Abstract:
:A case with transient, almost complete sleep loss caused by cerebral manifestation of Whipple's disease (WD) is presented. Cerebral WD is rare and in most cases occurs after gastrointestinal infection. In our case, a progressive and finally almost complete sleep loss was the initial and predominant symptom. Polysomnographic studies in several consecutive nights and over 24 h showed a total abolition of the sleep-wake cycle with nocturnal sleep duration of less than 15 min. Endocrine tests revealed hypothalamic dysfunction with flattening of circadian rhythmicity of cortisol, TSH, growth hormone and melatonin. Cerebrospinal fluid (CSF) hypocretin was reduced. [18F]Deoxyglucose positron emission tomography (FDG-PET) revealed hypermetabolic areas in cortical and subcortical areas including the brainstem, which might explain sleep pathology and vertical gaze palsy. In the course of treatment with antibiotics and additional carbamazepine for 1 year, insomnia slowly and gradually improved. Endocrine investigations at 1-year follow-up showed persistent flattening of circadian rhythmicity. The FDG-PET indicated normalized metabolism in distinct regions of the brain stem which paralleled restoration of sleep length. The extent of sleep disruption in this case of organic insomnia was similar to cases of familial fatal insomnia, but was at least partially reversible with treatment.
journal_name
J Sleep Resjournal_title
Journal of sleep researchauthors
Voderholzer U,Riemann D,Gann H,Hornyak M,Juengling F,Schumacher M,Reincke M,Von Herbay A,Nishino S,Mignot E,Berger M,Lieb Kdoi
10.1046/j.1365-2869.2002.00311.xsubject
Has Abstractpub_date
2002-12-01 00:00:00pages
321-9issue
4eissn
0962-1105issn
1365-2869pii
311journal_volume
11pub_type
杂志文章abstract::We previously described a strong concordance between nocturnal oscillations in plasma renin activity (PRA) and the rapid eye movement (REM) and non-REM (NREM) sleep cycles, but the mechanisms inducing PRA oscillations remain to be identified. This study was designed to examine whether they are linked to sleep stage-re...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1046/j.1365-2869.2002.00277.x
更新日期:2002-03-01 00:00:00
abstract::The aim of this study was to investigate the association between patterns of jaw motor activity during sleep and clinical signs and symptoms of sleep bruxism. A total of 35 university students and staff members participated in this study after providing informed consent. All participants were divided into either a sle...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12481
更新日期:2017-08-01 00:00:00
abstract::The pathophysiological processes of Alzheimer's dementia predate its clinical manifestation. Sleep disturbances can accelerate the aging process and are common features of dementia. This study examined whether quantitative sleep electroencephalogram changes predate the clinical development of mild cognitive impairment...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12666
更新日期:2019-06-01 00:00:00
abstract::Actigraphy is a cost-efficient method to estimate sleep-wake patterns over long periods in natural settings. However, the lack of methodological standards in actigraphy research complicates the generalization of outcomes. A rapidly growing methodological diversity is visible in the field, which increasingly necessitat...
