Functional properties of knee ligaments and alterations induced by immobilization: a correlative biomechanical and histological study in primates.

Abstract:

:The effect of immobility on the biomechanical properties of an anterior cruciate bone-ligament-bone unit of rhesus monkey is reported. Wild primates were used and the captivity time was minimized to lessen disuse changes from cage confinement. The ligament-bone specimens were tested in tension to failure under high strain-rate conditions. After 8-weeks total-body plaster immobilization of the primate, the ligament units showed significant decreases in maximum failure load and energy absorbed to failure (39 per cent and 32 per cent respectively). A dramatic change in ligament load-elongation behavior occurred. There was a statistically significant decrease in stiffness (slope of the load-deformation curve) of the ligament unit which may also be expressed as an increase in ligament compliance (elongation per unit load). The change in mechanical properties following immobility indicated a significant alteration in the projected functional capacity of the ligament unit to resist loading and to resist elongation; factors which relate directly to the ligament's ability to provide joint stability. The mechanisms of failure of the ligament unit, where an increase in osseous avulsion fractures occurred after immobilization correlated with histological changes of bone resorption in the cortex immediately beneath the ligament insertion site. Ultimate failure occurred in many, but not in all specimens, through the weakened bone. This emphasizes the potential for such effects in clinical conditions characterized by reduced bone mass. Alterations in the strength of the cortical bone may affect the integrity of ligament units as a whole. The effect of immobility on ligament units about the knee depended on histological characteristics of the ligament-bone attachment. The anterior cruciate ligament-bond junction, through zones of fibrocartilage, was little affected. In contrast, the tibial insertion of the superficial tibial collateral ligament, directely into bone in relation to the periosteum without well-defined zones of catilage, showed marked interruption after immobility due to bone resorption in the subperiosteal and outer cortical regions. In places the ligament was attached only to the overlying periosteum. In a second and third group of animals, the long-term effects of disuse were investigated. After 5 months' resumed activity following total-body-immobilization, there was only partial recovery in ligament strength although ligament stiffness and compliance parameters had returned to control values. It required up to 12 months for the complete recovery of ligament strength parameters.

journal_name

Clin Orthop Relat Res

authors

Noyes FR

subject

Has Abstract

pub_date

1977-03-01 00:00:00

pages

210-42

issue

123

eissn

0009-921X

issn

1528-1132

pub_type

杂志文章
  • Ultrastructural morphology of early cellular changes in the synovium of primary synovial chondromatosis.

    abstract::Synovial tissues taken from 13 cases of synovial chondromatosis (SC) were examined by light and electron microscopy. In three of the 13 cases, early cellular changes were observed by electron microscopy. Most of the foci were independently situated within an accumulation of fine, homogenous chondroid matrix in the sub...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Leu JZ,Matsubara T,Hirohata K

    更新日期:1992-03-01 00:00:00

  • Secondary tethers after physeal bar resection: a common source of failure?

    abstract::Despite a standardized operative technique and appropriate patient selection for physeal bar resection, a bar size less than 50% of the physis, and a prospective growth period greater than 2 years, failure may result. Limited growth because of poor function of the remaining physis and secondary tethers (incomplete res...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/00003086-200212000-00031

    authors: Hasler CC,Foster BK

    更新日期:2002-12-01 00:00:00

  • Treatment of Paget's disease of bone with ethane-1, hydroxy-1,1 diphosphonate (EHDP) at a low dosage (5 mg/kg/day).

    abstract::Paget's disease of bone in 51 patients was treated with ethane-1, hydroxy-1,1 diphosphonate (EHDP) for six months at a dosage of 5 mg/kg/day. Clinically, the analgesic effect on bone pain is clear, with parallel reduction in radioisotope uptake observed by quantitative bone scintigraphy. There is also a reduction of a...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Alexandre CM,Chapuy MC,Vignon E,Edouard C,Johnston CC,Meunier PJ

    更新日期:1983-04-01 00:00:00

  • Temporal variations in a modified Neer impingement test can confound clinical interpretation.

