Abstract:
:Calcium channels in neurons mediate a wide variety of essential functions. In addition to contributing to action potential shape, they furnish a substrate that acts as an intracellular second messenger. This study shows that the shape of the neuronal action potential has characteristics that promote long openings of L-type (high threshold) calcium channels. We also present evidence that a change in the firing rate of isolated neurons modulates gating of single calcium channels. This mechanism could be important in modulating neuron excitability and providing a rise in intracellular Ca, when needed.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Mazzanti M,Galli A,Ferroni Adoi
10.1016/S0006-3495(92)81669-7subject
Has Abstractpub_date
1992-10-01 00:00:00pages
926-34issue
4eissn
0006-3495issn
1542-0086pii
S0006-3495(92)81669-7journal_volume
63pub_type
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