Abstract:
PURPOSE:We investigated the expression of cyclooxygenase (Cox-1 and Cox-2) in mammary tissues from patients with breast cancer. METHODS:We used reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry. RESULTS:The cancer cells showed very weak expression of Cox-1, but strong expression of immunoreactive Cox-2. In contrast, immunoreactive Cox-2 was very weak in all of the benign mammary tumors examined, including fibroadenoma (FA) and mastopathy (MP). Immunoreactive Cox-1 was also very weak in these benign tumors. The extent and intensity of immunoreactive Cox-2 polypeptides was significantly greater in the cancer cells than in the FA cells or MP cells. RT-PCR analysis showed enhanced expression of Cox-2, but not Cox-1 in breast cancer tissue, and faint expression of Cox-2 in benign tissue. CONCLUSIONS:These results demonstrated that human breast cancer cells generated Cox-2, indicating that Cox-2 might play an important role in the proliferation of breast cancer cells.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Yoshimura N,Sano H,Okamoto M,Akioka K,Ushigome H,Kadotani Y,Yoshimura R,Nobori S,Higuchi A,Ohmori Y,Nakamura Kdoi
10.1007/s00595-003-2606-3subject
Has Abstractpub_date
2003-01-01 00:00:00pages
805-11issue
11eissn
0941-1291issn
1436-2813journal_volume
33pub_type
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