Abstract：
OBJECTIVE:The aim of this study was to investigate the effects of topotecan (Hycamtin), a topoisomerase I inhibiting anticancer agent, on Transient Evoked Otoacoustic Emissions (TEOAEs) of the rabbits. We planned to investigate whether this test might provide a method for monitoring early ototoxic influence of drug administration to the cochlea. METHODS:The study was conveyed in two groups each consisting of five rabbits with a total of ten ears. Rabbits in group I received i.v. topotecan (0.5 mg/kg once daily) for 3 days. Rabbits in group II received i.v. topotecan (0.25 mg/kg once daily) for 3 days. Cochlear function was serially monitored using transient evoked otoacoustic emissions before administration (BA) and on the 4th and 15th days after administration of topotecan. TEOAEs were analysed in terms of mean stimulus, stability and emission amplitude at 1.0-4.0 kHz. RESULTS:For group I and II, intergroup and intragroup differences were not statistically significant in the mean stimulus, stability and emission amplitudes at 1.0-4.0 kHz. CONCLUSIONS:We evaluated the potential role of TEOAEs in early identification of cochlear dysfunction induced by topotecan. It was concluded that topotecan did not have ototoxic effects on the cochlea in the early period of administration. TEOAEs may be useful to monitor the cochlear function and to detect the late stage of ototoxicity especially in the presence of potentially toxic factors for the prevention of permanent damage.
journal_name
Int J Pediatr Otorhinolaryngoljournal_title
International journal of pediatric otorhinolaryngologyauthors
Bayar N,Böke B,Apan A,Koç MCdoi
10.1016/s0165-5876(01)00578-xsubject
Has Abstractpub_date
2001-11-01 00:00:00pages
135-42issue
2eissn
0165-5876issn
1872-8464pii
S016558760100578Xjournal_volume
61pub_type
杂志文章abstract：INTRODUCTION:Tele-diagnostic audiological testing in a hearing screening program for infants and young children is a novel practice, and this study is the first to explore its application in a rural community. It is important to understand parental perceptions and confidence when introducing a new process such as tele-...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2016.07.028
更新日期：2016-10-01 00:00:00
abstract：:This prevalence study of secretory otitis media (SOM) comprised 210 children who were not attending or had not attended kindergarten. Children in home care/private day care with up to two children were analyzed separately. In this group the prevalence peak was at one year, being at that age about 40%. The prevalence d...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s0165-5876(86)80013-1
更新日期：1986-04-01 00:00:00
abstract：BACKGROUND:Group A Streptococcus (GAS) is the most important bacterial cause of acute tonsillitis in children. Some children are chronic GAS carriers, and this carriage is poorly understood. We determined the frequency of GAS detection using a rapid antigen detection test in pediatric patients with indications for tons...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2016.03.044
更新日期：2016-07-01 00:00:00
abstract：:Invasive aspergillosis (IA) is a major cause of morbidity and mortality in immunosuppressed patients. Primary oral invasive aspergillosis is a rare condition. We present an acute lymphoblastic leukemia (ALL) patient with hard palate perforation due to invasive aspergillosis. Two months after the appearance of the fung...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2005.03.035
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess the long term results of treatment and rehabilitation of childhood dysphonia. METHODS:This study included a group of adolescents (n=29) aged from 15 to 20 who were treated due to pediatric hyperfunctional dysphonia and soft vocal fold nodules during their pre-mutational pe...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2014.02.002
更新日期：2014-05-01 00:00:00
abstract：:We report a case of bilateral duplication of the internal auditory canal (IAC). An 11-month-old girl with congenital profound hearing loss was referred to our hospital. Imaging evaluations revealed bilateral IAC duplication, which contained the facial and cochleovestibular nerves in one canal, but no nerves in the oth...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2015.07.004
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVES:The aim of this longitudinal follow-up study was to explore the trajectories of early auditory and language development in Mandarin speaking children younger than 3 years of age following switch-on of their cochlear implants (CIs). METHODS:Early auditory and language development was measured longitudinally ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2019.109720
