Factors directly affecting impulse transmission in inflammatory demyelinating disease: recent advances in our understanding.

abstract：:Slowly, advances are being made in the understanding and treatment of primary childhood brain tumors. The addition of chemotherapy has resulted in better survival for children with medulloblastoma. For other tumor types, therapeutic advances have been slower. High-dose chemotherapy is increasingly being employed to tr...

journal_title：Current opinion in neurology

authors： Packer RJ

更新日期：1997-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Here we discuss recent advances regarding the molecular genetic basis of dominantly inherited ataxias. RECENT FINDINGS:Important recent observations include insights into the mechanisms by which expanded polyglutamine causes cerebellar degeneration; new findings regarding how noncoding expansions may...

journal_title：Current opinion in neurology

authors： Soong BW,Paulson HL

更新日期：2007-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To gain a complete understanding of how the brain functions, both in illness and good health, data from multiple levels of analysis must be integrated. Technical advances have made direct recordings of neuronal activity deep inside the human brain tractable, providing a rare glimpse into cellular proc...

journal_title：Current opinion in neurology

authors： Viskontas IV

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Cognitive impairments are common in children with epilepsy. They may already be present before the onset of epilepsy or occur - and even progress - during its course. Many variables contribute to cognitive dysfunction. Those that can be targeted to prevent (further) cognitive impairment will be highli...

journal_title：Current opinion in neurology

authors： Braun KP

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the currently known side effects of the approved therapies of multiple sclerosis and to suggest monitoring procedures. RECENT FINDINGS:The progress in the treatment of multiple sclerosis with new very effective therapies is accompanied by a number of side effects. Some of these have alre...

journal_title：Current opinion in neurology

authors： Moiola L,Rommer PS,Zettl UK

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Gadolinium-enhancement depicts blood-brain barrier disruption associated with new inflammatory MRI lesions in multiple sclerosis (MS) and is widely used for diagnosis and therapeutic monitoring. However, earlier and more specific markers of inflammation are urgently needed. RECENT FINDINGS:Susceptibi...

journal_title：Current opinion in neurology

authors： Hagens M,van Berckel B,Barkhof F

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Drug resistance is an important clinical problem: it is associated with higher rates of somatic and psychiatric comorbidities and cognitive/memory decline, with seizures being just the 'tip of the iceberg'. This review summarizes recent developments in imaging research, focusing specifically on the fu...

journal_title：Current opinion in neurology

authors： Koepp MJ

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The 2016 WHO classification of tumors of the central nervous system (2016 CNS WHO) features many changes that are relevant to neurologists treating patients with brain tumors as well as neurologists involved in basic, clinical, and epidemiological research. This review summarizes what neurologists nee...

journal_title：Current opinion in neurology

authors： DeWitt JC,Mock A,Louis DN

更新日期：2017-12-01 00:00:00

abstract：:Three genetic loci for Alzheimer's disease have been identified. These are the amyloid precursor gene on chromosome 21, a gene for early-onset autosomal dominant Alzheimer's disease on chromosome 14, and the risk-modifying gene APOE on chromosome 19. Additional Alzheimer's disease genes remain to be found. The genes i...

journal_title：Current opinion in neurology

authors： Schellenberg GD

更新日期：1995-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines the applicability of a framework of frontal lobe functioning to understand the sequelae of traumatic brain injury (TBI). RECENT FINDINGS:TBI research illustrates the need for improved phenotyping of TBI outcome. The functions of the frontal lobes are divisible into four distinct ...

journal_title：Current opinion in neurology

authors： Stuss DT

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent advances in the diagnostic approaches and the underlying pathophysiological mechanisms of Charcot-Marie-Tooth (CMT) disease. We also discuss the emerging therapies for this hereditary neuropathy. RECENT FINDINGS:To date, numerous genes are implicated in CMT, and new gene...

journal_title：Current opinion in neurology

authors： Vallat JM,Mathis S,Funalot B

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammation is implicated in ischaemic stroke as a general cardiovascular risk factor, a possible immediate trigger, a component (and possible exacerbating factor) of the response to tissue injury, a marker of future risk, and as a therapeutic target. Each aspect is reviewed. RECENT FINDINGS:Evidenc...

journal_title：Current opinion in neurology

authors： Muir KW,Tyrrell P,Sattar N,Warburton E

更新日期：2007-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes currently available treatment options and treatment strategies, investigational treatments, and the importance of exercise for early Parkinson's disease. RECENT FINDINGS:The available treatment options for early Parkinson's disease have changed little in the past decade and inc...

journal_title：Current opinion in neurology

authors： Pahwa R,Lyons KE

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review presents the new terms and concepts proposed by the International League Against Epilepsy (ILAE) Classification Commission in 2010 to describe seizures and epilepsies. This is the first major revision in 21 years and reflects the rapid evolution in our understanding of the epilepsies. REC...

journal_title：Current opinion in neurology

authors： Korff CM,Scheffer IE

更新日期：2013-04-01 00:00:00

abstract：:Recent positron emission tomography investigations found spreading oligemia in the early phases of a human migraine attack. During the headache phase, increased cerebral blood flow was found in cortical sensory association areas and unilaterally in the brainstem. The brainstem activation persisted after complete relie...

