Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis.

abstract：:The expression of c-ets2 is rapidly induced in a variety of myelomonocytic cell lines as they differentiate into macrophages. We find that constitutive expression of c-ets2 in the M1D+ myeloblast leukemic cell line (M1ets2) is sufficient to push these cells to a more differentiated state. The expression of several dif...

journal_title：Molecular and cellular biology

authors： Aperlo C,Pognonec P,Stanley ER,Boulukos KE

更新日期：1996-12-01 00:00:00

abstract：:Circadian clock genes are regulated through a transcriptional-translational feedback loop. Alterations of the chromatin structure by histone acetyltransferases and histone deacetylases (HDACs) are commonly implicated in the regulation of gene transcription. However, little is known about the transcriptional regulation...

journal_title：Molecular and cellular biology

authors： Naruse Y,Oh-hashi K,Iijima N,Naruse M,Yoshioka H,Tanaka M

更新日期：2004-07-01 00:00:00

abstract：:Alkylpurine-DNA-N-glycosylase (APNG) null mice have been generated by homologous recombination in embryonic stem cells. The null status of the animals was confirmed at the mRNA level by reverse transcription-PCR and by the inability of cell extracts of tissues from the knockout (ko) animals to release 3-methyladenine ...

journal_title：Molecular and cellular biology

authors： Elder RH,Jansen JG,Weeks RJ,Willington MA,Deans B,Watson AJ,Mynett KJ,Bailey JA,Cooper DP,Rafferty JA,Heeran MC,Wijnhoven SW,van Zeeland AA,Margison GP

更新日期：1998-10-01 00:00:00

abstract：:In eukaryotes, crossovers in mitotic cells can have deleterious consequences and therefore must be suppressed. Mutations in BLM give rise to Bloom syndrome, a disease that is characterized by an elevated rate of crossovers and increased cancer susceptibility. However, simple eukaryotes such as Saccharomyces cerevisiae...

journal_title：Molecular and cellular biology

authors： Hu Y,Lu X,Barnes E,Yan M,Lou H,Luo G

更新日期：2005-05-01 00:00:00

abstract：:The regulation of a thyroid hormone-responsive gene in rats, designated spot 14, was explored. The expression of this gene in liver is rapidly (less than 10 min) and markedly (greater than 10-fold) altered by the administration of 3,5,3'-triiodo-L-thyronine (T3) to hypothyroid rats (P. Narayan, C. W. Liaw, and H. C. T...

journal_title：Molecular and cellular biology

authors： Narayan P,Towle HC

更新日期：1985-10-01 00:00:00

abstract：:An enzyme that hydrolyzes one PPi bond of the cap structure of mRNA, yielding m7GDP and 5'-p RNA was purified from Saccharomyces cerevisiae to a stage suitable for characterization. The specificity of the enzyme was studied, using both yeast mRNA and synthetic RNAs labeled in the cap structure. A synthetic capped RNA ...

journal_title：Molecular and cellular biology

authors： Stevens A

更新日期：1988-05-01 00:00:00

abstract：:The myeloperoxidase (MPO) and neutrophil elastase genes are expressed specifically in immature myeloid cells. The integrity of a polyomavirus enhancer core sequence, 5'-AACCACA-3', is critical to the activity of the murine MPO proximal enhancer. This element binds two species, myeloid nuclear factors 1 alpha and 1 bet...

journal_title：Molecular and cellular biology

authors： Nuchprayoon I,Meyers S,Scott LM,Suzow J,Hiebert S,Friedman AD

更新日期：1994-08-01 00:00:00

abstract：:First characterized in Trypanosoma brucei, the spliced leader-associated (SLA) RNA gene locus has now been isolated from the kinetoplastids Leishmania tarentolae and Trypanosoma cruzi. In addition to the T. brucei SLA RNA, both L. tarentolae and T. cruzi SLA RNA repeat units also yield RNAs of 75 or 76 nucleotides (nt...

journal_title：Molecular and cellular biology

authors： Roberts TG,Sturm NR,Yee BK,Yu MC,Hartshorne T,Agabian N,Campbell DA

更新日期：1998-08-01 00:00:00

abstract：:The 3' noncoding region element (AUUUA)n specifically targets many short-lived mRNAs for degradation. Although the mechanism by which this sequence functions is not yet understood, a potential link between facilitated mRNA turnover and translation has been implied by the stabilization of cellular mRNAs in the presence...

journal_title：Molecular and cellular biology

authors： Aharon T,Schneider RJ

更新日期：1993-03-01 00:00:00

abstract：:Cells of Candida albicans WO-1 spontaneously switch between a white and opaque CFU, and this phase transition involves a dramatic change in cellular phenotype. By using a differential hybridization screen, an opaque-specific cDNA, Op1a, which represents the transcript of a gene regulated by switching, has been isolate...

