Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells.

abstract：:The plasma urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), and urokinase-type plasminogen activator receptor (uPAR) levels were measured in healthy volunteers and breast cancer patients. In pre-menopause healthy females, blood was sampled weekly during one menstruation cycle and ...

journal_title：Breast cancer research and treatment

authors： Chung HC,Rha SY,Park JO,Yoo NC,Kim JH,Roh JK,Min JS,Lee KS,Kim BS,Kim JJ

更新日期：1998-05-01 00:00:00

abstract：:The association between body fat distribution and breast cancer risk was studied in 5923 pre- and 3568 post-menopausal women, participating in a breast cancer screening project (the DOM-project in Utrecht, the Netherlands). Cases were fifty six premenopausal women and thirty eight postmenopausal women with breast canc...

journal_title：Breast cancer research and treatment

authors： den Tonkelaar I,Seidell JC,Collette HJ

更新日期：1995-04-01 00:00:00

abstract：:Breast cancer is the most common malignant tumor-affecting women during the child bearing period. With the rising trend in delaying pregnancy later in life, the issue of subsequent pregnancy and lactation following breast cancer diagnosis has been more frequently encountered. In this context, data is scarce particular...

journal_title：Breast cancer research and treatment

authors： Azim HA Jr,Bellettini G,Gelber S,Peccatori FA

更新日期：2009-03-01 00:00:00

abstract：:Clinical practice guidelines recommend yearly surveillance mammography for breast cancer survivors, yet many women do not receive this service. The objective of this study was to evaluate factors related to long-term surveillance mammography adherence among breast cancer survivors. We conducted a retrospective cohort ...

journal_title：Breast cancer research and treatment

authors： Wirtz HS,Boudreau DM,Gralow JR,Barlow WE,Gray S,Bowles EJ,Buist DS

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:Little is known about racial variations in the financial impact of cancer care. Using data from a national survey of racially diverse patients with metastatic breast cancer, we examined racial/ethnic patterns in employment and cost-management (i.e., financial coping) behaviors. METHODS:We conducted an online s...

journal_title：Breast cancer research and treatment

authors： Samuel CA,Spencer JC,Rosenstein DL,Reeder-Hayes KE,Manning ML,Sellers JB,Wheeler SB

更新日期：2020-01-01 00:00:00

abstract：:Acquired resistance to endocrine therapy in breast cancer is a major clinical problem. Previous reports have demonstrated that cell models of acquired endocrine resistance have altered cell-matrix adhesion and a highly migratory phenotype, features which may impact on tumour spread in vivo. Focal adhesion kinase (FAK)...

journal_title：Breast cancer research and treatment

authors： Hiscox S,Barnfather P,Hayes E,Bramble P,Christensen J,Nicholson RI,Barrett-Lee P

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The phrase "high-risk for breast cancer" is used to identify various groups at elevated cancer risk, and the appropriate surveillance and risk-reducing strategies differ based on the etiology of risk. Here, we review the utility of patient-reported data to capture women with modifiable lifestyle risk factors...

journal_title：Breast cancer research and treatment

authors： Rosenberger LH,Weber R,Sjoberg D,Vickers AJ,Mangino DA,Morrow M,Pilewskie ML

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To evaluate the loco-regional recurrence (LRR) rate after breast-conserving surgery without postoperative radiotherapy (RT) for ductal carcinoma in situ (DCIS) of the breast. METHODS:Between 2000 and 2010, 311 DCIS patients from 9 institutions were analyzed retrospectively. The median age was 47 (range, 20-82)...

journal_title：Breast cancer research and treatment

authors： Kim K,Jung SY,Shin KH,Kim JH,Han W,Lee HB,Huh SJ,Choi DH,Park W,Ahn SD,Kim SS,Kim JH,Suh CO,Kim YB,Kim IA,Kim S,Kim YJ

更新日期：2017-02-01 00:00:00

abstract：:The objective of this study was to determine the conversion rate of human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER) and progesterone receptor (PR) between primary tumors and metastatic lesions in advanced breast cancer. Patients with suspected diagnosis of locally recurrent or metastatic breast...

journal_title：Breast cancer research and treatment

authors： de Dueñas EM,Hernández AL,Zotano AG,Carrión RM,López-Muñiz JI,Novoa SA,Rodríguez AL,Fidalgo JA,Lozano JF,Gasión OB,Carrascal EC,Capilla AH,López-Barajas IB,Mateu MM,de Ceballos Reyna MH,Ferrando AO,Jañez NM,Ballerini VC

更新日期：2014-02-01 00:00:00

abstract：:Adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) have proven highly effective in rapidly proliferating breast cancer (RPBC). It has also been seen that sequential administration of doxorubicin and CMF is superior to their alternation, especially in indolent tumors. In a phase III study, we evaluated w...

journal_title：Breast cancer research and treatment

authors： Amadori D,Silvestrini R,De Lena M,Boccardo F,Rocca A,Scarpi E,Schittulli F,Brandi M,Maltoni R,Serra P,Ponzone R,Biglia N,Gianni L,Tienghi A,Valerio MR,Bonginelli P,Amaducci L,Faedi M,Baldini E,Paradiso A

