Abstract:
:Major depressive disorder (MDD) is a serious illness with far reaching societal and economic ramifications. The monoamine-deficiency hypothesis that depressive symptoms are associated with reductions in monoamine neurotransmission, particularly serotonin and noradrenaline, is supported by both neurochemical findings and the successful treatment of MDD with compounds that enhance monoaminergic neurotransmission. This review focuses on novel compounds in different stages of development for the treatment of MDD that enhance monoaminergic neurotransmission via a number of different mechanisms, including re-uptake inhibition of one or more monoamines, monoamine oxidase inhibitors, the combination of monoamine antagonists with re-uptake inhibitors and monoamine receptor subtype agonists. Compounds that enhance individual monoamines have antidepressant properties and compounds that enhance multiple monoamines appear to have a synergistic antidepressant effect and potentially faster onset of action. The differing mechanisms of action possessed by these novel monoamine-enhancing compounds will offer greater treatment flexibility in the therapeutic management of MDD.
journal_name
Expert Opin Investig Drugsjournal_title
Expert opinion on investigational drugsauthors
Bymaster FP,McNamara RK,Tran PVdoi
10.1517/13543784.12.4.531subject
Has Abstractpub_date
2003-04-01 00:00:00pages
531-43issue
4eissn
1354-3784issn
1744-7658journal_volume
12pub_type
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
pub_type: 杂志文章,评审
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abstract:IMPORTANCE OF THE FIELD:Migraine is an episodic, substantially inherited brain disorder affecting 15% of adults in Western Europe and North America, and is one of the commonest reasons for patients to see their physicians. While the World Health Organization considers that severe migraine can be as disabling as quadrip...
journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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更新日期:2000-03-01 00:00:00
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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更新日期:2016-06-01 00:00:00
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journal_title:Expert opinion on investigational drugs
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更新日期:2002-04-01 00:00:00
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journal_title:Expert opinion on investigational drugs
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abstract::Standard drug therapy of adult polymyositis, dermatomyositis and inclusion body myositis includes high-dose corticosteroids and cytotoxic drugs (methotrexate, azathioprine (AZA) and cyclophosphamide). Recent data are in favour of the early introduction of a cytotoxic or immunomodulating drug in addition to corticoster...
journal_title:Expert opinion on investigational drugs
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更新日期:2001-07-01 00:00:00
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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abstract::The topics discussed at this conference covered many aspects of the pathogenesis, epidemiology, diagnosis and treatment of rheumatic diseases, from the search of new therapeutic targets and evaluation of new diagnostic techniques to preclinical and clinical development of novel therapies. This contribution focuses pri...
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journal_title:Expert opinion on investigational drugs
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journal_title:Expert opinion on investigational drugs
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