journal_title：Molecular and cellular biology

authors： Morrow B,Srikantha T,Soll DR

更新日期：1992-07-01 00:00:00

abstract：:Nuclear respiratory-defective mutants of Saccharomyces cerevisiae have been screened for lesions in the mitochondrial alpha-ketoglutarate dehydrogenase complex. Strains assigned to complementation group G70 were ascertained to be deficient in enzyme activity due to mutations in the KGD1 gene coding for the alpha-ketog...

journal_title：Molecular and cellular biology

authors： Repetto B,Tzagoloff A

更新日期：1989-06-01 00:00:00

abstract：:Using an in vitro binding-site selection assay, we have demonstrated that c-Myc-Max complexes bind not only to canonical CACGTG or CATGTG motifs that are flanked by variable sequences but also to noncanonical sites that consist of an internal CG or TG dinucleotide in the context of particular variations in the CA--TG ...

journal_title：Molecular and cellular biology

authors： Blackwell TK,Huang J,Ma A,Kretzner L,Alt FW,Eisenman RN,Weintraub H

更新日期：1993-09-01 00:00:00

abstract：:The Son of sevenless proteins (Sos) are guanine nucleotide exchange factors involved in the activation of Ras by cytoplasmic and receptor tyrosine kinases. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Previous studies have demonstrated that growth factor-...

journal_title：Molecular and cellular biology

authors： Corbalan-Garcia S,Yang SS,Degenhardt KR,Bar-Sagi D

更新日期：1996-10-01 00:00:00

abstract：:Adiponectin is a secretory protein abundantly secreted from adipocytes. It assembles into a number of different higher-order complexes. Adipocytes maintain tight control over circulating plasma levels, suggesting the existence of a complex, highly regulated biosynthetic pathway. However, the critical mediators of adip...

journal_title：Molecular and cellular biology

authors： Wang ZV,Schraw TD,Kim JY,Khan T,Rajala MW,Follenzi A,Scherer PE

更新日期：2007-05-01 00:00:00

abstract：:Imprinting of the linked and oppositely expressed mouse H19 and Igf2 genes requires a 2-kb differentially methylated domain (DMD) that is located 2 kb upstream of H19. This element is postulated to function as a methylation-sensitive insulator. Here we test whether an additional sequence 5' of H19 is required for H19 ...

journal_title：Molecular and cellular biology

authors： Thorvaldsen JL,Mann MR,Nwoko O,Duran KL,Bartolomei MS

更新日期：2002-04-01 00:00:00

abstract：:LAC9 is a DNA-binding protein that regulates transcription of the lactose-galactose regulon in Kluyveromyces lactis. The DNA-binding domain is composed of a zinc finger and nearby amino acids (M. M. Witte and R. C. Dickson, Mol. Cell. Biol. 8:3726-3733, 1988). The single zinc finger appears to be structurally related ...

journal_title：Molecular and cellular biology

authors： Witte MM,Dickson RC

更新日期：1990-10-01 00:00:00

abstract：:The signal transducer and activator of transcription STAT5 plays a major role in the cellular response to cytokines, but the mechanism by which it activates transcription remains poorly understood. We show here that deacetylase inhibitors (trichostatin A, suberoylanilide hydroxamic acid, and sodium butyrate) prevent i...

journal_title：Molecular and cellular biology

authors： Rascle A,Johnston JA,Amati B

更新日期：2003-06-01 00:00:00

abstract：:Three subtypes of retinoic acid receptors (RAR), termed RAR alpha, RAR beta, and RAR gamma, have been described. They are composed of different structural domains, including distinct domains for DNA and ligand binding. RARs specifically bind all-trans-retinoic acid (RA), 9-cis-RA, and retinoid analogs. In this study, ...

journal_title：Molecular and cellular biology

authors： Lamour FP,Lardelli P,Apfel CM

更新日期：1996-10-01 00:00:00

abstract：:The liver-enriched transcription factor C/EBP alpha has been implicated in the regulation of numerous liver-specific genes. It was previously reported that mice carrying a homozygous null mutation at the c/ebp alpha locus died as neonates due to the absence of hepatic glycogen and the resulting hypoglycemia. However, ...

journal_title：Molecular and cellular biology

authors： Lee YH,Sauer B,Johnson PF,Gonzalez FJ

更新日期：1997-10-01 00:00:00

abstract：:Compromised immunoregulation contributes to obesity and complications in metabolic pathogenesis. Here, we demonstrate that the nuclear factor of activated T cell (NFAT) group of transcription factors contributes to glucose and insulin homeostasis. Expression of two members of the NFAT family (NFATc2 and NFATc4) is ind...

journal_title：Molecular and cellular biology

authors： Yang TT,Suk HY,Yang X,Olabisi O,Yu RY,Durand J,Jelicks LA,Kim JY,Scherer PE,Wang Y,Feng Y,Rossetti L,Graef IA,Crabtree GR,Chow CW