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:Acute infection of the sphenoid sinus usually affects both pre-adolescent and adolescent subjects and is associated with infections of the other paranasal sinuses. Acute isolated sphenoiditis, though uncommon, is frequently misdiagnosed as symptoms are vague and there are few clinical findings. Indeed, it is ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.ijporl.2006.07.011
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVE:Mutations in GJB2 and GJB6 genes are a frequent cause of congenital non-syndromic hearing loss (NSHL). Mutational screening has usually focused on coding region of GJB2 gene. A few studies have been conducted on the non-coding region and exon 1. c.IVS1+1G>A (a splice site mutation in GJB2 gene have been detec...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2016.11.015
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:To determine the nasopharyngeal aerobic bacterial flora and Staphylococcus aureus nasal carriage in deaf children and the role of flora in deafness. STUDY DESIGN:A prospective, controlled study. METHODS:Nasopharyngeal and nasal swabs were collected from 87 deaf children with acquired etiology at Zonguldak p...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2004.08.005
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:Comprehensive quantitative evaluation of the intercarotid artery distance (ICD) in the pediatric population has not been sufficiently explored. This study aims to measure the minimal ICDs at multiple levels of the skull base to assess changes in the ICD during development. METHODS:Measurement of the ICDs bet...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2020.110520
更新日期：2021-01-01 00:00:00
abstract：UNLABELLED:The cause of upper respiratory tract infections (URTI) are multifactorial (enlarged adenoid, environmental conditions, staying at the care centers, smoking parents, allergy). Directly, viral infection causes damage to the ciliary cells and mucociliary clearance in the nasopharynx and Eustachian tube, promote...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s0165-5876(99)00178-0
更新日期：1999-10-05 00:00:00
abstract：:The effect of a beclomethasone dipropionate nasal spray on middle ear effusion was tested in a double-blind study of drug vs placebo (vehicle). Seventy children, aged 4-14 years, sprayed each nostril twice daily for one month. Among them 35 received a daily dose of 400 micrograms of the beclomethasone. The results of ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 临床试验,杂志文章
doi：10.1016/0165-5876(82)90088-x
更新日期：1982-06-01 00:00:00
abstract：OBJECTIVE:CHARGE syndrome is a heterogeneous genetic disorder comprising multiple congenital anomalies. Major clinical diagnostic criteria include ocular coloboma, choanal atresia/stenosis, characteristic ear abnormalities, and cranial nerve abnormalities. CHARGE syndrome is caused by a mutation in the gene CHD7 locate...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2008.10.005
更新日期：2009-02-01 00:00:00
abstract：:Granular cell tumor, a relative rare neoplasm, is of particular interest of the otolaryngologist as some 50% of cases appear in the head and neck region. The youngest reported case of a laryngeal granular cell tumor is presented. Involvement of the larynx is uncommon, but when it occurs it may create diagnostic and th...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/0165-5876(88)90081-x
更新日期：1988-09-01 00:00:00
abstract：:Haemangiomas are the most common soft tissue tumor of infancy. Despite the benign and trivial nature of most cutaneous haemangiomas, airway haemangiomas are rare but potentially life threatening. We report the case of a 9-week-old infant with a left main stem bronchial haemangioma. This was successfully treated with t...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s0165-5876(02)00403-2
更新日期：2003-04-01 00:00:00
abstract：INTRODUCTION:Hearing loss in children is a common entity worldwide. We examined the prevalence and etiology of hearing loss among primary school children in Mbarara, Uganda. METHODS:Cross-sectional study in primary school children aged 5-14 was performed to determine the prevalence of hearing loss. Ugandan primary sch...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2015.10.044
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:While tracheal resection for management of tracheal stenosis is an effective technique that has been well described in adults, the results in children have been less encouraging, as children tolerate anastomotic tension less well than adults. We describe our current technique for the management of severe trac...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2003.08.054
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the growth during the first two years of life in infants after unilateral cleft lip and palate neonatal repair. METHOD:All mature infants with nonsyndromic unilateral cleft lip and palate (NSUCLP) born between 2004 and 2007 were included. Information concerning growth was collected. Weight and le...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2010.01.020
