The structure of a biomaterial rather than its chemical composition modulates the repair process at the peritoneal level.

Abstract:

BACKGROUND:This study was designed to establish whether the spatial structure of a prosthesis conditions its behavior at the peritoneal level. METHODS:Abdominal defects comprising all the wall (except skin) were created in rabbits and repaired with a laminar (DM) or reticular (CV-4) ePTFE-prosthesis. Fourteen days postimplant, specimens were obtained for scanning electron and light microscopy. Peritoneal adhesions, resistance to traction, and neoperitoneum thickness were quantified. RESULTS:Adhesions to CV-4 were firm and integrated within surrounding tissue; only scarce adhesion formation was observed for DM. Adhesion area was significantly greater (P <0.01) in the CV-4 than in DM (7.00 +/- 2.6; 0.15 +/- 0.08 cm(2)). The neoperitoneum was organized for DM and disorganized for CV-4. This layer was significantly thicker (P <0.05) in DM than CV-4 (455 +/- 3.4; 70 +/- 3.1 microm). The CV-4 showed a greater resistance to traction than the DM (26.75 +/- 3.71; 14.11 +/- 3.71 N; P <0.05). CONCLUSIONS:The structure of a biomaterial, rather than its chemical composition, modulates behavior at the peritoneal interface.

journal_name

Am J Surg

authors

Bellón JM,Jurado F,García-Honduvilla N,López R,Carrera-San Martín A,Buján J

doi

10.1016/s0002-9610(02)00907-8

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

154-9

issue

2

eissn

0002-9610

issn

1879-1883

pii

S0002961002009078

journal_volume

184

pub_type

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