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Valproate induces in vitro accumulation of long-chain fatty acylcarnitines.

Abstract：

:To elucidate the interference mechanisms of valproate (VPA) with mitochondrial fatty acid beta-oxidation (FAO), the profile of acylcarnitine formation was studied in vitro. Human fibroblasts were incubated with 0.2 mmol/L [U-(13)C]palmitate, 0.4 mmol/L l-carnitine, +/- VPA (2 mmol/L) (96 h at 37 degrees C). Acylcarnitines (AC) were analyzed by GC-CI-MS. VPA induced an impaired production of acetylcarnitine (C2) and an increase on long-chain AC (C10 to C16) both in control and in FAO-deficient cell lines (VLCAD, LCHAD, MTP).

journal_name

Mol Genet Metab

journal_title

Molecular genetics and metabolism

authors

Silva MF,Jakobs C,Duran M,de Almeida IT,Wanders RJ

doi

10.1006/mgme.2001.3200

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

358-61

issue

4

eissn

1096-7192

issn

1096-7206

pii

S1096-7192(01)93200-7

journal_volume

73

pub_type

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