Abstract:
:The use of nickel-containing alloys in dentistry has been questioned because of the biological liabilities of nickel and the release of nickel ions from dental appliances into the oral cavity. The uptake of nickel by cells in the oral tissues is a critical factor in assessing the biological liabilities of nickel. Nickel uptake by macrophages may be particularly important because of the central role of macrophages in the inflammatory process and the known role of the macrophage in orchestrating the response to biomaterials. The aims of the current study were to assess the reversibility of the uptake of nickel from human macrophages and determine the portion of the nickel which reaches the nuclei as a function of time. Cellular nickel content was measured by means of atomic absorption spectrometry. Nuclear nickel content was assessed after fractionating cells. The results showed that nickel was rapidly taken up by macrophages and that the nickel accumulated in the nucleus in as little as 8 h. After 48 h, over 60% of the cellular nickel was in the nucleus. Once taken up, the nickel was lost at a lower rate. The rate of loss decreased as the initial exposure time to the nickel increased. Thus, the results indicated that macrophages may accumulate nickel if the time between exposures is insufficient to reverse the uptake. Further studies are necessary to correlate the retention of nickel with impaired function of macrophages and to further define the biological risks of using nickel in dental alloys.
journal_name
J Oral Rehabiljournal_title
Journal of oral rehabilitationauthors
Edwards DL,Wataha JC,Hanks CTdoi
10.1046/j.1365-2842.1998.00197.xsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
2-7issue
1eissn
0305-182Xissn
1365-2842journal_volume
25pub_type
杂志文章abstract::Physiological tooth movements during mandibular excursions with and without occlusion have been considered. Using electronic and pantographic techniques, anterior guidance and tooth movements during simulated mastication (without a bolus) were investigated. Investigations in the absence of occlusion showed that elasti...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.1981.tb00523.x
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journal_title:Journal of oral rehabilitation
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journal_title:Journal of oral rehabilitation
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abstract::A mechanical model (link quadrilateral bell crank) is used to demonstrate the equilibrium of normal force vectors transmitted to the masticatory system and maxillary occlusal biteplane splints with different designs. Occlusal contacts were imposed on the proposed models under the action of a masticatory force vector w...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.1995.tb00090.x
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pub_type: 杂志文章
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journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.1995.tb00211.x
更新日期:1995-01-01 00:00:00
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journal_title:Journal of oral rehabilitation
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更新日期:2009-12-01 00:00:00
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更新日期:1997-12-01 00:00:00
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journal_title:Journal of oral rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1111/joor.12505
更新日期:2017-06-01 00:00:00
abstract::It is considered that the information of chewed food, such as size and texture, is important for smooth mastication. In this study, we analysed aspects of the control of occlusal force, by experimentally reproducing situations in which the hardness of food changed unpredictably during mastication, using a device that ...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2007.01746.x
更新日期:2008-01-01 00:00:00
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journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/joor.12403
更新日期:2016-08-01 00:00:00
abstract::Full-arch immediate loading implant rehabilitations provide patients with compromised dentition an effective treatment to improve their aesthetic and function. Aim of this prospective cohort study was to investigate the correlation between masticatory ability and gastric emptying rates among these patients. Ten subjec...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/joor.12301
更新日期:2015-09-01 00:00:00
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更新日期:2009-10-01 00:00:00
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journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.1365-2842.2003.01039.x
更新日期:2003-08-01 00:00:00
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journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2005.01455.x
更新日期:2005-07-01 00:00:00
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journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.1365-2842.2002.00965.x
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journal_title:Journal of oral rehabilitation
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journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
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abstract::Nocturnal bite force during sleep associated bruxism was measured in 10 subjects. Hard acrylic dental appliances were fabricated for the upper and lower dentitions of each subject. Miniature strain-gauge transducers were mounted to the upper dental appliance at the right and left first molar regions. In addition, thin...
journal_title:Journal of oral rehabilitation
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journal_title:Journal of oral rehabilitation
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journal_title:Journal of oral rehabilitation
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doi:10.1111/j.1365-2842.1980.tb00433.x
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abstract::Experimental loss of occlusal support caused by the extraction or grinding of molar teeth has been reported to foment the impairment of learning and memory in laboratory animals. The purpose of this study was to examine the effect of occlusal reconstruction after long-term loss of molars on spatial memory by using 8-a...
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