The succinate dehydrogenase inhibition test for evaluating biopsy specimens and resected tumors of advanced gastric cancer.

Abstract:

:An in vitro chemosensitivity study of both biopsy specimens and surgically resected tumors of advanced gastric cancer from 12 patients was evaluated using the succinate dehydrogenase inhibition (SDI) test. A decrease in succinate dehydrogenase (SD) activity as an indicator of chemosensitivity was determined using cisplatin (CDDP), etoposide (VP-16), and mitomycin C (MMC). In this study, 29 of a total 36 experiments were evaluable (80.6%) and significant correlations were found in all three of the antitumor drugs (P < 0.03). This finding suggests that the SDI test using biopsy specimens may prove valuable for assessing the preoperative chemosensitivity of advanced gastric cancer.

journal_name

Surg Today

journal_title

Surgery today

authors

Kimura H,Yonemura Y,Ohyama S,Tsugawa K,Kinoshita K,Ninomiya I,Kosaka T,Miwa K,Miyazaki I,Tanaka M

doi

10.1007/BF00308895

subject

Has Abstract,Author List Incomplete

pub_date

1992-01-01 00:00:00

pages

508-11

issue

6

eissn

0941-1291

issn

1436-2813

journal_volume

22

pub_type

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