Complement-fixing abilities and IgG subclasses of autoantibodies in epidermolysis bullosa acquisita.

Abstract:

:Epidermolysis bullosa acquisita (EBA) is an autoimmune-mediated subepidermal bullous disease in which the target of the autoantibodies is type VII collagen, a major component of anchoring fibrils. The purpose of this study was to evaluate the complement-fixing abilities and IgG subclass distribution of autoantibodies in EBA, and to also attempt to investigate the relation between inflammation, complement fixation and IgG subclass distribution in EBA patients. Only 2 sera of 18 patients (11%) showed weak complement-fixing abilities. IgG1 and IgG4 were the most frequently and intensely stained IgG subclasses in EBA sera. We could not find any relationship between the clinico-pathologic types, complement-fixing abilities and IgG subclasses in EBA. These results suggested that complement activation may not be a key factor of bulla formation in EBA.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Cho HJ,Lee IJ,Kim SC

doi

10.3349/ymj.1998.39.4.339

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

339-44

issue

4

eissn

0513-5796

issn

1976-2437

journal_volume

39

pub_type

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