journal_title:Journal of sleep research
pub_type: 杂志文章,评审
doi:10.1111/jsr.13134
更新日期:2020-07-08 00:00:00
abstract::This study aimed to explore the association between restless legs syndrome and irritable bowel syndrome in an epidemiological cohort. We included 3365 adults, of whom 1602 were female (age 52.5 ± 7.5 years), who had participated in the Korean Genome and Epidemiology Study (2005-2006). The diagnosis of restless legs sy...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2012.01011.x
更新日期:2012-10-01 00:00:00
abstract::Sleep is severely impaired in patients with Alzheimer's disease. Amyloid-β deposition in the brain of Alzheimer's disease patients is a key event in its pathogenesis and is associated with disrupted sleep, even before the appearance of cognitive decline. Because soluble amyloid-β oligomers are the key mediators of syn...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13187
更新日期:2020-09-09 00:00:00
abstract::Current evidence suggests that elevations in blood pressure during obstructive apnoeic episodes increase pharyngeal collapsibility and the severity of obstructive sleep apnoea. ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1995.tb00193.x
更新日期:1995-06-01 00:00:00
abstract::The objective of this study was to examine which genetic and environmental influences contribute to individual differences in sleep duration in a sample of Croatian adolescent/early adult twins, as well as to investigate the relationship between personality and sleep duration. Participants included 339 twin pairs (105...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12101
更新日期:2014-04-01 00:00:00
abstract::Parents of children with special healthcare needs (CSHCNs) report poorer sleep than parents of typically developing (TD) children, which has been associated with poorer mental health. The relations between sleep disturbances and general health and memory among this population are unknown. The current study aimed to re...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12329
更新日期:2016-02-01 00:00:00
abstract::The aim of this work was to study the effects of bright light-induced circadian phase shifts on sleep propensity and sleep architecture while the timing of the sleep/wake cycle is kept constant. Twenty-three normal subjects underwent an 11-day study including: (i) baseline sleep and vigilance evaluation; (ii) baseline...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1995.tb00171.x
更新日期:1995-12-01 00:00:00
abstract::Little is known about the potential impacts of wind turbine noise (WTN) on sleep. Previous research is limited to cross-sectional studies reporting anecdotal impacts on sleep using inconsistent sleep metrics. This meta-analysis sought to comprehensively review studies evaluating the impact of WTN using widely accepted...
journal_title:Journal of sleep research
pub_type: 杂志文章,评审
doi:10.1111/jsr.13228
更新日期:2020-11-12 00:00:00
abstract::Neural systems of the prefrontal cortex (PFC) involved in executive functions are particularly vulnerable to sleep deprivation (SD). In this study, we investigated whether SD selectively affects specific components of the executive control processes involved in task-switching performance. Two different tasks are perfo...
journal_title:Journal of sleep research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2869.2009.00774.x
更新日期:2010-03-01 00:00:00
abstract::Primary insomnia is a prevalent sleep disorder affecting approximately 3% of the general population. Studies suggest that personality traits such as perfectionism and neuroticism might be implicated in the aetiology of the disorder. However, to date, no study has investigated behavioural indicators of these factors in...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2011.00970.x
更新日期:2012-06-01 00:00:00
abstract::Epidemiologic studies have shown that sleep duration is associated with overall mortality. We conducted a systematic review of the associations between sleep duration and all-cause and cause-specific mortality. PubMed was systematically searched up to January, 2008 to identify studies examining the association between...
journal_title:Journal of sleep research
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1365-2869.2008.00732.x
更新日期:2009-06-01 00:00:00
abstract::In modern society, people often fail to obtain the amount of sleep that experts recommend for good health and performance. Insufficient sleep can lead to degraded cognitive performance and alterations in emotional functioning. However, most people also acknowledge that on a regular basis they obtain more sleep than th...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12056
更新日期:2013-10-01 00:00:00
abstract::Previous cross-sectional studies regarding the association of restless legs syndrome (RLS) with cardiovascular morbidity are controversial. Our aim was to evaluate prospectively the relationship of cardiovascular risk factors and vascular diseases with incident RLS in the general population. The results are from two p...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12040
更新日期:2013-08-01 00:00:00
abstract::Recently, evidence has emerged that the phases of the moon may modulate subjective sleep quality and polysomnographically assessed sleep structure in humans. We aimed to explore further the putative effects of circa-lunar periodicity (~29.5 days) on subjective and objective parameters of human sleep in a retrospective...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12312
更新日期:2015-12-01 00:00:00
abstract::Stimulus factors known to influence the amplitude of the well known endogenous event-related potential (ERP) component P300 were manipulated to determine whether they have the same, or a different, influence on the amplitude of positivities of the sleep ERPs identified as P220, P450, and P900. Behavioral responsivenes...