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVES:Where various surgical options exist for solving the same problem, and the results are similar, Occam's razor may be a suitable way of deciding which technique to use. The postaural [retroauricular] approach in myringoplasty is favoured generally, for its reported better overview of the middle ear. However, ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2009.08.010
更新日期：2009-11-01 00:00:00
abstract：:Otofaciocervical syndrome (OFCS) is a rare disorder characterized by facial, ear, branchial, and musculoskeletal anomalies, along with hearing loss and mild intellectual disability. Clinically, its distinction from branchiootorenal syndrome can be difficult. To date, the coexistence of OFCS and metachondromatosis has ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2016.03.021
更新日期：2016-06-01 00:00:00
abstract：INTRODUCTION:Children with tracheostomies are medically complex and may be discharged with limited and variably trained home nursing support. When faced with emergencies at home, caregivers must often take the lead role in management, and many lack experience with troubleshooting these emergencies prior to initial disc...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2019.01.020
更新日期：2019-05-01 00:00:00
abstract：:Paranasal sinus mucoceles are rare in children. The traditional treatment is to perform surgical drainage via an external incision. In adults endonasal surgical techniques are increasingly being used to treat mucoceles. A series of seven children is reported. All cases were successfully treated with endoscopic intrana...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s0165-5876(99)00220-7
更新日期：1999-10-25 00:00:00
abstract：OBJECTIVE:Voice disorders in children are common but ways of their analysis are limited. We conducted a prospective feasibility study of rigid stroboscopy in children. METHODS:All children referred for voice analysis during the years 2002-2003 were evaluated including subjective perception of voice, voice recording, f...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2005.03.004
更新日期：2005-08-01 00:00:00
abstract：:During 1991-1999, in the Children's ENT Department of Warsaw Medical University, 39 polypectomies were performed. We analysed the histological structure of all polyps. The most common type of nasal polyp tissue in children was the inflammatory polyp (95% of cases). ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s0165-5876(01)00508-0
更新日期：2001-08-20 00:00:00
abstract：OBJECTIVES:Sensorineural hearing impairment (HI) is one of the most frequent congenital defects, with a prevalence of 1 in 500 among neonates. Although there are over 400 syndromes involving HI, most cases of HI are nonsyndromic (70%), 20% of which follow autosomal dominant mode of inheritance. Waardenburg syndrome (WS...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2015.07.039
更新日期：2015-10-01 00:00:00
abstract：INTRODUCTION:Primary ciliary dyskinesia (PCD) is an autosomal recessive genetic disease, which primarily manifests with oto-sino-pulmonary symptoms. Otitis media with effusion (OME) is common from early childhood. The existing literature on OME management in PCD is conflicting. The goals of the present study were first...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2016.08.011
更新日期：2016-10-01 00:00:00
abstract：:We present two siblings with severe laryngomalacia requiring surgical intervention during the newborn period, microcephaly, developmental delay, cleft palate, preaxial polydactyly, dysplastic nails and conductive hearing loss (persistent after tympanostomy tube placement). In addition the girl has microopthalmia and t...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.ijporl.2006.04.010
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:Nontypeable Haemophilus influenzae (NTHi) is one of the leading causative pathogens for otitis media. The outer membrane protein P6 of NTHi is highly conserved among the strains and is an attractive candidate for a preventive vaccine. However, for the production of a relatively small amount P6 containing lipo...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s0165-5876(02)00076-9
更新日期：2002-09-02 00:00:00
abstract：:Seventy health children underwent an OKN trial. The authors have chosen to perform only four tests (slow and fast clockwise and counterclockwise OKN) taking into account (in agreement with several international studies) four parameters: sTAP, fTAP, sTSAP, fTSAP (where s and f indicate the velocity of the shifting targ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 临床试验,杂志文章
doi：10.1016/s0165-5876(97)00029-3
更新日期：1997-06-20 00:00:00
