,Gurnhofer E,Suske T,Liang HC,Schlederer M,Roos S,Wu LC,Simonitsch-Klupp I,Alvarez-Hernandez A,Kornauth C,Leone DA,Svinka J,Eferl R,Limberger T,Aufinger A,Shirsath N,Wolf P,Hielscher T,Sternberg C,Aberger F

    更新日期：2020-11-01 00:00:00

  • A hypothesis for the pathogenesis of myelodysplastic syndromes: implications for new therapies.

    abstract：:To guide development of new clinical strategies, a review of recent investigations in the pathobiology of MDS was performed. Articles were identified through a Medline search. Studies, including reviews, are cited in the references. A multistep pathogenesis is proposed. (1) Targeted injury or mutation within hemopoiet...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：10.1038/sj.leu.2401618

    authors： Rosenfeld C,List A

    更新日期：2000-01-01 00:00:00