journal_title:Journal of sleep research
pub_type: 临床试验,杂志文章
doi:10.1046/j.1365-2869.2001.00238.x
更新日期:2001-03-01 00:00:00
abstract::Cardiac death is the second most prevalent cause in Prader-Willi syndrome (PWS). Paediatric patients with PWS often present cardiac autonomic dysfunction during wakefulness, obesity and sleep-disordered breathing. However, the extent of cardiac autonomic modulation during sleep in PWS has not been documented. The obje...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13165
更新日期:2020-08-18 00:00:00
abstract::It has been hypothesized that insufficient sleep may compromise neuronal function and contribute to neurodegenerative processes. While sleep loss by itself may not lead to cell death directly, it may affect the sensitivity to a subsequent neurodegenerative insult. Here we examined the effects of chronic sleep restrict...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2011.00932.x
更新日期:2012-02-01 00:00:00
abstract::Previous research has indicated that personality factors such as openness to experience, creativity, visual memory, attitude toward dreams, and sleep behavior is related to home dream recall frequency (DRF). However, a study investigating all areas simultaneously within one sample in order to determine the percentage ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1046/j.1365-2869.2003.00344.x
更新日期:2003-06-01 00:00:00
abstract::Depression is common in women with obstructive sleep apnea (OSA), but objective markers of depression have not yet been explored in such patients. We hypothesized that inflammation and antioxidant biomarkers may be associated with depression in a cohort of OSA women. We conducted a multicentre, cross-sectional study i...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13035
更新日期:2021-02-01 00:00:00
abstract::Intensive care unit (ICU) environment has a very strong and unavoidable negative impact on patients' sleep. Sleep deprivation in ICU patients has been already studied and negative effects on their outcome (prolonged ICU stay, decreased recovery) and complication rates (incidence of delirium, neuropsychological sequels...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12607
更新日期:2018-06-01 00:00:00
abstract::Rett syndrome is a rare neurodevelopmental disorder usually affecting females, and is associated with a mutation in the MECP2 gene. Sleep problems occur commonly and we investigated the trajectories and influences of age, mutation and treatments. Data were collected at six time points over 12 years from 320 families r...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12240
更新日期:2015-04-01 00:00:00
abstract::Decreases in heart rate variability, a marker of autonomic nervous system function, are associated with increased cardiovascular mortality. Heart rate variability increases in non-rapid eye movement sleep, peaking in slow-wave sleep. Therefore, decreasing the amount of deep sleep, for example, by introducing patients ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12560
更新日期:2018-04-01 00:00:00
abstract::The role of arousals in sleep is gaining interest among both basic researchers and clinicians. In the last 20 years increasing evidence shows that arousals are deeply involved in the pathophysiology of sleep disorders. The nature of arousals in sleep is still a matter of debate. According to the conceptual framework o...
journal_title:Journal of sleep research
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2869.2004.00388.x
更新日期:2004-03-01 00:00:00
abstract::The current definition of rapid eye movement (REM) sleep without atonia has no quantitative character, and cut-off values above which the level of electromyographic tone can be considered to be 'excessive' are unclear. The aim of this study was to analyse the characteristics of chin electromyographic amplitude by mean...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2011.00958.x
更新日期:2012-06-01 00:00:00
abstract::An accurate home sleep study to assess electroencephalography (EEG)-based sleep stages and EEG power would be advantageous for both clinical and research purposes, such as for longitudinal studies measuring changes in sleep stages over time. The purpose of this study was to compare sleep scoring of a single-channel EE...
journal_title:Journal of sleep research
pub_type: 临床试验,杂志文章
doi:10.1111/jsr.12417
更新日期:2016-12-01 00:00:00
abstract::Sleep deprivation has a variable impact on extrinsic activities during multiple cognitive tasks, especially on mood and emotion processing. There is also a trait-like individual vulnerability or compensatory effect in cognition. Previous studies have elucidated the altered functional connectivity after sleep deprivati...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12147
更新日期:2014-10-01 00:00:00
abstract::Sleep-disordered breathing is a common condition, related to a higher cardiometabolic and neurocognitive risk. The main risk factors for sleep-disordered breathing include obesity, craniofacial characteristics, male sex and age. However, some studies have suggested that adverse socioeconomic circumstances and lifestyl...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12799
更新日期:2019-10-01 00:00:00