更新日期：2011-02-01 00:00:00

abstract：:This study analyzes the relationship between coxsackie-adenovirus receptor (CAR) expression (transmembrane and soluble isoforms) and hormone sensitivity in 95 breast cancers. Furthermore, prognostic significance of the expression of the various CAR isoforms was investigated. In addition, inducibility of CAR expression...

journal_title：Breast cancer research and treatment

authors： Auer D,Reimer D,Porto V,Fleischer M,Roessler J,Wiedemair A,Marth C,Müller-Holzner E,Daxenbichler G,Zeimet AG

更新日期：2009-07-01 00:00:00

abstract：:Thirty-eight patients treated for primary breast cancer as part of a prospective randomized clinical trial were questioned retrospectively as to their psychosocial adaptation to treatment. Twenty patients had received mastectomy and eighteen had received excisional biopsy plus radiation of the intact breast. Aside fro...

journal_title：Breast cancer research and treatment

authors： Schain W,Edwards BK,Gorrell CR,de Moss EV,Lippman ME,Gerber LH,Lichter AS

更新日期：1983-01-01 00:00:00

abstract：:Recent studies in patients with breast cancer suggest the immune microenvironment influences response to therapy. We aimed to evaluate the relationship between growth rates of tumors in common spontaneous mammary tumor models and immune biomarkers evaluated in the tumor and blood. TgMMTV-neu and C3(1)-Tag transgenic m...

journal_title：Breast cancer research and treatment

authors： Gad E,Rastetter L,Slota M,Koehnlein M,Treuting PM,Dang Y,Stanton S,Disis ML

更新日期：2014-12-01 00:00:00

abstract：:Magnetic nanoparticles (MNPs) possess unique properties, which make them highly attractive for medical applications. The use of MNPs in surgery has mainly been focused on their role in the identification of metastatic lymph node involvement. There have been developments within this field, including ongoing and newly c...

journal_title：Breast cancer research and treatment

authors： Ahmed M,Douek M

更新日期：2014-01-01 00:00:00

abstract：:Resistance of breast cancers to targeted hormone receptor (HR) or human epidermal growth factor receptor 2 (HER2) inhibitors often occurs through dysregulation of the phosphoinositide 3-kinase, protein kinase B/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway. Presently, no targeted therapies exist for breast...

journal_title：Breast cancer research and treatment

authors： Wilson-Edell KA,Yevtushenko MA,Rothschild DE,Rogers AN,Benz CC

更新日期：2014-04-01 00:00:00

abstract：:We have compared the effects of the progestin R5020 and the antiprogestin RU486 on the growth of the MCF-7 and T47D breast cancer cell lines. Differences between the two compounds were demonstrated in several parameters. 1. Estradiol was required for the efficient inhibition of cell growth of both lines by R5020 but n...

journal_title：Breast cancer research and treatment

authors： Gill PG,Vignon F,Bardon S,Derocq D,Rochefort H

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Breast cancer is characterized by malignant transformation of epithelial cells, but stromal cells also play an important role in tumorigenesis. While tumor-derived fibroblasts display unique phenotypic properties, it is unclear whether they also represent are a specific subpopulation. MATERIALS AND METHODS:...

journal_title：Breast cancer research and treatment

authors： Singer CF,Gschwantler-Kaulich D,Fink-Retter A,Haas C,Hudelist G,Czerwenka K,Kubista E

更新日期：2008-07-01 00:00:00

abstract：:HER2/neu overexpression leads to poorer prognosis and higher risk of disease reoccurrence in breast cancer patients. The causative factors responsible for increasing HER2/neu expression levels on mammary cells are not known. We investigated whether factors associated with inflammation or metastasis could induce HER2/n...

journal_title：Breast cancer research and treatment

authors： Fatunmbi M,Shelton J,Aronica SM

更新日期：2012-09-01 00:00:00

abstract：:Proteins can be efficiently introduced into cells when fused to a protein transduction domain, such as Tat from the human immunodeficiency virus. We recently reported that dendritic cells transduced with a Tat fusion protein containing the extracellular domain of Her2/neu (Tat-Her2/neu) induced CD8 cytotoxic T lymphoc...

journal_title：Breast cancer research and treatment

authors： Viehl CT,Tanaka Y,Chen T,Frey DM,Tran A,Fleming TP,Eberlein TJ,Goedegebuure PS

更新日期：2005-06-01 00:00:00

abstract：:The association of CYP19 gene polymorphisms with breast cancer has been widely reported, but results of previous studies were somewhat contradictory and underpowered. In order to overcome the limitations of individual study and to understand the real situation, we conducted a systematic review and meta-analysis includ...

journal_title：Breast cancer research and treatment

authors： Ma X,Qi X,Chen C,Lin H,Xiong H,Li Y,Jiang J

更新日期：2010-07-01 00:00:00

abstract：:Human mammary epithelial antigens (HME-Ags) are released into the circulation by breast tumors and not by normal breast tissue (Proc. Natl. Acad. Sci. USA 74: 582-586, 1977). This characteristic made them valuable, together with other breast cancer related antigens later identified, to develop immunoassays useful in t...

