The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation.

abstract：:IRE1-alpha is an integral membrane protein of the endoplasmic reticulum (ER) that is a key sensor in the cellular transcriptional response to stress in the ER. Upon induction of ER stress, IRE1-alpha is activated, resulting in the synthesis of the active form of the transcription factor XBP1 via IRE1-mediated splicing...

journal_title：Molecular and cellular biology

authors： Huang ZM,Tan T,Yoshida H,Mori K,Ma Y,Yen TS

更新日期：2005-09-01 00:00:00

abstract：:hsa-miR-33a and hsa-miR-33b, intronic microRNAs (miRNAs) located within the sterol regulatory element-binding protein 2 and 1 genes (Srebp-2 and -1), respectively, have recently been shown to regulate lipid homeostasis in concert with their host genes. Although the functional role of miR-33a and -b has been highly inv...

journal_title：Molecular and cellular biology

authors： Goedeke L,Vales-Lara FM,Fenstermaker M,Cirera-Salinas D,Chamorro-Jorganes A,Ramírez CM,Mattison JA,de Cabo R,Suárez Y,Fernández-Hernando C

更新日期：2013-06-01 00:00:00

abstract：:Introduction of simian virus 40 T antigen into rodent fibroblasts gives rise to cells that can proliferate indefinitely but are dependent upon it for maintenance of their growth once the normal mitotic life span has elapsed. Inactivation of T antigen in these immortalized cells causes rapid and irreversible cessation ...

journal_title：Molecular and cellular biology

authors： Gonos ES,Burns JS,Mazars GR,Kobrna A,Riley TE,Barnett SC,Zafarana G,Ludwig RL,Ikram Z,Powell AJ,Jat PS

更新日期：1996-09-01 00:00:00

abstract：:Fms is the receptor for macrophage colony-stimulating factor (M-CSF) and contains intrinsic tyrosine kinase activity. Expression of exogenous Fms in a murine myeloid progenitor cell line, FDC-P1 (FD-Fms), results in M-CSF-dependent growth and macrophage differentiation. Previously, we described a 100-kDa protein that ...

journal_title：Molecular and cellular biology

authors： Liu Y,Jenkins B,Shin JL,Rohrschneider LR

更新日期：2001-05-01 00:00:00

abstract：:Histone N-terminal tails are central to the processes that modulate nucleosome structure and function. We have studied the contribution of core histone tails to the structure of a single nucleosome and to a histone (H3-H4)(2) tetrameric particle assembled on a topologically constrained DNA minicircle. The effect of hi...

journal_title：Molecular and cellular biology

authors： Morales V,Richard-Foy H

更新日期：2000-10-01 00:00:00

abstract：:Activation of peroxisome proliferator-activated receptor alpha (PPARalpha) leads to hepatocellular proliferation and liver carcinomas. The early events mediating these effects are unknown. A novel mechanism by which PPARalpha regulates gene expression and hepatocellular proliferation was uncovered. MicroRNA (miRNA) ex...

journal_title：Molecular and cellular biology

authors： Shah YM,Morimura K,Yang Q,Tanabe T,Takagi M,Gonzalez FJ

更新日期：2007-06-01 00:00:00

abstract：:The TIS11 primary response gene is rapidly and transiently induced by both 12-O-tetradecanoylphorbol-13-acetate and growth factors. The predicted TIS11 protein contains a 6-amino-acid repeat, YKTELC. We cloned two additional cDNAs, TIS11b and TIS11d, that contain the YKTELC sequence. TIS11, TIS11b, and TIS11d proteins...

journal_title：Molecular and cellular biology

authors： Varnum BC,Ma QF,Chi TH,Fletcher B,Herschman HR

更新日期：1991-03-01 00:00:00

abstract：:GATA-3 is a zinc finger transcription factor which is expressed in a highly restricted and strongly conserved tissue distribution pattern in vertebrate organisms, specifically, in a subset of hematopoietic cells, in cells within the central and peripheral nervous systems, in the kidney, and in placental trophoblasts. ...

journal_title：Molecular and cellular biology

authors： Yang Z,Gu L,Romeo PH,Bories D,Motohashi H,Yamamoto M,Engel JD

更新日期：1994-03-01 00:00:00

abstract：:We examined the mechanisms that control the downregulation of the c-myc mRNA during differentiation of HL60 cells. On treatment with dimethyl sulfoxide, HL60 cells downmodulated their steady-state c-myc message levels, ceased to proliferate, and underwent terminal differentiation. In nuclear run-on assays in which dis...

journal_title：Molecular and cellular biology

authors： Siebenlist U,Bressler P,Kelly K

更新日期：1988-02-01 00:00:00

abstract：:Telomere maintenance is required for chromosome stability, and telomeres are typically replicated by the action of the reverse transcriptase telomerase. In both tumor and yeast cells that lack telomerase, telomeres are maintained by an alternative recombination mechanism. Genetic studies have led to the identification...

