Tamoxifen-induced increases in cytoplasmic free Ca2+ levels in human breast cancer cells.

abstract：:In this paper, we report findings from a family-based association study examining the association between polymorphisms in two key estrogen-metabolism genes CYP1B1 (codon 432 G --> C and codon 453 A --> G variants) and COMT (codon 158 G --> A variant) and female breast cancer. We conducted the study among 280 nuclear ...

journal_title：Breast cancer research and treatment

authors： Ahsan H,Chen Y,Whittemore AS,Kibriya MG,Gurvich I,Senie RT,Santella RM

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Women affected with breast cancer who carry a BRCA1 or BRCA2 (BRCA1/2) mutation are at risk of developing contralateral breast cancer. To reduce the risk of contralateral breast cancer, some patients opt for prophylactic surgery of the unaffected breast (contralateral prophylactic mastectomy, CPM) in additio...

journal_title：Breast cancer research and treatment

authors： Graves KD,Peshkin BN,Halbert CH,DeMarco TA,Isaacs C,Schwartz MD

更新日期：2007-09-01 00:00:00

abstract：:The transition from screen-film to digital mammography may have altered diagnostic evaluation of women following a positive screening examination. This study compared the use and timeliness of diagnostic imaging and biopsy for women screened with screen-film or digital mammography. Data were obtained from 35,321 posit...

journal_title：Breast cancer research and treatment

authors： Hubbard RA,Zhu W,Horblyuk R,Karliner L,Sprague BL,Henderson L,Lee D,Onega T,Buist DS,Sweet A

更新日期：2013-04-01 00:00:00

abstract：:PIN1, an isomerase that causes conformational changes in proteins, plays an important role in mammary epithelial cell growth both physiologically and pathologically. Thus, genetic variants in the PIN1 gene may alter protein function and cancer risk. We have previously demonstrated an association between a PIN1 promote...

journal_title：Breast cancer research and treatment

authors： Han CH,Lu J,Wei Q,Bondy ML,Brewster AM,Yu TK,Buchholz TA,Arun BK,Wang LE

更新日期：2010-07-01 00:00:00

abstract：:Over the last several years, evidence has accumulated to support the idea that rare Ha-ras polymorphisms are associated with inherited susceptibility to certain human cancers. A recent epidemiologic study conducted at our institution found a significant association specifically with breast cancer, although the mechani...

journal_title：Breast cancer research and treatment

authors： Conway K,Edmiston S,Fried DB,Hulka BS,Garrett PA,Liu ET

更新日期：1995-07-01 00:00:00

abstract：:Our previous studies have shown that social housing conditions can significantly alter the growth rate of the Shionogi mouse mammary carcinoma (SC115). The present study extended our investigations to the molecular level by examining stressor effects on the expression of a group of stress-responsive proteins, the heat...

journal_title：Breast cancer research and treatment

authors： Andrews HN,Kerr LR,Strange KS,Emerman JT,Weinberg J

更新日期：2000-02-01 00:00:00

abstract：:Wide fluctuations in results obtained by different laboratories for the content of estrogen receptors from a single source of tissue powder were reported by several investigators at the 1979 NCI Consensus Committee Meeting for Steroid Receptors in Breast Cancer and were further supported by data collected by our labor...

journal_title：Breast cancer research and treatment

authors： Raam S,Gelman R,Faulkner J,White GM,Cohen JL

更新日期：1982-01-01 00:00:00

abstract：:The purpose of this meta-analysis was to analyze the available evidence concerning the effects of depression on non-adherence to adjuvant endocrine therapy (AET) in women with breast cancer. MEDLINE and PsycInfo databases from inception through May 1, 2015 were searched using terms related to AET adherence. Articles w...

journal_title：Breast cancer research and treatment

authors： Mausbach BT,Schwab RB,Irwin SA

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC). The IBC phenotype is characterized by an infiltrative growth pattern, increased (lymph)angiogenesis and the propensity to invade dermal lymphatics. In pancreatic cancer, interactions between caveolin-1 and Rho...

journal_title：Breast cancer research and treatment

authors： Van den Eynden GG,Van Laere SJ,Van der Auwera I,Merajver SD,Van Marck EA,van Dam P,Vermeulen PB,Dirix LY,van Golen KL

更新日期：2006-02-01 00:00:00

abstract：:To further clarify risk factors for breast cancer in Japanese women, a self-administered questionnaire was completed by 157 cases with histologically confirmed breast cancer from 1989 to 1993 and by 369 age and residential area matched controls in Gifu, Japan. Conditional logistic regression model was used to assess t...

journal_title：Breast cancer research and treatment

authors： Hu YH,Nagata C,Shimizu H,Kaneda N,Kashiki Y

更新日期：1997-03-01 00:00:00

abstract：:Macroautophagy (autophagy), a process for lysosomal degradation of organelles and long-lived proteins, has been linked to various pathologies including cancer and to the cellular response to anticancer therapies. In the human estrogen receptor positive MCF7 breast adenocarcinoma cell line, treatment with the endocrine...