journal_title：Breast cancer research and treatment

authors： Ceriani RL,Blank EW,Rosenbaum EH,Ben Zeev D,Lowitz RS,Johansen L,Trujillo T

更新日期：1990-05-01 00:00:00

abstract：:The aim of this study is to identify and validate copy number aberrations in early-stage primary breast tumors associated with bone or non-bone metastasis. Whole-genome molecular inversion probe arrays were used to evaluate copy number imbalances (CNIs) in breast tumors from 960 early-stage patients with information a...

journal_title：Breast cancer research and treatment

authors： Liu Y,Zhou R,Baumbusch LO,Tsavachidis S,Brewster AM,Do KA,Sahin A,Hortobagyi GN,Taube JH,Mani SA,Aarøe J,Wärnberg F,Børresen-Dale AL,Mills GB,Thompson PA,Bondy ML

更新日期：2014-01-01 00:00:00

abstract：:In the present report, we retrospectively analyzed the impact of the timing of surgery during menstrual cycle on disease-free and overall survival of 248 premenopausal patients with stage I/II breast cancer who underwent surgery followed by anthracycline-containing adjuvant chemotherapy. With a median follow-up of 5 y...

journal_title：Breast cancer research and treatment

authors： Milella M,Nisticò C,Ferraresi V,Vaccaro A,Fabi A,D'Ottavio AM,Botti C,Giannarelli D,Lopez M,Cortesi E,Foggi CM,Antimi M,Terzoli E,Cognetti F,Papaldo P

更新日期：1999-06-01 00:00:00

abstract：:We attempted to develop a highly sensitive and specific method for the detection of circulating tumor DNA (ctDNA) using a digital PCR (dPCR) assay for PIK3CA mutations (i.e., H1047R, E545K, and E542K) in primary breast cancer patients. The sensitivity of the dPCR assay for the mutant alleles was examined using cell li...

journal_title：Breast cancer research and treatment

authors： Oshiro C,Kagara N,Naoi Y,Shimoda M,Shimomura A,Maruyama N,Shimazu K,Kim SJ,Noguchi S

更新日期：2015-04-01 00:00:00

abstract：:Intraoperative radiotherapy with electrons (ELIOT) after conservative surgery for breast carcinoma was introduced at the IEO in 1999 as a research programme. The results on 1,822 patients treated from January 2000 to December 2008 are reported. Women with unicentric primary breast carcinoma of less than 2.5 cm in the ...

journal_title：Breast cancer research and treatment

authors： Veronesi U,Orecchia R,Luini A,Galimberti V,Zurrida S,Intra M,Veronesi P,Arnone P,Leonardi MC,Ciocca M,Lazzari R,Caldarella P,Rotmensz N,Sangalli C,Sances D,Maisonneuve P

更新日期：2010-11-01 00:00:00

abstract：:Knowledge about long-term consequences of breast cancer treatment on shoulder and arm function and volume in stages I-II breast cancer survivors is limited. The effects of shoulder-arm function shortly after surgery on long-term function are unknown. One hundred and ninety-four women were examined pre-surgery (T0) and...

journal_title：Breast cancer research and treatment

authors： Kootstra JJ,Dijkstra PU,Rietman H,de Vries J,Baas P,Geertzen JH,Hoekstra HJ,Hoekstra-Weebers JE

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:Nearly half of the 3.5 million female breast cancer survivors in the US are aged 65 years or older at diagnosis, yet little is known about associations of obesity and physical activity with breast cancer-specific mortality (BCSM) among older survivors. METHODS:Between 1992 and 2013, 5254 women in the Cancer Pr...

journal_title：Breast cancer research and treatment

authors： Maliniak ML,Patel AV,McCullough ML,Campbell PT,Leach CR,Gapstur SM,Gaudet MM

更新日期：2018-01-01 00:00:00

abstract：:Tamoxifen has been used for the treatment of breast cancer since the 1970s, but is considered a carcinogen because it has been linked to liver cancer in rats and an increased risk of endometrial cancer in patients. In rats, DNA adducts appear to be responsible for carcinogenesis, but their contribution to carcinogenes...

journal_title：Breast cancer research and treatment

authors： Hellmann-Blumberg U,Taras TL,Wurz GT,DeGregorio MW

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:Estimated glomerular filtration rate (eGFR) is commonly used to calculate carboplatin doses and capping the eGFR may be used to reduce the risk of excessive dosing and toxicity. We sought to retrospectively examine the impact of our carboplatin guidelines on pathological complete response rates (pCR) and toxici...

journal_title：Breast cancer research and treatment

authors： Howell SJ,Coe F,Wang X,Horsley L,Ekholm M

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:The ER-/PR-/HER2- or triple-negative (TNBC) subtype is more prevalent among women who are young, black, Hispanic, and of lower SES. The purpose of this study is to determine if young age and low SES are associated with TNBC within four mutually exclusive race/ethnicities. METHODS:The study identified 19,283 ca...

journal_title：Breast cancer research and treatment

authors： Parise CA,Caggiano V

更新日期：2017-05-01 00:00:00