Critical appraisal of the significance of intrathoracic anastomotic leakage after esophagectomy for cancer.

Abstract:

BACKGROUND:Leakage from esophageal anastomoses is higher than that for other gastrointestinal anastomoses. An intrathoracic anastomotic leak is a potentially catastrophic event. METHODS:Patients with and without thoracic anastomotic leakage were compared for predisposing factors. Leak-related mortality was analyzed. RESULTS:Of 475 patients, there were 17 leaks (3.5%). Predisposing technical factors occurred significantly more frequently in patients who leaked. Sixteen such events were identified as contributory in 11 patients. The hospital mortality for patients who leaked was significantly higher (35% versus 9%, P = 0.005). Inadequate drainage and persistent sepsis accounted for 4 of the 6 deaths. The need for inotropic support postoperatively correlated with leak-related mortality (66% versus 0%, P = 0.006), while leak size, time to diagnosis, or method of drainage did not. CONCLUSIONS:Thoracic anastomotic leaks are largely preventable. Leak-related mortality for the series was 1% and was most commonly related to inadequate drainage.

journal_name

Am J Surg

authors

Whooley BP,Law S,Alexandrou A,Murthy SC,Wong J

doi

10.1016/s0002-9610(01)00559-1

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

198-203

issue

3

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(01)00559-1

journal_volume

181

pub_type

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