journal_title：Breast cancer research and treatment

authors： Qadir MA,Kwok B,Dragowska WH,To KH,Le D,Bally MB,Gorski SM

更新日期：2008-12-01 00:00:00

abstract：:The sensitivity of breast neoplasms to hormonal control provides the basis of novel investigational treatments with steroidal alkylators. An androsterone D-lactam steroidal ester, the 3beta-hydroxy-13alpha-amino-13,17-seco- 5alpha-androstan-17-oic-13,17-lactam, p-bis(2-chloroethyl)amino phenyl acetate (lactandrate) wa...

journal_title：Breast cancer research and treatment

authors： Trafalis DT,Geromichalos GD,Koukoulitsa C,Papageorgiou A,Karamanakos P,Camoutsis C

更新日期：2006-05-01 00:00:00

abstract：:It has long been hypothesized that personality is associated with breast cancer risk and survival. The present population-based prospective cohort study in Japan tested this hypothesis. To investigate the association of personality with breast cancer risk, a total of 15,107 women aged 40-64 years who completed the Eys...

journal_title：Breast cancer research and treatment

authors： Minami Y,Hosokawa T,Nakaya N,Sugawara Y,Nishino Y,Kakugawa Y,Fukao A,Tsuji I

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Epithelial-to-mesenchymal transition (EMT) has been implicated as an important step in the development of distant metastases. We therefore wished to study EMT status of primary breast carcinomas from patients who during follow-up developed distant metastases. METHODS:mRNA expression profiles of primary brea...

journal_title：Breast cancer research and treatment

authors： Savci-Heijink CD,Halfwerk H,Hooijer GKJ,Koster J,Horlings HM,Meijer SL,van de Vijver MJ

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:In 2003, for the first time, US breast cancer incidence rates have fallen. Experts argue whether this is due to the reduced uptake of screening mammography or to lower use of Hormone Replacement Therapy (HRT). This study aims to disentangle the respective impact of screening and HRT on age-incidence rates an...

journal_title：Breast cancer research and treatment

authors： Verkooijen HM,Koot VC,Fioretta G,van der Heiden M,Schipper ME,Rapiti E,Peeters PH,Peterse JL,Bouchardy C

更新日期：2008-02-01 00:00:00

abstract：:The diagnosis and treatment of patients with breast cancer is beginning to be influenced by new ideas and discoveries emerging from the field of angiogenesis research. This field, pursued in the laboratory for more than 20 years, has in the past 5 years generated clinical applications. Some of these applications have ...

journal_title：Breast cancer research and treatment

authors： Folkman J

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Among patients diagnosed with breast cancer (BC), women also living with HIV (WLWH) have worse survival than women without HIV. Chronic HIV infection may interfere with the effectiveness of BC treatment, contributing to this disparity. We attempted to determine the impact of HIV infection on response to neoadju...

journal_title：Breast cancer research and treatment

authors： Nietz S,O'Neil DS,Ayeni O,Chen WC,Joffe M,Jacobson JS,Neugut AI,Ruff P,Mapanga W,Buccimazza I,Singh U,Čačala S,Stopforth L,Phakathi B,Chirwa T,Cubasch H

更新日期：2020-12-01 00:00:00

abstract：:Estrogen receptor (ER)-positive/progesterone receptor (PR)-positive invasive ductal carcinoma accounts for ~45 % of invasive breast cancer (BC) diagnoses in the U.S. Despite reductions in BC mortality attributable to mammography screening and adjuvant hormonal therapy, an important challenge remains the development of...

journal_title：Breast cancer research and treatment

authors： Buas MF,Rho JH,Chai X,Zhang Y,Lampe PD,Li CI

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Results from four major hypofractionated whole-breast radiotherapy (HF-WBRT) trials have demonstrated equivalence in select patients with early-stage breast cancer when compared with conventionally fractionated WBRT (CF-WBRT). Because relatively little data were available on patients receiving neoadjuvant or ad...

journal_title：Breast cancer research and treatment

authors： Diwanji TP,Molitoris JK,Chhabra AM,Snider JW,Bentzen SM,Tkaczuk KH,Rosenblatt PY,Kesmodel SB,Bellavance EC,Cohen RJ,Cheston SB,Nichols EM,Feigenberg SJ

更新日期：2017-09-01 00:00:00

abstract：:Feasibility of utilizing the 6-day subrenal capsule (SRC) assay to screen drugs against fresh surgical explants of human tumors was confirmed by testing six clinically active chemotherapeutic agents against 141 human breast cancers. Response rates of the six drugs obtained in the assay compared favorably with clinical...

journal_title：Breast cancer research and treatment

authors： Bogden AE,Costanza ME,Reich SD,Griffin TW,Cobb WR

更新日期：1983-01-01 00:00:00

abstract：:Platinum agents such as cisplatin and carboplatin are DNA-damaging agents with activity in breast cancer (BC), particularly in the triple negative (TN) subgroup. The utility of platinum agents, in addition to standard neoadjuvant chemotherapy (NAC), is controversial. To assess the activity of platinum agents in patien...

