Abstract:
:We compared the genome of the nematode Caenorhabditis elegans to 13% of that of Caenorhabditis briggsae, identifying 252 conserved segments along their chromosomes. We detected 517 chromosomal rearrangements, with the ratio of translocations to inversions to transpositions being approximately 1:1:2. We estimate that the species diverged 50-120 million years ago, and that since then there have been 4030 rearrangements between their whole genomes. Our estimate of the rearrangement rate, 0.4-1.0 chromosomal breakages/Mb per Myr, is at least four times that of Drosophila, which was previously reported to be the fastest rate among eukaryotes. The breakpoints of translocations are strongly associated with dispersed repeats and gene family members in the C. elegans genome.
journal_name
Genome Resjournal_title
Genome researchauthors
Coghlan A,Wolfe KHdoi
10.1101/gr.172702subject
Has Abstractpub_date
2002-06-01 00:00:00pages
857-67issue
6eissn
1088-9051issn
1549-5469journal_volume
12pub_type
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