    abstract::High variability in the time required for patients to have substantial pain relief after Neer-type subacromial impingement tests might help explain conflicting data regarding their effectiveness in guiding treatment and predicting surgical outcomes. To focus on quantifying temporal variability associated with a modifi...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/BLO.0b013e31804a8581

    authors: Skedros JG,Pitts TC

    更新日期:2007-07-01 00:00:00

  • A genetic approach to the diagnosis of skeletal dysplasia.

    abstract::The skeletal dysplasias are a large and heterogeneous group of disorders. Currently, there are more than 100 recognized forms of skeletal dysplasia, which makes arriving at a specific diagnosis difficult. This process is additionally complicated by the rarity of the individual conditions. The establishment of a precis...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/00003086-200208000-00006

    authors: Unger S

    更新日期:2002-08-01 00:00:00

  • Bony entrapment of the superficial peroneal nerve.

    abstract::Peripheral nerve injury occasionally results from long bone fractures, but bony entrapment of a peripheral nerve occurs infrequently. Bony entrapment of a peripheral nerve is usually associated with upper extremity fractures. In a 34-year-old man bony entrapment of the superficial peroneal nerve occurred in a healed m...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Mino DE,Hughes EC Jr

    更新日期:1984-05-01 00:00:00

  • Constant direct-current treatment for established nonunion of the tibia.

    abstract::The treatment of nonunion of the tibia in 40 patients by constant direct current was evaluated in a prospective survey. The method was simple to apply and the complication rate was low, but considerable cooperation is required on the part of patients. The success rate was 85%. When two patients who had significant fra...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Heppenstall RB

    更新日期:1983-09-01 00:00:00

  • Juxtaphyseal aneurysmal bone cysts.

    abstract::Aneurysmal bone cysts are benign primary or secondary lesions that commonly arise in long bones and often before skeletal maturity. Little has been written about aneurysmal bone cysts that abut the physeal plate. The records of 15 patients with juxtaphyseal aneurysmal bone cysts were reviewed. Fourteen of the patients...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/00003086-199907000-00026

    authors: Rizzo M,Dellaero DT,Harrelson JM,Scully SP

    更新日期:1999-07-01 00:00:00

  • Effects of design changes on cemented tapered femoral stem fixation.

    abstract::The effects of matte finish and modularity on loosening of tapered stems using the same cementing technique were studied prospectively. In 80 patients, 82 cemented Exeter primary stems were implanted at total hip revision by one surgeon using the same surgical and cementing technique throughout the series. The polishe...

    journal_title:Clinical orthopaedics and related research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003086-199810000-00006

    authors: Middleton RG,Howie DW,Costi K,Sharpe P

    更新日期:1998-10-01 00:00:00

  • Anterior only fusion for scoliosis in patients with myelomeningocele.

    abstract::A series of patients with single major scoliosis curvatures attributable to spina bifida treated by anterior only spinal fusion was studied for 2 years to determine whether the infection rate could be decreased, adequate correction and pelvic balance could be provided, and posterior surgery could be avoided in these p...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/00003086-199907000-00016

    authors: Sponseller PD,Young AT,Sarwark JF,Lim R

    更新日期:1999-07-01 00:00:00

  • Functional outcome after hip fracture in Japan.

    abstract::One thousand one hundred sixty-nine elderly Japanese patients who sustained a hip fracture were observed prospectively. Ninety-two percent had operative fracture treatment. Hospital length of stay averaged 67 days; 81% of patients were discharged to their place of residence where they resided before sustaining the fra...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Kitamura S,Hasegawa Y,Suzuki S,Sasaki R,Iwata H,Wingstrand H,Thorngren KG

    更新日期:1998-03-01 00:00:00

  • Total knee replacement outcome and coexisting physical and emotional illness.

    abstract::Despite widespread acceptance of total knee replacement surgery's clinical effectiveness, variation persists in long-term functional outcome. Our aim was to quantify the relative contributions of physical and emotional coexisting conditions to the variation in improvement in 12-month post-total knee replacement physic...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/01.blo.0000185447.43622.93

    authors: Ayers DC,Franklin PD,Ploutz-Snyder R,Boisvert CB

    更新日期:2005-11-01 00:00:00

  • Cemented all polyethylene tibial components in patients age 75 years and older.