journal_title：Breast cancer research and treatment

authors： Petrelli F,Coinu A,Borgonovo K,Cabiddu M,Ghilardi M,Lonati V,Barni S

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:Evidence suggests that premenopausal obesity decreases and postmenopausal obesity increases breast cancer risk. Because it is not well known whether this is subtype dependent, we studied the association between body mass index (BMI) and age at breast cancer diagnosis, or the probability of being diagnosed with ...

journal_title：Breast cancer research and treatment

authors： Brouckaert O,Van Asten K,Laenen A,Soubry A,Smeets A,Nevelstreen I,Vergote I,Wildiers H,Paridaens R,Van Limbergen E,Weltens C,Moerman P,Floris G,Neven P,Multidisciplinary breast centre Leuven.

更新日期：2018-02-01 00:00:00

abstract：:We have measured the levels of tamoxifen and three of its metabolites in the blood of patients receiving tamoxifen alone or combination therapy with tamoxifen and medroxyprogesterone acetate. Our results indicate that addition of the progestogen significantly alters the metabolism of tamoxifen over a six-month period....

journal_title：Breast cancer research and treatment

authors： Reid AD,Horobin JM,Newman EL,Preece PE

更新日期：1992-01-01 00:00:00

abstract：:Alcohol consumption is a risk factor for breast cancer in humans. Experimental studies indicate that alcohol exposure promotes malignant progression of mammary tumors. However, the underlying cellular and molecular mechanisms remain unclear. Alcohol induces a pro-inflammatory response by modulating the expression of c...

journal_title：Breast cancer research and treatment

authors： Wang S,Xu M,Li F,Wang X,Bower KA,Frank JA,Lu Y,Chen G,Zhang Z,Ke Z,Shi X,Luo J

更新日期：2012-06-01 00:00:00

abstract：:M1775R and A1789T are two missense variants located within the BRCT domains of BRCA1 gene. The M1775R is a known deleterious variant, while the A1789T is an unclassified variant that has been analyzed and classified as probably deleterious for the first time by our group. In a previous study, we described the expressi...

journal_title：Breast cancer research and treatment

authors： Guglielmi C,Cerri I,Evangelista M,Collavoli A,Tancredi M,Aretini P,Caligo MA

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:A positive margin after breast conserving surgery has consistently been shown to be a significant predictor for ipsilateral breast tumor recurrence. Currently, there is no standard for intraoperative margin assessment during lumpectomy, and up to 20% of cases result in positive margins. MarginProbe is a device ...

journal_title：Breast cancer research and treatment

authors： LeeVan E,Ho BT,Seto S,Shen J

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Women with benign breast disease (BBD) have an increased risk of subsequent breast cancer. However, whether conventional breast cancer risk factors influence risk of breast cancer among women with BBD is unclear. In this study, we investigated the associations of lifestyle, menstrual/reproductive, and histologi...

journal_title：Breast cancer research and treatment

authors： Arthur R,Wang Y,Ye K,Glass AG,Ginsberg M,Loudig O,Rohan T

更新日期：2017-10-01 00:00:00

abstract：:Forty-one women with non-metastatic but locally advanced breast cancer were treated by modified radical or radical mastectomy, and were then randomized to receive one of two adjuvant chemotherapy regimens. Regimen A consisted of 6 months of cyclophosphamide, adriamycin, and fluorouracil (CAF) followed by 6 months of c...

journal_title：Breast cancer research and treatment

authors： Casper ES,Guidera CA,Bosl GJ,Hakes TB,Kaufman RJ,Shurgot B,Kinne DW

更新日期：1987-01-01 00:00:00

abstract：:Studies from Western countries have found evidence of a recent decline in breast cancer incidence rates in postmenopausal women, findings which have been hypothesized to reflect a reduced use of hormonal replacement therapy (HRT). We examined breast cancer incidence trends in Sweden between 1997 and 2007, a period cha...

journal_title：Breast cancer research and treatment

authors： Lambe M,Wigertz A,Holmqvist M,Adolfsson J,Bardage C,Fornander T,Karlsson P,Odlind V,Persson I,Ahlgren J,Bergkvist L

更新日期：2010-06-01 00:00:00

abstract：:We aimed to analyse the impact of breast cancer (BC) subtypes on the clinical course of disease with special emphasis on the occurrence of brain metastases (BM) and outcome in an elderly BC population. A total number of 706 patients ≥65 years receiving treatment for BC from 2007 to 2011 were identified from a BC datab...

journal_title：Breast cancer research and treatment

authors： Bergen ES,Tichy C,Berghoff AS,Rudas M,Dubsky P,Bago-Horvath Z,Mader RM,Exner R,Gnant M,Zielinski CC,Steger GG,Preusser M,Bartsch R

更新日期：2016-05-01 00:00:00