journal_title：Molecular and cellular biology

authors： Tsai YL,Tseng SF,Chang SH,Lin CC,Teng SC

更新日期：2002-08-01 00:00:00

abstract：:ADAR2 is a double-stranded-RNA-specific adenosine deaminase involved in the editing of mammalian RNAs by the site-selective conversion of adenosine to inosine. Previous studies from our laboratory have demonstrated that ADAR2 can modify its own pre-mRNA to create a proximal 3' splice site containing a noncanonical ade...

journal_title：Molecular and cellular biology

authors： Feng Y,Sansam CL,Singh M,Emeson RB

更新日期：2006-01-01 00:00:00

abstract：:Adipocytes constitute a major part of the bone marrow stroma in vivo and may play an active role in lymphohematopoiesis. Earlier studies had shown that the bone marrow stromal cell clone BMS2 was capable of adipocyte differentiation in vitro, in addition to its well-defined ability to support B lymphopoiesis. We now d...

journal_title：Molecular and cellular biology

authors： Gimble JM,Dorheim MA,Cheng Q,Pekala P,Enerback S,Ellingsworth L,Kincade PW,Wang CS

更新日期：1989-11-01 00:00:00

abstract：:The Wnt/β-catenin signaling pathway plays crucial roles in early hindbrain formation, and its constitutive activity is associated with a subset of human medulloblastoma, a malignant childhood tumor of the posterior fossa. However, the precise function of Wnt/β-catenin signaling during cerebellar development is still e...

journal_title：Molecular and cellular biology

authors： Lorenz A,Deutschmann M,Ahlfeld J,Prix C,Koch A,Smits R,Fodde R,Kretzschmar HA,Schüller U

更新日期：2011-08-01 00:00:00

abstract：:The active 17S U2 small nuclear ribonucleoprotein particle (snRNP), which binds to the intron branch site during the formation of the prespliceosome, is assembled in vitro by sequential interactions of the essential splicing factors SF3b and SF3a with the 12S U2 snRNP. We have analyzed the function of individual subun...

journal_title：Molecular and cellular biology

authors： Nesic D,Krämer A

更新日期：2001-10-01 00:00:00

abstract：:We previously identified a sequence-specific erythroid cell-enriched endoribonuclease (ErEN) activity involved in the turnover of the stable alpha-globin mRNA. We now demonstrate that ErEN activity is regulated by the poly(A) tail. The unadenylated alpha-globin 3' untranslated region (3'UTR) was an efficient substrate...

journal_title：Molecular and cellular biology

authors： Wang Z,Kiledjian M

更新日期：2000-09-01 00:00:00

abstract：:We assayed phosphatidylinositol (PI) kinase (EC 2.7.1.67) activity in detergent extracts of nontransformed or virus-transformed cells. Nontransformed chicken embryo fibroblasts (CEF) contain PI kinase activity with an apparent specific activity of 20 pmol/min per mg of protein. This activity sedimented as a single pea...

journal_title：Molecular and cellular biology

authors： Sugano S,Hanafusa H

更新日期：1985-09-01 00:00:00

abstract：:Wnt/β-catenin signaling is a critical regulator of skeletal physiology. However, previous studies have mainly focused on its roles in osteoblasts, while its specific function in osteoclasts is unknown. This is a clinically important question because neutralizing antibodies against Wnt antagonists are promising new dru...

journal_title：Molecular and cellular biology

authors： Wei W,Zeve D,Suh JM,Wang X,Du Y,Zerwekh JE,Dechow PC,Graff JM,Wan Y

更新日期：2011-12-01 00:00:00

abstract：:SEC63 encodes a protein required for secretory protein translocation into the endoplasmic reticulum (ER) of Saccharomyces cerevisiae (J. A. Rothblatt, R. J. Deshaies, S. L. Sanders, G. Daum, and R. Schekman, J. Cell Biol. 109:2641-2652, 1989). Antibody directed against a recombinant form of the protein detects a 73-kD...

journal_title：Molecular and cellular biology

authors： Feldheim D,Rothblatt J,Schekman R

更新日期：1992-07-01 00:00:00

abstract：:TFIID is a multiprotein complex consisting of the TATA box binding protein and multiple tightly associated proteins (TAFIIs) that are required for transcription by selected activators. We previously reported cloning and partial characterization of human TAFII130 (hTAFII130). The central domain of hTAFII130 contains fo...

journal_title：Molecular and cellular biology

authors： Saluja D,Vassallo MF,Tanese N

更新日期：1998-10-01 00:00:00

abstract：:The upstream activating sequence of the adjacent and divergently transcribed GAL1 and GAL10 genes of Saccharomyces cerevisiae (UASG) contains at least three distinct classes of overlapping transcriptional control sites. The transcription activator GAL4 binds to four related sites in UASG and induces expression of GAL1...