    abstract::Between 1976 and 1980, 81 knees in 59 patients 75 years of age or older, underwent primary total knee arthroplasty with a cemented, condylar femoral component and a cemented, moderately conforming, all polyethylene tibial component. All patients were followed up until death, revision surgery, or for a minimum of 10 ye...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Pagnano MW,Levy BA,Berry DJ

    更新日期:1999-10-01 00:00:00

  • Does the Proportion of Women in Orthopaedic Leadership Roles Reflect the Gender Composition of Specialty Societies?

    abstract:BACKGROUND:Increasing the number of women in surgical subspecialties has been challenging, especially in orthopaedics, in which the percentage of women has remained relatively the same for the past several decades. Certain subspecialties, such as pediatric orthopaedics, have a greater proportion of women than other ort...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/CORR.0000000000000823

    authors: Saxena S,Cannada LK,Weiss JM

    更新日期:2020-07-01 00:00:00

  • Recurrent Legg - Calve - Perthes' disease. A case report.

    abstract::This is a report of the fifth known case of recurrent Legg--Calve--Perthes' disease. Roentgenograms of the hips after the first avascular episode, at the age of 3 years and 6 months resemble to a certain extent, Dysplasia Epiphysealis Capitis Femoris. ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Axer A,Hendel D

    更新日期:1977-07-01 00:00:00

  • Longitudinal crack propagation in bone around femoral prosthesis.

    abstract::Intraoperative femoral fracture is a well-recognized technical complication of cementless total hip arthroplasty. This study was designed to establish an in vitro model for initiation and propagation of fractures of the proximal femur in cementless THA and to assess the effect of fracture fixation in the form of cercl...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Incavo SJ,DiFazio F,Wilder D,Howe JG,Pope M

    更新日期:1991-11-01 00:00:00

  • Arthroscopic treatment of the discoid lateral meniscus. Technique and long-term results.

    abstract::Forty-five patients (49 knees) who had torn complete or incomplete discoid lateral menisci were treated during the period from 1968 to 1980. Both instrumentation and specific techniques considerably evolved in the arthroscopic complete excision the torn discoid meniscus. The current technique involves the initial remo...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Ikeuchi H

    更新日期:1982-07-01 00:00:00

  • Stiffness and thickness of fascia do not explain chronic exertional compartment syndrome.

    abstract:BACKGROUND:Chronic exertional compartment syndrome is diagnosed based on symptoms and elevated intramuscular pressure and often is treated with fasciotomy. However, what contributes to the increased intramuscular pressure remains unknown. QUESTIONS/PURPOSES:We investigated whether the stiffness or thickness of the mus...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-011-2073-x

    authors: Dahl M,Hansen P,Stål P,Edmundsson D,Magnusson SP

    更新日期:2011-12-01 00:00:00

  • Two-stage operative treatment of comminuted os calcis fractures. Primary indirect reduction with medial external fixation and delayed lateral plate fixation.

    abstract::The indication for otherwise established lateral plate fixation in fractures of the calcaneus becomes relative when severe comminution (Sander's Type III and IV) of the bone involves concomitant massive soft-tissue swelling. The calcaneus is shortened, Böhler's angle flattened, and lateral bulging and varus deformity ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Baumgaertel FR,Gotzen L

    更新日期:1993-05-01 00:00:00

  • Arthroplasty using the Charnley prosthesis in old tuberculosis of the hip. Clinical experience with 8-10-year follow-up evaluation.

    abstract::Twenty patients with tuberculosis of the hip joint were treated by low-friction arthroplasty (LFA) and followed for eight to ten years. Five of the patients had reactivation of the infection and subsequent failure despite the use of chemotherapy. Successful revision arthroplasties have been performed on two of the fiv...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Kim YY,Ahn BH,Bae DK,Ko CU,Lee JD,Kwak BM,Yoon YS

    更新日期:1986-10-01 00:00:00

  • John Charnley Award: Randomized Clinical Trial of Direct Anterior and Miniposterior Approach THA: Which Provides Better Functional Recovery?

