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Inhibition of the pulmonary inactivation of prostaglandins in vivo by di-4-phloretin phosphate.

Abstract：

:1 Inactivation of prostaglandin E2 in the pulmonary circulation of rabbits in vivo was measured by comparing the hypotensive effects of doses given intravenously and intra-arterially. 2 Di-4-phloretin phosphate (DPP) 25-100 mug kg-1 min-1 inhibited the inactivation of prostaglandin E2 in the pulmonary circulation. 3 These doses of DPP caused a marked shift to the left of the dose-response curve to prostaglandin E2 given intravenously but did not affect the dose-response curve to prostaglandin E2 given intra-arterially. 4 Inhibition of pulmonary inactivation of prostaglandins E2 and F2alpha caused marked potentiation of their gastrointestinal effects. 5 At these doses antagonism of the hypotensive action of prostaglandin E2 by DPP was seldom seen but the gastrointestinal effect of prostaglandin F2alpha was sometimes antagonized. 6 After treatment with DPP 100 mug kg-1 min-1, high doses of prostaglandin were sometimes lethal.

journal_name

Br J Pharmacol

journal_title

British journal of pharmacology

authors

Crutchley DJ,Piper PJ

doi

10.1111/j.1476-5381.1975.tb07569.x

subject

Has Abstract

pub_date

1975-07-01 00:00:00

pages

301-7

issue

3

eissn

0007-1188

issn

1476-5381

journal_volume

54

pub_type

杂志文章

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