Abstract:
:Epidermolysis bullosa acquisita (EBA) is an autoimmune-mediated subepidermal bullous disease in which the target of the autoantibodies is type VII collagen, a major component of anchoring fibrils. The purpose of this study was to evaluate the complement-fixing abilities and IgG subclass distribution of autoantibodies in EBA, and to also attempt to investigate the relation between inflammation, complement fixation and IgG subclass distribution in EBA patients. Only 2 sera of 18 patients (11%) showed weak complement-fixing abilities. IgG1 and IgG4 were the most frequently and intensely stained IgG subclasses in EBA sera. We could not find any relationship between the clinico-pathologic types, complement-fixing abilities and IgG subclasses in EBA. These results suggested that complement activation may not be a key factor of bulla formation in EBA.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Cho HJ,Lee IJ,Kim SCdoi
10.3349/ymj.1998.39.4.339subject
Has Abstractpub_date
1998-08-01 00:00:00pages
339-44issue
4eissn
0513-5796issn
1976-2437journal_volume
39pub_type
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1990.31.3.205
更新日期:1990-09-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2000.41.3.354
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1991.32.3.215
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2008-02-29 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章,随机对照试验
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更新日期:2014-11-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 临床试验,杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1994.35.4.453
更新日期:1994-12-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2006.47.3.393
更新日期:2006-06-30 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2016.57.1.187
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
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pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2008-08-30 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2008-10-31 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
doi:10.3349/ymj.2004.45.6.998
更新日期:2004-12-31 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1996.37.4.290
更新日期:1996-08-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章,随机对照试验
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更新日期:2018-07-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
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更新日期:2007-02-28 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00