更新日期：2006-10-01 00:00:00

abstract：:Using a subtractive cloning scheme on cDNA prepared from primary pro-B and pre-B cells, we identified several genes whose products regulate apoptosis. We further characterized one of these genes, encoding protein kinase Ceta (PKCeta). PKCeta transcripts were readily detected in pro-B cells but were absent in pre-B cel...

journal_title：Molecular and cellular biology

authors： Morrow TA,Muljo SA,Zhang J,Hardwick JM,Schlissel MS

更新日期：1999-08-01 00:00:00

abstract：:The expression of the c-jun proto-oncogene is rapidly induced in response to mitogens acting on a large variety of cell surface receptors. The resulting functional activity of c-Jun proteins appears to be critical for cell proliferation. Recently, we have shown that a large family of G protein-coupled receptors (GPCRs...

journal_title：Molecular and cellular biology

authors： Marinissen MJ,Chiariello M,Pallante M,Gutkind JS

更新日期：1999-06-01 00:00:00

abstract：:The 3' AU-rich region of human beta-1 interferon (hu-IFN beta) mRNA was found to act as a translational inhibitory element. The translational regulation of this 3' AU-rich sequence and the effect of its association with the poly(A) tail were studied in cell-free rabbit reticulocyte lysate. A poly(A)-rich hu-IFN beta m...

journal_title：Molecular and cellular biology

authors： Grafi G,Sela I,Galili G

更新日期：1993-06-01 00:00:00

abstract：:We isolated cDNA clones corresponding to the normal human Ki-ras2 gene and to the transforming allele of the Ki-ras2 gene present in the human colon carcinoma cell line SW480. These two cDNAs encode p21 proteins which differ only at the amino acid at position 12. The normal cDNA encodes a glycine at this position, and...

journal_title：Molecular and cellular biology

authors： McCoy MS,Bargmann CI,Weinberg RA

更新日期：1984-08-01 00:00:00

abstract：:Tax1, a potent activator of human T-cell lymphotropic virus type 1 (HTLV-1) transcription, has been shown to modulate expression of many cellular genes. Tax1 does not bind DNA directly but regulates transcription through protein-protein interactions with sequence-specific transcription factors. Using the yeast two-hyb...

journal_title：Molecular and cellular biology

authors： Pise-Masison CA,Dittmer J,Clemens KE,Brady JN

更新日期：1997-03-01 00:00:00

abstract：:Eukaryotic genomes are divided into independent transcriptional domains by DNA elements known as insulators. The gypsy insulator, a 350-bp element isolated from the Drosophila gypsy retrovirus, contains twelve degenerate binding sites for the Suppressor of Hairy-wing [Su(Hw)] protein. Su(Hw) associates with over 500 n...

journal_title：Molecular and cellular biology

authors： Parnell TJ,Kuhn EJ,Gilmore BL,Helou C,Wold MS,Geyer PK

更新日期：2006-08-01 00:00:00

abstract：:Human antigen R (ELAVL1; HuR) is perhaps the best-characterized RNA-binding protein. Through its overexpression in various tumor types, HuR promotes posttranscriptional regulation of target genes in multiple core signaling pathways associated with tumor progression. The role of HuR overexpression in pancreatic tumorig...

journal_title：Molecular and cellular biology

authors： Peng W,Furuuchi N,Aslanukova L,Huang YH,Brown SZ,Jiang W,Addya S,Vishwakarma V,Peters E,Brody JR,Dixon DA,Sawicki JA

更新日期：2018-01-16 00:00:00

abstract：:Box C/D snoRNPs, factors essential for ribosome biogenesis, are proposed to be assembled in the nucleoplasm before localizing to the nucleolus. However, recent work demonstrated the involvement of nuclear export factors in this process, suggesting that export may take place. Here we show that there are distinct distri...

journal_title：Molecular and cellular biology

authors： Watkins NJ,Lemm I,Lührmann R

更新日期：2007-10-01 00:00:00

abstract：:The intracellular accumulation of the unspliced RNA of Rous sarcoma virus was decreased when translation was prematurely terminated by the introduction of nonsense codons within its 5' proximal gene, the gag gene. Subcellular fractionation of transfected cells suggested that nonsense codon-mediated instability occurre...

journal_title：Molecular and cellular biology

authors： Barker GF,Beemon K

更新日期：1994-03-01 00:00:00

abstract：:The immunoglobulin M heavy-chain locus contains two poly(A) sites which are alternatively expressed during B-cell differentiation. Despite its promoter proximal location, the secretory poly(A) site is not expressed in undifferentiated cells. Crucial to the activation of the secretory poly(A) site during B-cell differe...

journal_title：Molecular and cellular biology

authors： Phillips C,Pachikara N,Gunderson SI

更新日期：2004-07-01 00:00:00