    abstract:BACKGROUND:The choice of surgical approach for THA remains controversial. Some studies suggest that the direct anterior approach (DAA) leads to less muscle damage than the miniposterior approach (MPA), but there is little high-quality evidence indicating whether this accelerates recovery, or whether this approach-which...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11999.0000000000000112

    authors: Taunton MJ,Trousdale RT,Sierra RJ,Kaufman K,Pagnano MW

    更新日期:2018-02-01 00:00:00

  • Lower cranial nerve palsies. Potentially lethal in association with upper cervical fracture-dislocations.

    abstract::Palsies of the lower cranial nerves occurred in association with traumatic atlantoaxial dissociations in two patients. The fracture-dislocations sustained were rare injuries and the neurologic complications contributed greatly to their morbidity and mortality. ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Hammer AJ

    更新日期:1991-05-01 00:00:00

  • Transcutaneous electrical neurostimulation: a new therapeutic modality for controlling pain.

    abstract::Transcutaneous electrical neurostimulation relieves chronic and acute pain by blocking the transmission of pain impulses with comfortable electrical stimulation of light touch sensation. The original Gate Control Theory of Melzack and Wall provides a working model to explain the significant pain relief afforded patien...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Ersek RA

    更新日期:1977-10-01 00:00:00

  • The distal arthrogryposes: a new classification of peripheral contractures.

    abstract::Distal arthrogryposes are a group of syndromes with congenital contractures primarily involving the hands and feet, which often are associated with abnormal facies, and are transmitted by autosomal dominant inheritance. Many affected individuals present in an orthopaedic setting. The features of these syndromes are de...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章,评审

    doi:

    authors: Beals RK

    更新日期:2005-06-01 00:00:00

  • Radiation exposure to an orthopedic surgeon.

    abstract::Occupational radiation exposure was measured using three film badges and one ring thermoluminescent dosimeter. The radiation dose in the hospital but outside the operating room was measured as zero for the 12-month period. The measured trunk dose in the operating room was 5 mrem, and the measured dose to the head and ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Barry TP

    更新日期:1984-01-01 00:00:00

  • Management of massive defects in radius and ulna following wringer injury. A case report.

    abstract::An unusual case of wringer injury in a 29-month-old child demonstrates extensive loss of the diaphysis of both the radius and ulna. Reconstruction consisted of cortico-cancellous autogenous tibial bone grafting of the radius and ulna in two stages. Follow-up of 24 years showed remodeling and good alignment of the enti...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Akbarnia BA,Campbell CJ,Bowen JR

    更新日期:1976-05-01 00:00:00

  • Periacetabular osteotomy: preoperative radiographic predictors of outcome.

    abstract::Periacetabular osteotomy is an extremely effective treatment for the spherical dysplastic hip without significant secondary osteoarthrosis. Yet, the reliability of the procedure in patients with some degree of secondary osteoarthritis, asphericity, or associated deformities remains undefined. The purpose of the curren...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章,评审

    doi:

    authors: Murphy S,Deshmukh R

    更新日期:2002-12-01 00:00:00

  • Hip fracture incidence in central norway: a followup study.

    abstract::Studies in the 1980s, including one from central Norway, in most cases showed that the incidence of hip fractures was increasing. In the 1990s, however, studies from Sweden and the United States indicated that the increase may have stopped. We report the current incidence of hip fractures in subjects in central Norway...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/00003086-200402000-00028

    authors: Finsen V,Johnsen LG,Tranø G,Hansen B,Sneve KS

    更新日期:2004-02-01 00:00:00

  • Spontaneous fractures in the renal graft recipient: a discriminant analysis of 144 cases.

    abstract::In a search for factors predisposing to the occurrence of spontaneous fractures in the renal organ transplant patient, a comparison has been made of 38 recipients sustaining spontaneous fractures and 106 without this complication. The comparison was made with regard to the clinical findings, the immunosuppressive ther...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Elmstedt E

    更新日期:1982-01-01 00:00:00

  • Total THA in adult osteonecrosis related to sickle cell disease.

    abstract:UNLABELLED:Most previous studies of THA in sickle cell disease report high risks of medical and orthopaedic complications, including infections and a higher incidence of failure than observed after THA for osteonecrosis related to other conditions. Based on our experience (1245 orthopaedic procedures during the last 25...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-007-0069-3

    authors: Hernigou P,Zilber S,Filippini P,Mathieu G,Poignard A,Galacteros F

    更新日期:2008-02-01 00:00:00