Abstract:
:In order to determine the absolute bioavailability, both oral and intravenous administrations of a drug are often used. Recently a new method has been proposed to determine absolute bioavailability in the absence of intravenous dose. Following a single oral dose, this method requires oral and renal clearance data from normal subjects and renal failure patients. The bioavailability is calculated from a plot of oral against renal clearance following an oral dose, where the inverse of the slope is equal to absolute bioavailability. This study examines the prediction of absolute bioavailability from the proposed method for eight drugs which have a wide range of oral and renal clearance. From this study, it appears that the proposed method may not be reliable for the prediction of absolute bioavailability and further investigation is needed to test the validity of this method.
journal_name
Biopharm Drug Disposjournal_title
Biopharmaceutics & drug dispositionauthors
Mahmood Idoi
10.1002/(sici)1099-081x(199708)18:6<465::aid-bdd41subject
Has Abstractpub_date
1997-08-01 00:00:00pages
465-73issue
6eissn
0142-2782issn
1099-081Xpii
10.1002/(SICI)1099-081X(199708)18:6<465::AID-BDD41journal_volume
18pub_type
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