journal_title：Molecular and cellular biology

authors： Finley RL Jr,West RW Jr

更新日期：1989-10-01 00:00:00

abstract：:Nearly 40% of cases of acute myelogenous leukemia (AML) of the M2 subtype are due to a chromosomal translocation that combines a sequence-specific DNA binding protein, AML1, with a potent transcriptional repressor, ETO. ETO interacts with nuclear receptor corepressors SMRT and N-CoR, which recruit histone deacetylase ...

journal_title：Molecular and cellular biology

authors： Zhang J,Hug BA,Huang EY,Chen CW,Gelmetti V,Maccarana M,Minucci S,Pelicci PG,Lazar MA

更新日期：2001-01-01 00:00:00

abstract：:Barsoum and Varshavsky (Proc. Natl. Acad. Sci. U.S.A. 80:5330-5334, 1983) suggest that polypeptide mitogens and the mitogenic tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulate gene amplification by related pathways. I demonstrated that TPA and the polypeptide mitogen fibroblast growth factor (FGF) bo...

journal_title：Molecular and cellular biology

authors： Herschman HR

更新日期：1985-05-01 00:00:00

abstract：:The progression of spermatogenesis involves global changes in chromatin structure and conformation. However, our understanding of the regulation of chromatin changes in germ cells remains limited. Here we describe both in vivo RNA interference and genetic mouse knockout studies that identify a critical role for Yin Ya...

journal_title：Molecular and cellular biology

authors： Wu S,Hu YC,Liu H,Shi Y

更新日期：2009-12-01 00:00:00

abstract：:A 249-nucleotide coding region instability determinant (CRD) destabilizes c-myc mRNA. Previous experiments identified a CRD-binding protein (CRD-BP) that appears to protect the CRD from endonuclease cleavage. However, it was unclear why a CRD-BP is required to protect a well-translated mRNA whose coding region is cove...

journal_title：Molecular and cellular biology

authors： Lemm I,Ross J

更新日期：2002-06-01 00:00:00

abstract：:Exposure of monocytic cells to bacterial lipopolysaccharide (LPS) activates the NF-kappa B/Rel family of proteins and leads to the rapid induction of inflammatory gene products, including tissue factor (TF). TF is the primary cellular initiator of the coagulation protease cascades. Here we report the characterization ...

journal_title：Molecular and cellular biology

authors： Oeth PA,Parry GC,Kunsch C,Nantermet P,Rosen CA,Mackman N

更新日期：1994-06-01 00:00:00

abstract：:The baker's yeast Saccharomyces cerevisiae expresses three homologues of the Nramp family of metal transporters: Smf1p, Smf2p, and Smf3p, encoded by SMF1, SMF2, and SMF3, respectively. Here we report a comparative analysis of the yeast Smf proteins at the levels of localization, regulation, and function of the corresp...

journal_title：Molecular and cellular biology

authors： Portnoy ME,Liu XF,Culotta VC

更新日期：2000-11-01 00:00:00

abstract：:Interleukin-6 (IL-6) is one of the major mediators of inflammation, and its expression is inducible by the other inflammatory lymphokines, interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). We demonstrate that a common IL-6 promoter element, termed inflammatory lymphokine-responsive element (ILRE), is i...

journal_title：Molecular and cellular biology

authors： Shimizu H,Mitomo K,Watanabe T,Okamoto S,Yamamoto K

更新日期：1990-02-01 00:00:00

abstract：:NIH3T3 cells transformed by mouse Int-2/Fgf-3 cDNA express a series of Int-2-related products representing discrete stages of processing and glycosylation. We confirm that in at least two highly transformed clonal lines, Int-2 products acquire further modifications and are efficiently secreted into the culture medium....

journal_title：Molecular and cellular biology

authors： Kiefer P,Peters G,Dickson C

更新日期：1991-12-01 00:00:00

abstract：:Ubiquitin is a multifunctional 76-amino-acid protein which plays critical roles in many aspects of cellular metabolism. In Caenorhabditis elegans, the major source of ubiquitin RNA is the polyubiquitin locus, UbiA. UbiA is transcribed as a polycistronic mRNA which contains 11 tandem repeats of ubiquitin sequence and p...

journal_title：Molecular and cellular biology

authors： Graham RW,Jones D,Candido EP

更新日期：1989-01-01 00:00:00

abstract：:Skp2B, an F-box protein of unknown function, is frequently overexpressed in breast cancer. In order to determine the function of Skp2B and whether it has a role in breast cancer, we performed a two-hybrid screen and established transgenic mice expressing Skp2B in the mammary glands. We found that Skp2B interacts with ...

journal_title：Molecular and cellular biology

authors： Umanskaya K,Radke S,Chander H,Monardo R,Xu X,Pan ZQ,O'Connell MJ,Germain D

更新日期：2007-11-01 00:00:00