journal_title：Current opinion in neurology

authors： Diener HC,May A

更新日期：1996-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize why there are polarized opinions regarding the management of patients with asymptomatic carotid disease and whether it is possible to identify patients who might benefit from carotid interventions. RECENT FINDINGS:Carotid Revascularization Endarterectomy Versus Stenting Trial and Asympto...

journal_title：Current opinion in neurology

authors： Naylor AR

更新日期：2017-02-01 00:00:00

abstract：:Recent discoveries emanating from basic electrophysiological, anatomical, and pharmacological studies have implications for the diagnosis and treatment of clinical disorders of eye movements caused by disease affecting the brainstem and cerebellum. Electrophysiological studies have better defined the role of the super...

journal_title：Current opinion in neurology

authors： Averbuch-Heller L,Leigh RJ

更新日期：1996-02-01 00:00:00

abstract：:A relatively small number of studies were published on the intra-arterial therapy of stroke in the past year. Those reports, however, do offer strong evidence for the feasibility and safety of this therapeutic approach. Partly on the basis of these data it has become evident that the intra-arterial thrombolytic therap...

journal_title：Current opinion in neurology

authors： Abou-Chebl A,Furlan AJ

更新日期：2000-02-01 00:00:00

abstract：:New reports of the incidence, prevalence and mortality of Parkinson's disease and parkinsonism are reviewed. Evidence for occupational and lifestyle risk factors and protective factors is updated. Recent genetic epidemiology studies of parkinsonism in twins and families, and studies that investigated imaging and physi...

journal_title：Current opinion in neurology

authors： Tanner CM,Aston DA

更新日期：2000-08-01 00:00:00

abstract：:Positron emission tomography, single photon emission computed tomography and magnetic resonance spectroscopy provide distinct, uncorrelated and sensitive indicators of brain tumors which can be used to improve differential diagnosis, biopsy guidance or therapy monitoring. New findings, including conflicting ethyl-cyst...

journal_title：Current opinion in neurology

authors： Slosman DO,Lazeyras F

更新日期：1996-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Trigeminal autonomic cephalgias (TACs) are characterized by frequent, short-lasting headache attacks with ipsilateral facial autonomic features. They include cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing. The...

journal_title：Current opinion in neurology

authors： Wilbrink LA,Ferrari MD,Kruit MC,Haan J

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Stroke is the third leading cause of death after myocardial infarction and cancer, and is the leading cause of permanent disability and disability-adjusted loss of independent life-years in western countries. Thrombolysis is the treatment of choice for acute stroke within 3 h after the onset of sympto...

journal_title：Current opinion in neurology

authors： Schellinger PD,Kaste M,Hacke W

更新日期：2004-02-01 00:00:00

abstract：:This article reviews the current knowledge with regard to neurotoxicity of conventional radiation, including recent understanding of the pathophysiology, molecular biology, diagnostic evaluation and clinical presentations, as well as proposed treatment modalities and possible protective agents. ...

journal_title：Current opinion in neurology

authors： New P

更新日期：2001-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe new features on the epidemiology of encephalitis world-wide. As this neurological presentation is most frequently related to transmitted viruses, surveillance of encephalitis is of major importance to detect their emergence or re-emergence. RECENT FINDINGS:Rabies causes o...

journal_title：Current opinion in neurology

authors： Stahl JP,Mailles A

更新日期：2014-06-01 00:00:00

abstract：:Disability following head injury varies depending on injury mechanism, neuropathology, and other factors, including medical complications. Mild head injury (Glasgow Coma Scale score 13-15) has been shown to have considerable variability in outcome. Some persons experience rapid symptom resolution whereas others contin...

journal_title：Current opinion in neurology

authors： Macciocchi SN,Reid DB,Barth JT

更新日期：1993-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinical MRI is of paramount importance for multiple sclerosis diagnosis but lacks the specificity to investigate the pathogenic mechanisms underlying disease onset and progression. The application of advanced MR sequences allows the characterization of diverse and complex pathological mechanisms, gra...

journal_title：Current opinion in neurology

authors： Inglese M,Petracca M

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review will outline neuroprotective and neurotoxic effects of central nervous system (CNS) infiltrating T cells during viral infections. Evidence demonstrating differential roles for antiviral effector and resident memory T-cell subsets in virologic control and immunopathology in the CNS w...

journal_title：Current opinion in neurology

authors： Ai S,Klein RS

更新日期：2020-06-01 00:00:00

abstract：:Since the first successful attempts in 1990, human embryonic tissue transplantation has attracted the attention of multiple investigators and clinicians as a serious candidate therapy for Parkinson's disease. Although over two hundred patients have undergone the procedure, multiple issues and questions remain unresolv...

journal_title：Current opinion in neurology

authors： Tabbal S,Fahn S,Frucht S

更新日期：1998-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Malingered anterograde amnesia is a phenomenon that has been exhaustively studied, whereas research on retrograde amnesia has tended to focus upon functional and organic accounts of impairment. The present review explores studies relevant to extending the malingering paradigm to retrograde amnesia. R...

journal_title：Current opinion in neurology

authors： Jenkins KG,Kapur N,Kopelman MD

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The funduscopic examination can be a technically difficult, and often omitted, portion of the neurologic examination, despite its great potential to influence patient care. RECENT FINDINGS:Medical practitioners are often first taught to examine the ocular fundus using a direct ophthalmoscope, however...

journal_title：Current opinion in neurology

authors： Rodenbeck SJ,Mackay DD

更新日期：2019-02-01 00:00:00