Abstract：
:Costameres, structures at the plasma membrane of skeletal muscle, are present in a rectilinear array that parallels the organization of the underlying contractile apparatus. Costameres have three major functions: to keep the plasma membrane, or sarcolemma, aligned and in register with nearby contractile structures; to protect the sarcolemma against contraction-induced damage; and to transmit some of the forces of contraction laterally, to the extracellular matrix. These functions require that costameres link the contractile apparatus through the membrane to the extracellular matrix. Mutations to key components of costameres cause these structures to lose their rectilinear organization and can result in muscle weakness or death. This article summarizes the evidence that costameres are composed of large complexes of integral and peripheral membrane proteins that are linked to the contractile apparatus by intermediate filaments and to the extracellular matrix by laminin. They also present evidence that costameres are altered when key costameric components are missing, as in a murine form of muscular dystrophy.
journal_name
Clin Orthop Relat Resjournal_title
Clinical orthopaedics and related researchauthors
Bloch RJ,Capetanaki Y,O'Neill A,Reed P,Williams MW,Resneck WG,Porter NC,Ursitti JAdoi
10.1097/00003086-200210001-00024subject
Has Abstractpub_date
2002-10-01 00:00:00pages
S203-10issue
403 Suppleissn
0009-921Xissn
1528-1132pub_type
杂志文章,评审abstract：:The natural history of degenerative lumbar spinal stenosis is documented poorly. Little is known about the efficacy of nonoperative treatments. An aggressive nonoperative treatment consisting of therapeutic exercise, analgesics, and epidural steroid injections is proposed. The clinical evaluation of the patients is re...
journal_title：Clinical orthopaedics and related research
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journal_title：Clinical orthopaedics and related research
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journal_title：Clinical orthopaedics and related research
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journal_title：Clinical orthopaedics and related research
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更新日期：2003-06-01 00:00:00
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更新日期：2004-09-01 00:00:00
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更新日期：1977-03-01 00:00:00
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更新日期：1993-09-01 00:00:00
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更新日期：2006-08-01 00:00:00
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更新日期：2011-01-01 00:00:00
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journal_title：Clinical orthopaedics and related research
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更新日期：1986-01-01 00:00:00
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journal_title：Clinical orthopaedics and related research
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更新日期：1983-01-01 00:00:00
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journal_title：Clinical orthopaedics and related research
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journal_title：Clinical orthopaedics and related research
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更新日期：1990-08-01 00:00:00
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abstract：UNLABELLED:Recently, medial patellofemoral ligament reconstruction has been emphasized for the treatment of patellar dislocation. This study compared the results of medial patellofemoral ligament reconstruction by adductor magnus tenodesis with distal patellar realignment in patients with recurrent patellar dislocation...
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journal_title：Clinical orthopaedics and related research
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更新日期：1992-11-01 00:00:00
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journal_title：Clinical orthopaedics and related research
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journal_title：Clinical orthopaedics and related research
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更新日期：1994-10-01 00:00:00
