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Telomere dynamics in childhood leukemia and solid tumors: a follow-up study.

Abstract：

:Telomeres of hematopoietic cells shorten with age, possibly contributing to the aging-associated hematopoietic pathology (immunosenescence, malignant transformation). Accelerated telomere shortening is seen with replicative stress, such as during administration of serial chemotherapy cycles for the treatment of childhood cancer. To define the long-term consequences of pediatric cancer treatment on hematopoietic cell telomere length, we undertook a prospective 4-year follow-up study of a 61-patient cohort of pediatric malignancies in a community-based setting. We found that mononuclear cells (MNC) and granulocytes of children with standard-risk acute lymphoblastic leukemia (ALL) suffered minimal telomere shortening throughout therapy (less than 1 kbp; average follow-up, 20 months), while those of children with solid tumors showed greater and more heterogenous telomere attrition (0.5-2.8 kbp, average follow-up, 9 months). In addition, we evaluated the role of telomerase, the enzyme commonly up-regulated in pediatric leukemic and solid tumor cells for telomere length maintenance, as a disease marker. Serial determinations of telomerase in MNC were useful to confirm disease remission in leukemia, but play no role in the follow-up of children with solid tumors.

journal_name

Leukemia

journal_title

Leukemia

authors

Franco S,Ozkaynak MF,Sandoval C,Tugal O,Jayabose S,Engelhardt M,Moore MA

doi

10.1038/sj.leu.2402815

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

401-10

issue

2

eissn

0887-6924

issn

1476-5551

pii

2402815

journal_volume

17

pub_type

杂志文章

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